scholarly journals Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3731 ◽  
Author(s):  
Aleksandra Zielińska ◽  
Filipa Carreiró ◽  
Ana M. Oliveira ◽  
Andreia Neves ◽  
Bárbara Pires ◽  
...  
Keyword(s):  
Active Compound ◽  
Targeted Delivery ◽  
Size Range ◽  
Polymeric Nanoparticles ◽  
In Vitro Release ◽  
Morphological Structure ◽  
Active Compounds ◽  
Vitro Release

Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

scholarly journals Optimized Preparation of Levofloxacin Loaded Polymeric Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 57 ◽  
Author(s):  
Manuel López-López ◽  
Angela Fernández-Delgado ◽  
María Moyá ◽  
Daniel Blanco-Arévalo ◽  
Cecilio Carrera ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Polymeric Nanoparticles ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Antimicrobial Activities ◽  
Plga Nanoparticles ◽  
Time Period ◽  
Vitro Release

In this work, poly(lactic-co-glycolic acid) (PLGA) and chitosan (CS) nanoparticles were synthesized with the purpose of encapsulating levofloxacin (LEV). A thorough study has been carried out in order to optimize the preparation of LEV-loaded polymeric nanoparticles (NPs) suitable for parenteral administration. Changes in the preparation method, in the organic solvent nature, in the pH of the aqueous phase, or in the temperature were investigated. To the authors´ knowledge, a systematic study in order to improve the LEV nanocarrier characteristics and the yield of drug encapsulation has not been carried out to date. The physicochemical characterization of the NPs, their encapsulation efficiency (EE), and the in vitro release of LEV revealed that the best formulation was the emulsion-solvent evaporation method using dichloromethane as organic solvent, which renders suitable LEV loaded PLGA NPs. The morphology of these NPs was investigated using TEM. Their antimicrobial activities against several microorganisms were determined in vitro measuring the minimum inhibitory concentration (MIC). The results show that the use of these loaded LEV PLGA nanoparticles has the advantage of the slow release of the antibiotic, which would permit an increase in the time period between administrations as well as to decrease the side effects of the drug.

Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles

2002 ◽  
Vol 234 (1-2) ◽  
pp. 195-203 ◽  
Author(s):  
Hak Soo Choi ◽  
Sun-Ah Seo ◽  
Gilson Khang ◽  
John M. Rhee ◽  
Hai Bang Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release ◽  
Release Profiles

Synthesis, characterization of dextran hydrogels and their in vitro release of gentamycin sulphate

2015 ◽  
Vol 13 (3) ◽  
pp. 0-0 ◽  
Author(s):  
Rui Guo ◽  
Peizhe Chen ◽  
Yunfei Mo ◽  
Yong Lan ◽  
Wei Xue ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Vitro Release

scholarly journals Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 548 ◽  
Author(s):  
Naveed Ahmad ◽  
Danial Tayyeb ◽  
Imran Ali ◽  
Nabil K. Alruwaili ◽  
Waqas Ahmad ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Transmission Rate ◽  
In Vitro Release ◽  
Antibacterial Activities ◽  
Cell Viability Assay ◽  
Viability Assay ◽  
Psyllium Husk ◽  
Vitro Release

Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

scholarly journals Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: in vitro release and cytotoxicity studies

2013 ◽  
Vol 23 (1) ◽  
pp. 153-159 ◽  
Author(s):  
Luciano Aparecido Stecanella ◽  
Stephânia Fleury Taveira ◽  
Ricardo Neves Marreto ◽  
Marize C. Valadares ◽  
Marcelo de Sousa Vieira ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Cytotoxicity Studies ◽  
Vitro Release

Formulation and characterization of curcumin-loaded microemulsions: evaluation of antioxidant stability and in vitro release

2021 ◽  
pp. 116881
Author(s):  
Aibibai Amuti ◽  
Xue Wang ◽  
Mingyang Zan ◽  
Shaojun Lv ◽  
Zhanzhong Wang
Keyword(s):  
In Vitro Release ◽  
Vitro Release

In vitro release of somatostatin from cerebral cortical slices: characterization of electrically evoked release

1988 ◽  
Vol 447 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Giambattista Bonanno ◽  
Maurizio Raiteri ◽  
Piers C. Emson
Keyword(s):  
In Vitro Release ◽  
Vitro Release ◽  
Cortical Slices
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