Convenient and Efficient Synthesis of Thiol Esters using Zinc Oxide as a Heterogeneous and Eco-Friendly Catalyst

2008 ◽  
Vol 61 (12) ◽  
pp. 1006 ◽  
Author(s):  
Babasaheb Pandurang Bandgar ◽  
Parmeshwar Eknath More ◽  
Vinod Tribhuvannathji Kamble ◽  
Sanjay Suresh Sawant
Keyword(s):  
Zinc Oxide ◽  
Reaction Time ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Catalytic Method ◽  
Reaction Conditions ◽  
Acyl Chlorides ◽  
Short Reaction Time ◽  
Thiol Esters ◽  
Solvent Free Conditions

A catalytic method was developed to synthesize thiol esters from the reaction of acyl chlorides and thiols using zinc oxide as a catalyst under solvent-free conditions at room temperature. Mild reaction conditions, short reaction time, excellent yields of products and recyclability of the catalyst are noteworthy features of this methodology.

Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature

Synlett ◽  
2018 ◽  
Vol 29 (20) ◽  
pp. 2689-2692 ◽  
Author(s):  
Haifeng Wang ◽  
Xiangli Sun ◽  
Shuangling Zhang ◽  
Guanglu Liu ◽  
Chunjie Wang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Catalytic System ◽  
Efficient Method ◽  
Room Temperature ◽  
Copper Catalyst ◽  
Condensation Reaction ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Acid Catalyzed ◽  
Substituted Pyrazoles

An efficient method for the synthesis of pyrazoles through a copper-catalyzed condensation reaction has been developed. The new catalytic system not only maintained a broad substrate scope but was also active under acid-free reaction conditions, overcoming the conventional requirement for an acid-catalyzed system. Furthermore, the copper catalyst enabled this reaction to be performed at room temperature and in a short reaction time.

Rapid synthesis of homoallylic alcohol from aldehyde with allyltributylstannane under solvent-free conditions

2012 ◽  
Vol 90 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Pranjal P. Bora ◽  
H. Atoholi Sema ◽  
Barisha Wahlang ◽  
Ghanashyam Bez
Keyword(s):  
Reaction Time ◽  
Phosphotungstic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Solvent Free Reaction

A catalytic amount (2 mol %) of phosphotungstic acid (PTA) is sufficient to synthesize homoallylic alcohol in excellent yields from aldehyde with allyltributylstannane upon grinding under solvent-free reaction conditions. Easy handling, very short reaction time, solvent-free reaction conditions, and aqueous workup free isolation protocol may make our method very useful for synthetic chemists.

scholarly journals A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Amulrao Borse ◽  
Mahesh Patil ◽  
Nilesh Patil ◽  
Rohan Shinde
Keyword(s):  
Reaction Time ◽  
Ambient Temperature ◽  
Room Temperature ◽  
Simple Procedure ◽  
Methanesulfonic Acid ◽  
Phosphorus Pentoxide ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton’s reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

2020 ◽  
Vol 17 (5) ◽  
pp. 403-407
Author(s):  
Rui Du ◽  
Liangliang Han ◽  
Zhongqiang Zhou ◽  
Victor Borovkov
Keyword(s):  
Reaction Time ◽  
Multicomponent Reaction ◽  
Room Temperature ◽  
Reaction Rates ◽  
Solvent Free ◽  
Hydroxyl Group ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

A clean, simple and efficient synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h] quinolin-2-yl]-(4-chlorophenyl)methanones

2017 ◽  
Vol 41 (7) ◽  
pp. 380-383
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Reaction Time ◽  
Green Chemistry ◽  
Aromatic Aldehyde ◽  
Efficient Method ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
High Yields

We report a green and efficient method for the synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2- h]quinolin-2-yl]-(4-chlorophenyl) methanones from the condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 8-hydroxyquinoline and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water at reflux conditions. This new protocol employing choline hydroxide, which is a green and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction time, high yields and does not involve any hazardous solvent. Therefore, this procedure can be classified as green chemistry.

Cyanuric Chloride: an Efficient Catalyst for Ring Opening of Epoxides with Thiols Under Solvent-Free Conditions

2008 ◽  
Vol 61 (3) ◽  
pp. 231 ◽  
Author(s):  
Babasaheb P. Bandgar ◽  
Neeta S. Joshi ◽  
Vinod T. Kamble ◽  
Sanjay S. Sawant
Keyword(s):  
Reaction Time ◽  
Ring Opening ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Reaction Conditions ◽  
Efficient Catalyst ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides

2,4,6-Trichloro-1,3,5-triazine-catalyzed convenient and efficient ring opening of epoxides with thiols under solvent-free conditions is described. Short reaction time, mild reaction conditions, inexpensive and readily available catalyst, and excellent yields of products are attractive features of this methodology.

Phenyl boronic acid promoted efficient synthesis of perimidine derivatives under mild condition

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Reaction Time ◽  
Mild Condition ◽  
Boronic Acid ◽  
Catalytic Amount ◽  
Product Yield ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Good Product ◽  
Phenyl Boronic Acid

Various biologically important perimidines derivatives have been efficiently synthesized in excellent from Napthalene-1,8-diamine and various ketones in presence of a catalytic amount of Phenyl boronic acid. This approach offers many advantages such as good product yield, short reaction time, easy isolation of products and mild reaction conditions.

scholarly journals One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

2005 ◽  
Vol 2 (4) ◽  
pp. 228-230 ◽  
Author(s):  
Jin Tong-Shou ◽  
Zhao Ying ◽  
Liu Li-Bin ◽  
Li Tong-Shuang
Keyword(s):  
Reaction Time ◽  
Biginelli Reaction ◽  
Chlorosulfonic Acid ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Short Reaction Time ◽  
One Pot Synthesis

An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.

Rapid and Efficient Coupling Reaction of Azo Dyes in a Continuous-Flow Microreactor

2012 ◽  
Vol 560-561 ◽  
pp. 516-520
Author(s):  
Wu Bin Yu ◽  
Ming Ming Zheng ◽  
Jian Rong Gao
Keyword(s):  
Reaction Time ◽  
Azo Dyes ◽  
Continuous Flow ◽  
Room Temperature ◽  
High Efficiency ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Flow Microreactor ◽  
Efficient Coupling

A convenient, rapid efficient method for the synthesis of azo dyes has been developed by coupling in a continuous-flow microreactor at room temperature. The advantage of this protocol is its continuousness, high efficiency and selectivity, short reaction time, and milder reaction conditions.

Solvent-free, Silica Catalyzed Intriguing Conversion of 3-Hydrazonobutan-2-one Oxime into Biacetyl Bis-hydrazone Schiff Bases

2020 ◽  
Vol 17 ◽  
Author(s):  
Ranjana Aggarwal ◽  
Mona Hooda ◽  
Prince Kumar ◽  
Garima Sumran
Keyword(s):  
Reaction Time ◽  
Schiff Bases ◽  
Good Yield ◽  
Room Temperature ◽  
Environmentally Benign ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Free Silica ◽  
Elemental Analyses ◽  
Unexpected Product

: An expeditious and operationally simple reaction between 3-hydrazonobutan-2-one oxime and different substituted benzaldehydes in presence of silica afforded an unexpected product, biacetyl bis-hydrazone Schiff bases in good yield on grinding in a mortar at room temperature, instead of expected product 3-(aryl)methylenehydrazonobutan-2-one oxime. Mild reaction conditions involving recyclable mineral support silica, environmentally benign and good yield in short reaction time are remarkable advantages of this protocol. Products were characterized by IR, NMR (1H and 13C) and elemental analyses.

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