scholarly journals Reaction of Aldoximes with Sodium Chloride and Oxone under Ball-Milling Conditions

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3719
Author(s):  
Kuan Chen ◽  
Chuang Niu ◽  
Guan-Wu Wang
Keyword(s):  
Reaction Time ◽  
Sodium Chloride ◽  
Liquid Phase ◽  
Ball Milling ◽  
Reaction Pathway ◽  
Solvent Free ◽  
Mechanochemical Reaction ◽  
Reaction Efficiency ◽  
Mild Conditions ◽  
Mechanical Ball Milling

The solvent-free mechanochemical reaction has aroused increasing interest among scientists. Mechanical ball-milling can implement reactions under mild conditions, shorten the reaction time, and improve the reaction efficiency. Particularly, the most attractive characteristic of mechanochemistry is that it can alter the reaction pathway. However, few such examples have been reported so far. In this paper, we report the reaction of aldoximes with NaCl and Oxone under ball-milling conditions to afford N-acyloxyimidoyl chlorides, which are different from those of the liquid-phase counterpart.

Solvent-free iodine-promoted synthesis of 3,2′-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions

2017 ◽  
Vol 53 (92) ◽  
pp. 12477-12480 ◽  
Author(s):  
Hui Xu ◽  
Hong-Wei Liu ◽  
Hao-Sheng Lin ◽  
Guan-Wu Wang
Keyword(s):  
Ball Milling ◽  
Solvent Free ◽  
Mechanochemical Reaction ◽  
Free Iodine

A solvent-free mechanochemical reaction of alkylidene oxindoles with enamino esters via an iodine-promoted tandem Michael/cyclization sequence has been developed to provide a variety of spirocyclic oxindoles in moderate to good yields with excellent diastereoselectivities.

Rapid and efficient solvent-free synthesis of cyclophanes based on bipyridinium under mechanical ball milling

RSC Advances ◽  
2013 ◽  
Vol 3 (3) ◽  
pp. 691-694 ◽  
Author(s):  
Hai-Tao Xi ◽  
Ting Zhao ◽  
Xiao-Qiang Sun ◽  
Chun-Bao Miao ◽  
Ting Zong ◽  
...  
Keyword(s):  
Ball Milling ◽  
Solvent Free ◽  
Solvent Free Synthesis ◽  
Mechanical Ball Milling

scholarly journals An Efficient One-Pot Synthesis of 1, 5-Benzodiazepine Derivatives Catalyzed by TBAB under Mild Conditions

2012 ◽  
Vol 9 (1) ◽  
pp. 407-414 ◽  
Author(s):  
Mohammad A. Baseer ◽  
Asgar Jafar Khan
Keyword(s):  
Reaction Time ◽  
Solvent Free ◽  
Ammonium Bromide ◽  
One Pot ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Excellent Yield ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Benzodiazepine Derivatives

2,3-Dihydro-1H-1,5-benzodiazepines were synthesized by reaction ofo-phenylenediamine with ketones (acyclic / cyclic) under solvent free conditions in the presence of tetra butyl ammonium bromide (TBAB) in short reaction time with excellent yield.

A highly effective and mild protocol for the production of 1-thioamidoalkyl-2-naphthols using 1,3-disulfonic acid imidazolium trifluoroacetate as a dual-functional catalyst

2018 ◽  
Vol 73 (5) ◽  
pp. 289-293 ◽  
Author(s):  
Mostafa Karami ◽  
Abdolkarim Zare
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
Reaction Times ◽  
Solvent Free ◽  
Disulfonic Acid ◽  
One Pot ◽  
Mild Conditions ◽  
Dual Functional ◽  
Highly Effective ◽  
High Yields

AbstractA solvent-free protocol for the production of 1-thioamidoalkyl-2-naphthols via a one-pot multi-component reaction of arylaldehydes with 2-naphthol and thioacetamide using the ionic liquid 1,3-disulfonic acid imidazolium trifluoroacetate ([Dsim][TFA]) is described. Furthermore, a plausible and attractive mechanism based on the dual functionality of the catalyst is proposed. Because of the dual functionality of [Dsim][TFA] (possessing acidic and basic sites), it is found to be generally highly effective, affording the products in high yields and short reaction times under mild conditions. We claim that this is one of the best protocols for the synthesis of 1-thioamidoalkyl-2-naphthols (in terms of yield, temperature, conditions, and/or the reaction time).

Solvent-free reactions of alkynes in ball mills: It is definitely more than mixing

2011 ◽  
Vol 83 (7) ◽  
pp. 1343-1349 ◽  
Author(s):  
Achim Stolle ◽  
Bernd Ondruschka
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Ball Milling ◽  
Cross Coupling ◽  
Solvent Free ◽  
Terminal Alkynes ◽  
Turnover Frequency ◽  
Ball Mills ◽  
Turnover Number ◽  
Solvent Free Reaction

This contribution presents two solvent-free reactions of terminal alkynes in ball mills: Pd-catalyzed Sonogashira cross-coupling and Cu-catalyzed homo-coupling (Glaser reaction). The results are compared to other solvent-free reaction protocols, which have been published up to date for those types of reactions. Reactions are assessed on the basis of reaction variables like type of catalyst and base or reaction time. Furthermore, performance-based parameters (yield, selectivity, turnover number, TON, and turnover frequency, TOF) are considered and evaluated. Findings from ball-milling experiments indicate that those processes are comparable to the energy entry by microwave irradiation with respect to reaction time and TOF.

Mechanical Ball Milling and Liquid Phase Sintering of Steel-Bonded Cemented Carbide Machining Crumbs

2013 ◽  
Vol 765-767 ◽  
pp. 210-212
Author(s):  
Jian Ye ◽  
Wei Gao ◽  
Wen Ke Li ◽  
Zhao Qiang Zeng
Keyword(s):  
Wear Resistance ◽  
Liquid Phase ◽  
Ball Milling ◽  
Liquid Phase Sintering ◽  
Experimental Results ◽  
Cemented Carbide ◽  
Carbide Alloy ◽  
Conventional Steel ◽  
Mechanical Ball Milling

The technology is introduced about mechanical ball milling and liquid phase sintering of machining crumbs of steel based carbide alloy in this article. The materials obtained from machining crumbs of steel-bonded cemented carbide are qualified compared with the conventional steel-bonded cemented carbide materials in the aspects of hardness, wear resistance by using the technology and the process is reasonable and practicable, according to experimental results. It can be extremely important when considering the recycling and make full use of tungsten resources.

Solvent-Free and Liquid-Phase Iodination of Thiophene Derivatives with Potassium Dichloroiodate Monohydrate

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 1140-1146
Author(s):  
Grigoriy Sereda ◽  
Akash Mamon Sarkar ◽  
Anwar Hussain ◽  
Nikolai Zefirov
Keyword(s):  
Liquid Phase ◽  
Small Extent ◽  
Solvent Free ◽  
Mechanochemical Reaction ◽  
Benzene Derivatives ◽  
Solvent Free Conditions ◽  
Solid Substrates ◽  
Thiophene Derivatives

Iodination of a series of benzene and thiophene derivatives by potassium dichloroiodate monohydrate was studied with and without a solvent. The liquid substrates tend to be more reactive in water while the solid substrates afford better yields in dichloromethane or under the solvent-free conditions. The 2-substituted thiophenes show good to excellent yields whereas the yield for 3-substituted and 3,4- or 2,4-disubstituted thiophenes and benzene derivatives are significantly lower. The mechanochemical reaction of 5-carbaldehyde-2,2′-bithiophene shows excellent yields, while 2,2′-bithiophene gives practical yields only in dichloromethane. In the case of thiophene and N-acetyl-p-toluidine, electrophilic iodination is accompanied by a small extent of chlorination.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Sign in / Sign up

Export Citation Format

Share Document