scholarly journals Advances in Saponin Diversity of Panax ginseng

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3452
Author(s):  
Xiangmin Piao ◽  
Hao Zhang ◽  
Jong Pyo Kang ◽  
Dong Uk Yang ◽  
Yali Li ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Panax Ginseng ◽  
Chemical Structure ◽  
Side Chain ◽  
Pharmacological Effects ◽  
Bioactive Constituents ◽  
Flower Bud ◽  
Multiple Dimensions ◽  
Ginseng Plant ◽  
Different Parts

Ginsenosides are the major bioactive constituents of Panax ginseng, which have pharmacological effects. Although there are several reviews in regards to ginsenosides, new ginsenosides have been detected continually in recent years. This review updates the ginsenoside list from P. ginseng to 170 by the end of 2019, and aims to highlight the diversity of ginsenosides in multiple dimensions, including chemical structure, tissue spatial distribution, time, and isomeride. Protopanaxadiol, protopanaxatriol and C17 side-chain varied (C17SCV) manners are the major types of ginsenosides, and the constitute of ginsenosides varied significantly among different parts. Only 16 ginsenosides commonly exist in all parts of a ginseng plant. Protopanaxadiol-type ginsenoside is dominant in root, rhizome, leaf, stem, and fruit, whereas malonyl- and C17SCV-type ginsenosides occupy a greater proportion in the flower and flower bud compared with other parts. In respects of isomeride, there are 69 molecular formulas corresponding to 170 ginsenosides, and the median of isomers is 2. This is the first review on diversity of ginsenosides, providing information for reasonable utilization of whole ginseng plant, and the perspective on studying the physiological functions of ginsenoside for the ginseng plant itself is also proposed.

scholarly journals Discovering the Major Antitussive, Expectorant, and Anti-Inflammatory Bioactive Constituents in Tussilago farfara L. Based on the Spectrum–Effect Relationship Combined with Chemometrics

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 620 ◽  
Author(s):  
Liu Yang ◽  
Hai Jiang ◽  
Song Wang ◽  
Ajiao Hou ◽  
Wenjing Man ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Pharmacological Effects ◽  
Least Squares Regression ◽  
Bioactive Constituents ◽  
Flower Bud ◽  
Active Compounds ◽  
Effect Relationship ◽  
Tussilago Farfara ◽  
Anti Inflammatory ◽  
Spectrum Effect

Farfarae Flos (FF) is the dried flower bud of Tussilago farfara L, which has antitussive, expectorant, and anti-inflammatory effects. However, little research on the main active composition of FF has been reported. The purpose of this study is to find the main active compounds responsible for the three pharmacological effects (i.e., antitussive, expectorant, and anti-inflammatory effects) of Farfarae Flos, based on the spectrum–effect relationship combined with chemometrics. First, this study uses the UPLC-QDA method to establish the chromatography fingerprint of Farfarae Flos, which is combined with chemometrics to analyze 18 batches of samples. Then, we study the antitussive, expectorant, and anti-inflammatory effects of Farfarae Flos. Finally, the spectrum–effect relationship between the fingerprint and the three pharmacological effects are studied by grey correlation analysis and partial least squares regression. The results show that four, four, and three main active constituents were found for the antitussive, expectorant, and anti-inflammatory pharmacological effects, respectively. In conclusion, we found the main active compounds corresponding to the main pharmacodynamic effects of Farfarae Flos. To our knowledge, this is the first time that spectrum–effect relationships in FF have been established using both raw and processed samples, which provides an experimental basis for further studies on the pharmacodynamic material basis of Farfarae Flos, as well as providing reference for the comprehensive evaluation of Farfarae Flos quality and the development of substitute resources.

Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)

2019 ◽  
Vol 70 (7) ◽  
pp. 2534-2537
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Antonia Poiata ◽  
Mihai Nichifor ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Ethylene Diamine ◽  
Chemical Characteristics ◽  
Gram Negative Bacteria ◽  
Pharmacological Effects ◽  
Physico Chemical ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

scholarly journals Effects of Amino Acid Side-Chain Length and Chemical Structure on Anionic Polyglutamic and Polyaspartic Acid Cellulose-Based Polyelectrolyte Brushes

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1789
Author(s):  
Dmitry Tolmachev ◽  
George Mamistvalov ◽  
Natalia Lukasheva ◽  
Sergey Larin ◽  
Mikko Karttunen
Keyword(s):  
Glutamic Acid ◽  
Chain Length ◽  
Chemical Structure ◽  
Side Chain ◽  
Side Chains ◽  
Side Chain Length ◽  
Polyelectrolyte Brushes ◽  
Grafting Density ◽  
The Difference ◽  
Cellulose Surface

We used atomistic molecular dynamics (MD) simulations to study polyelectrolyte brushes based on anionic α,L-glutamic acid and α,L-aspartic acid grafted on cellulose in the presence of divalent CaCl2 salt at different concentrations. The motivation is to search for ways to control properties such as sorption capacity and the structural response of the brush to multivalent salts. For this detailed understanding of the role of side-chain length, the chemical structure and their interplay are required. It was found that in the case of glutamic acid oligomers, the longer side chains facilitate attractive interactions with the cellulose surface, which forces the grafted chains to lie down on the surface. The additional methylene group in the side chain enables side-chain rotation, enhancing this effect. On the other hand, the shorter and more restricted side chains of aspartic acid oligomers prevent attractive interactions to a large degree and push the grafted chains away from the surface. The difference in side-chain length also leads to differences in other properties of the brush in divalent salt solutions. At a low grafting density, the longer side chains of glutamic acid allow the adsorbed cations to be spatially distributed inside the brush resulting in a charge inversion. With an increase in grafting density, the difference in the total charge of the aspartic and glutamine brushes disappears, but new structural features appear. The longer sides allow for ion bridging between the grafted chains and the cellulose surface without a significant change in main-chain conformation. This leads to the brush structure being less sensitive to changes in salt concentration.

scholarly journals A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix

2020 ◽  
Vol 2020 ◽  
pp. 1-28
Author(s):  
Liu Yang ◽  
Ajiao Hou ◽  
Song Wang ◽  
Jiaxu Zhang ◽  
Wenjing Man ◽  
...  
Keyword(s):  
Quality Control ◽  
Mechanism Of Action ◽  
Analytical Methods ◽  
Lumbar Disc ◽  
Pharmacological Study ◽  
Relevant Information ◽  
Chemical Components ◽  
Pharmacological Effects ◽  
Bioactive Constituents ◽  
Traditional Use

Angelicae Pubescentis Radix (AP), as a traditional Chinese medicine (TCM), has been used for thousands of years in China. In this paper, the botany, traditional use, phytochemistry, analytical methods, quality control, pharmacological effects, and toxicity of AP were reviewed. It can provide a reference for the further research and lay a foundation for the rational clinical application of AP. The relevant information on AP was collected from scientific databases (such as Baidu Scholar, CNKI, Google Scholar, PubMed, Science Direct, Web of Science, and SciFinder Scholar), Chinese herbal classics, Chinese Pharmacopoeia, PhD and MSc dissertations, and so on. The components which have been isolated and identified in AP include coumarins, volatile oils, organic acids, terpenes, polysaccharides, flavonoids, sterols, and trace elements. Most of them were analyzed by HPLC and GC. A pharmacological study shows that the AP has extensive pharmacological effects, including anti-inflammatory, antirheumatism, sedative and hypnotic, neuroprotection, antioxidation, antitumor, and allergy, and it is widely used in the treatment of the rheumatoid arthritis, knee osteoarthritis, lumbar disc, ankylosing spondylitis, headaches, stroke hemiplegia, Alzheimer’s, and arrhythmia. AP is a valuable natural medicinal plant. So far, significant advances have been made in phytochemistry and pharmacology. Some traditional uses have been demonstrated by modern pharmacology. However, the chemical components and pharmacological effects of AP are complex and varied, and there are different standards for the evaluation of its quality and efficacy. The mechanism of action, the structure-activity relationship among the components, and the potential synergistic and antagonistic effects remain to be studied. At the same time, there are few studies on the specific compounds related to its pharmacodynamics. In order to better develop and utilize AP, we should establish a more reasonable, reliable, and accurate quality control standard and focus on the study of bioactive constituents and the demonstration of their mechanism of action.

Ginsenosides from the Leaves and Flower Buds of Panax ginseng and their Pharmacological Effects

2012 ◽  
Vol 8 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Nguyen Huu Tung ◽  
Gyu Yong Song ◽  
Sun-Hee Woo ◽  
Jin Won Hyun ◽  
Young Sang Koh ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Pharmacological Effects ◽  
Flower Buds

3D simulations of warm and hot Jupiter atmospheres: the role of 3D mixing in shaping CH4-to-CO conversion pathways

2021 ◽  
Author(s):  
Maria Zamyatina ◽  
Eric Hebrard ◽  
Nathan Mayne ◽  
Benjamin Drummond
Keyword(s):  
Chemical Structure ◽  
Three Dimensional ◽  
Chemical Species ◽  
Radiation Chemistry ◽  
3D Simulations ◽  
Horizontal Advection ◽  
Co Conversion ◽  
Area Of Influence ◽  
Different Parts

<p>We present results from a set of cloud-free simulations of exoplanet atmospheres using a coupled three-dimensional (3D) hydrodynamics-radiation-chemistry model. We report in particular our investigation of the thermodynamic and chemical structure of the atmospheres of HAT-P-11b and WASP-17b and their comparison with the results for the atmospheres of HD 189733b and HD 209458b presented in Drummond et al. (2020). We found that the abundances of chemical species from simulations with interactive chemistry depart from their respective abundances computed at local chemical equilibrium, especially at higher latitudes. To understand this departure, we analysed the CH<sub>4</sub>-to-CO conversion pathways within the Venot et al. (2019) reduced chemical network used in our model using a chemical network analysis. We found that at steady state nine CH<sub>4</sub>-to-CO conversion pathways manifest in our 3D simulations with interactive chemistry, with different pathways dominating different parts of the atmosphere and their area of influence being determined by the vertical and horizontal advection and shifting between planets.</p>

scholarly journals Synthesis of Imidazol-2-yl Amino Acids by Using Cells from Alkane-Oxidizing Bacteria

2003 ◽  
Vol 69 (3) ◽  
pp. 1670-1679 ◽  
Author(s):  
Annett Mikolasch ◽  
Elke Hammer ◽  
Frieder Schauer
Keyword(s):  
Amino Acids ◽  
Chemical Structure ◽  
Rhodococcus Erythropolis ◽  
Nocardia Asteroides ◽  
Side Chain ◽  
Butanoic Acid ◽  
Transformation Pathway ◽  
Nuclear Magnetic Resonance Spectrometry ◽  
Magnetic Resonance Spectrometry ◽  
High Yields

ABSTRACT Sixty-one strains of alkane-oxidizing bacteria were tested for their ability to oxidize N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide to imidazol-2-yl amino acids applicable for pharmaceutical purposes. After growth with n-alkane, 15 strains formed different imidazol-2-yl amino acids identified by chemical structure analysis (mass and nuclear magnetic resonance spectrometry). High yields of imidazol-2-yl amino acids were produced by the strains Gordonia rubropertincta SBUG 105, Gordonia terrae SBUG 253, Nocardia asteroides SBUG 175, Rhodococcus erythropolis SBUG 251, and Rhodococcus erythropolis SBUG 254. Biotransformation occurred via oxidation of the alkyl side chain and produced 1-acetylamino-4-phenylimidazol-2-yl-6-aminohexanoic acid and the butanoic acid derivative. In addition, the acetylamino group of these products and of the substrate was transformed to an amino group. The product pattern as well as the transformation pathway of N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide differed in the various strains used.

scholarly journals Bioactive Compounds from Brassicaceae: a Beneficial Contribution in our Everyday Diet

2011 ◽  
Vol 68 (2) ◽  
Author(s):  
Renato IORI ◽  
Gina R. DE NICOLA ◽  
Manuela BAGATTA ◽  
Eleonora PAGNOTTA
Keyword(s):  
Secondary Metabolites ◽  
Dietary Intake ◽  
Bioactive Compounds ◽  
Chemical Structure ◽  
Side Chain ◽  
Variable Part ◽  
Naturally Occurring ◽  
Interesting Class

Dietary intake of Brassicaceae (Crucifers) provides not only nutrients, but also a highly interesting class of secondary metabolites beneficial to health, known as glucosinolates (GLs). These compounds possess a -D-glucopyranosyl unit connected to a O-sulfated anomeric Z-thiohydroximate function, and a side chain R which is the only variable part of the chemical structure. Up to now, more than 120 naturally-occurring GLs have been carachterized

Global Patterns of Climate-resilient Agriculture: A Review of Studies and Imperatives for Empirical Research in India

2020 ◽  
Vol 25 (2) ◽  
pp. 169-192
Author(s):  
P. K. Viswanathan ◽  
K. Kavya ◽  
Chandra Sekhar Bahinipati
Keyword(s):  
Climate Change ◽  
Empirical Research ◽  
Cropping Systems ◽  
Climate Change Impacts ◽  
Agriculture Sector ◽  
Indian Context ◽  
Multiple Dimensions ◽  
The World ◽  
Emerging Patterns ◽  
Different Parts

Globally, climate change impacts are manifold, severely affecting the agriculture sector. Climate-resilient agriculture (CRA) is viewed as a panacea for overcoming the adverse effects of climate change on agriculture. This article critically reviews the literature on CRA to delineate the emerging patterns of climate-resilient agriculture. It explores multiple dimensions of CRA as related to practices, technologies, policies, innovations and interventions across different parts of the world. In the end, a schematic approach towards undertaking empirical research on CRA in the Indian context is presented. The review finds that, globally, CRA practices mainly include systematic strategies for management of critical inputs, namely, land and water, cropping systems and livelihood management. It emerges that innovations and institutions have a crucial role in accelerating the rate of adoption of CRA practices. The article highlights the need for undertaking more empirical research to get a deeper understanding of the emerging patterns of CRA in the Indian context.

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