scholarly journals Discovering the Major Antitussive, Expectorant, and Anti-Inflammatory Bioactive Constituents in Tussilago farfara L. Based on the Spectrum–Effect Relationship Combined with Chemometrics

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 620 ◽  
Author(s):  
Liu Yang ◽  
Hai Jiang ◽  
Song Wang ◽  
Ajiao Hou ◽  
Wenjing Man ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Pharmacological Effects ◽  
Least Squares Regression ◽  
Bioactive Constituents ◽  
Flower Bud ◽  
Active Compounds ◽  
Effect Relationship ◽  
Tussilago Farfara ◽  
Anti Inflammatory ◽  
Spectrum Effect

Farfarae Flos (FF) is the dried flower bud of Tussilago farfara L, which has antitussive, expectorant, and anti-inflammatory effects. However, little research on the main active composition of FF has been reported. The purpose of this study is to find the main active compounds responsible for the three pharmacological effects (i.e., antitussive, expectorant, and anti-inflammatory effects) of Farfarae Flos, based on the spectrum–effect relationship combined with chemometrics. First, this study uses the UPLC-QDA method to establish the chromatography fingerprint of Farfarae Flos, which is combined with chemometrics to analyze 18 batches of samples. Then, we study the antitussive, expectorant, and anti-inflammatory effects of Farfarae Flos. Finally, the spectrum–effect relationship between the fingerprint and the three pharmacological effects are studied by grey correlation analysis and partial least squares regression. The results show that four, four, and three main active constituents were found for the antitussive, expectorant, and anti-inflammatory pharmacological effects, respectively. In conclusion, we found the main active compounds corresponding to the main pharmacodynamic effects of Farfarae Flos. To our knowledge, this is the first time that spectrum–effect relationships in FF have been established using both raw and processed samples, which provides an experimental basis for further studies on the pharmacodynamic material basis of Farfarae Flos, as well as providing reference for the comprehensive evaluation of Farfarae Flos quality and the development of substitute resources.

An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review

2020 ◽  
Vol 20 (11) ◽  
pp. 988-1000 ◽  
Author(s):  
Bellamkonda Bosebabu ◽  
Sri Pragnya Cheruku ◽  
Mallikarjuna Rao Chamallamudi ◽  
Madhavan Nampoothiri ◽  
Rekha R. Shenoy ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Biological Effects ◽  
Hepatoprotective Activity ◽  
In Vivo Studies ◽  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Bioactive Constituents ◽  
Anti Inflammatory

Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non‐toxic chemical that mediates anti‐inflammatory effects by down‐regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.

Screening of analgesic and anti-inflammatory active component in Fructus Alpiniae zerumbet based on spectrum-effect relationship and GC-MS

2017 ◽  
Vol 32 (3) ◽  
pp. e4112 ◽  
Author(s):  
Rui-Yao Xiao ◽  
Ling-Jing Wu ◽  
Xiao-Xiao Hong ◽  
Ling Tao ◽  
Peng Luo ◽  
...  
Keyword(s):  
Active Component ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

Identification of anti-inflammatory components in Sinomenii Caulis based on spectrum-effect relationship and chemometric methods

2019 ◽  
Vol 167 ◽  
pp. 38-48 ◽  
Author(s):  
Lan-Jin Wang ◽  
Zheng-Meng Jiang ◽  
Ping-Ting Xiao ◽  
Jian-Bo Sun ◽  
Zhi-Ming Bi ◽  
...  
Keyword(s):  
Chemometric Methods ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

scholarly journals Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wenxin Xia ◽  
Qiansong Liu ◽  
Hao Zhou ◽  
Shiyao Hua ◽  
Lin Dong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Performance ◽  
Gray Relational Analysis ◽  
Least Squares Regression ◽  
Effect Relationship ◽  
Long Time ◽  
Pharmacological Substance ◽  
New Research ◽  
Spectrum Effect

Licorice is a traditional Chinese medicine that has been used for a long time in China and still in great use today. The effect of licorice on tonifying spleen and invigorating qi has been proved for thousands of years, but the material basis of its effect is not clear. In this paper, we established the fingerprints of 21 batches of licorice collected from different origins in China with High-Performance Liquid Chromatography (HPLC) to identify the common peaks. Its effect of tonifying spleen and invigorating qi was confirmed through a series of praxiology experiments. The spectrum-effect relationship between HPLC fingerprints and its effect of tonifying spleen and invigorating qi of licorice was examined by gray relational analysis and partial least squares regression analysis. Results showed that the effect of licorice on tonifying spleen and invigorating qi resulted from various compounds and peaks. X2–X6 is presumed to be the main pharmacological substance base. This research successfully identified the spectrum-effect relationship between HPLC fingerprints and the effect of licorice on tonifying spleen and invigorating qi. The research method based on the spectrum-effect relationship helps provide new research ideas and strategies for the study of the basis of the medicinal materials and quality control of traditional Chinese medicine.

scholarly journals Identification of anti-inflammatory components of raw and steamed Panax notoginseng root by analyses of spectrum-effect relationship

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 17950-17958 ◽  
Author(s):  
Zejun Zhang ◽  
Lijuan Chen ◽  
Xiuming Cui ◽  
Yiming Zhang ◽  
Yupiao Hu ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

The differentiated components related to the anti-inflammatory effects of raw and steamed Panax notoginseng were uncovered by the analysis of spectrum-effect relationship.

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