scholarly journals An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2501 ◽  
Author(s):  
Tarek S. Ibrahim ◽  
Israa A. Seliem ◽  
Siva S. Panda ◽  
Amany M. M. Al-Mahmoudy ◽  
Zakaria K. M. Abdel-Samii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Drug Conjugates ◽  
Cost Efficient ◽  
High Yields

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

scholarly journals A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Amulrao Borse ◽  
Mahesh Patil ◽  
Nilesh Patil ◽  
Rohan Shinde
Keyword(s):  
Reaction Time ◽  
Ambient Temperature ◽  
Room Temperature ◽  
Simple Procedure ◽  
Methanesulfonic Acid ◽  
Phosphorus Pentoxide ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton’s reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.

A clean, simple and efficient synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h] quinolin-2-yl]-(4-chlorophenyl)methanones

2017 ◽  
Vol 41 (7) ◽  
pp. 380-383
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Reaction Time ◽  
Green Chemistry ◽  
Aromatic Aldehyde ◽  
Efficient Method ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
High Yields

We report a green and efficient method for the synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2- h]quinolin-2-yl]-(4-chlorophenyl) methanones from the condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 8-hydroxyquinoline and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water at reflux conditions. This new protocol employing choline hydroxide, which is a green and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction time, high yields and does not involve any hazardous solvent. Therefore, this procedure can be classified as green chemistry.

scholarly journals Rapid Reduction of Alkenes and Alkynes over Pd Nanoparticles Supported on Sulfonated Porous Carbon

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Arash Shokrolahi ◽  
Abbas Zali ◽  
Kamal Ghani
Keyword(s):  
Reaction Time ◽  
Porous Carbon ◽  
Room Temperature ◽  
Heterogeneous Reaction ◽  
Low Cost ◽  
Pd Nanoparticles ◽  
Rapid Reduction ◽  
Short Reaction Time ◽  
Novel Method ◽  
High Yields

A novel method has been introduced for rapid reduction of alkenes and alkynes, which may be attractive for chemical industries. This method has some advantages such as simplicity and low cost of reactants. Pd supported on sulfonated porous carbon (SPC) was used as a new catalyst for reduction of alkenes and alkynes to the corresponding alkanes using sodium borohydride. The heterogeneous reaction was conducted in open air at room temperature to produce the desired saturated compounds in high yields (over 96%) and in short reaction time (15 minutes).

Synthesis of a series of novel 2,3-dihydrofuranonaphthoquinone derivatives

2017 ◽  
Vol 41 (8) ◽  
pp. 448-451 ◽  
Author(s):  
Maryam Salari ◽  
Mohammad H. Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Reaction Time ◽  
Green Chemistry ◽  
Organic Solvent ◽  
Aromatic Aldehyde ◽  
Efficient Synthesis ◽  
One Pot ◽  
Short Reaction Time ◽  
Highly Efficient ◽  
One Pot Condensation ◽  
High Yields

A green and highly efficient synthesis of 12 novel trans-2-(4-chlorobenzoyl)-3-aryl-2,3-dihydronaphtho[2,3- b]furan-4,9-diones has been achieved via a three-component, one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 2-hydroxy-1,4-naphthoquinone and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. The advantages of this method are a short reaction time, high yields and the avoidance of any hazardous organic solvent. Therefore, this procedure can be classified as green chemistry.

Rapid Cesium Fluoride Catalyzed Synthesis of 5-Aryloxy-1-phenyl-1H-tetrazoles via Nucleophilic Aromatic Substitution

2020 ◽  
Vol 17 ◽  
Author(s):  
Syed Muhammad Saad ◽  
Shahnaz Perveen ◽  
Itrat Fatima ◽  
Khalid Mohammed Khan
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Nucleophilic Aromatic Substitution ◽  
Synthetic Approach ◽  
Aromatic Substitution ◽  
Short Reaction Time ◽  
Cesium Fluoride ◽  
High Yields

Abstract: A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilc catalyst as well as an elec-trophilic catalyst afforded the desired products at room temperature in a short reaction time without purification in high yields. This simple but useful reaction may be a rapid and reliable strategy for the synthesis of tetrazolyl ethers

A Study on the Sulfonation of Aromatic Amines with Sulfuric Acid under Microwave Irradiation

2003 ◽  
Vol 2003 (8) ◽  
pp. 493-494 ◽  
Author(s):  
Hui-Zhang Li ◽  
Li-Wei Xiao ◽  
Hong-Ya Li ◽  
Kai-Fang Wang ◽  
Xu Li
Keyword(s):  
Sulfuric Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Aromatic Amines ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

The sulfonation of aromatic amines with high yields, simple operations and short reaction time has been studied under microwave irradiation in solvent-free conditions.

Convenient and Efficient Synthesis of Thiol Esters using Zinc Oxide as a Heterogeneous and Eco-Friendly Catalyst

2008 ◽  
Vol 61 (12) ◽  
pp. 1006 ◽  
Author(s):  
Babasaheb Pandurang Bandgar ◽  
Parmeshwar Eknath More ◽  
Vinod Tribhuvannathji Kamble ◽  
Sanjay Suresh Sawant
Keyword(s):  
Zinc Oxide ◽  
Reaction Time ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Catalytic Method ◽  
Reaction Conditions ◽  
Acyl Chlorides ◽  
Short Reaction Time ◽  
Thiol Esters ◽  
Solvent Free Conditions

A catalytic method was developed to synthesize thiol esters from the reaction of acyl chlorides and thiols using zinc oxide as a catalyst under solvent-free conditions at room temperature. Mild reaction conditions, short reaction time, excellent yields of products and recyclability of the catalyst are noteworthy features of this methodology.

Microwave-Assisted Anomeric Deacetylation of Ribofuranoses with Fe(III) Reagents

2013 ◽  
Vol 859 ◽  
pp. 337-340
Author(s):  
Qiang Wang ◽  
Guo Dong Liu ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Product Yield ◽  
Experimental Results ◽  
Heating Condition ◽  
Thermal Heating ◽  
Microwave Assisted ◽  
Acetyl Group ◽  
Cost Efficient ◽  
High Yields

Treatment of protected furanoses with FeCl3·6H2O in acetonitrile with microwave irradiation provides an efficient and mild protocol for regioselective removal of anomeric O-acetyl group. This method features cost efficient reagents, simple procedures, and high yields. The experimental results proved that microwave irradiation could notably shorten the reaction time and increase the product yield compared to the conventional thermal heating condition.

Molybdenum carbide as an efficient and durable catalyst for aqueous Knoevenagel condensation

2019 ◽  
Vol 43 (42) ◽  
pp. 16437-16440 ◽  
Author(s):  
Mina Tavakolian ◽  
Mohammad Mahdi Najafpour
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Molybdenum Carbide ◽  
Knoevenagel Condensation ◽  
Aqueous Media ◽  
Short Reaction Time ◽  
Efficient Performance ◽  
High Yields

Molybdenum carbide showed an efficient performance for the Knoevenagel condensation in aqueous media at room temperature, affording the corresponding products in high yields within a short reaction time.

Trimethylsilyl Chloride Catalyzed Highly Efficient Synthesis of Schiff Bases of Thiazole in Glycerol under Microwave Irradiation

2019 ◽  
Vol 4 (2) ◽  
pp. 109-112
Author(s):  
Mujahed Shaikh ◽  
Ashvini Sonone ◽  
Mazahar Farooqui ◽  
Ayesha Durrani
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Room Temperature ◽  
Environmentally Benign ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Acidic Catalyst ◽  
Excellent Yield ◽  
Work Up

A green and environmentally benign protocol is developed for the synthesis of Schiff bases of sulphur containing compound by irradiating thiazole and pyrazole aldehyde in glycerol under microwave irradiation at 70 ºC with trimethylsilyl chloride (TMSCl) as a catalyst. The method has advantages such as excellent yield, use of green solvent, easy work-up and most important the reaction completed within 2.5 min by using TMSCl catalyst. The TMSCl is an acidic catalyst, which enhances the yield of product, reaction time (with microwave, with reflux at 75 ºC and with stirring at room temperature) which can be easily removed from reaction mask.

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