scholarly journals A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1909 ◽  
Author(s):  
Nagaraju Kerru ◽  
Lalitha Gummidi ◽  
Suresh Maddila ◽  
Kranthi Kumar Gangu ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Biological Applications ◽  
Valuable Source ◽  
The Past ◽  
Recent Advances ◽  
Physiological Properties ◽  
One Year

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.

scholarly journals A Review on Six Membered Nitrogen Containing Heterocyclic Compounds with Various Biological Activities

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Meenu C Sanu ◽  
Jincy Joseph ◽  
Divya Chacko
Keyword(s):  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Pharmacological Activities ◽  
Valuable Source ◽  
Physiological Properties ◽  
Novel Therapeutic

The heterocycles are currently considered as promising compounds for the development of novel therapeutic agents. The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. This paper aims to review on the pharmacological activities of six membered nitrogen contains heterocyclic compounds.

1,8-naphthyridine derivatives: an updated review on recent advancements of their myriad biological activities

2021 ◽  
Author(s):  
Shivani Mithula ◽  
Adinarayana Nandikolla ◽  
Sankaranarayanan Murugesan ◽  
Venkata GCS Kondapalli
Keyword(s):  
Drug Discovery ◽  
Broad Spectrum ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
The Past ◽  
Anti Hiv ◽  
Past Half ◽  
Half Decade

Among all nitrogen-containing heterocycles, the 1,8-naphthyridine scaffold has recently gained an immense amount of curiosity from numerous researchers across fields of medicinal chemistry and drug discovery. This new attention can be ascribed to its versatility of synthesis, its reactiveness and the variety of biological activities it has exhibited. Over the past half-decade, numerous diverse biological evaluations have been conducted on 1,8-naphthyridine and its derivatives in a quest to unravel novel pharmacological facets to this scaffold. Its potency to treat neurodegenerative and immunomodulatory disorders, along with its anti-HIV, antidepressant and antioxidant properties, has enticed researchers to look beyond its broad-spectrum activities, providing further scope for exploration. This review is a consolidated update of previous works on 1,8-naphthyridines and their analogs, focusing on the past 5 years.

scholarly journals Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

Marine Drugs ◽  
2013 ◽  
Vol 11 (1) ◽  
pp. 233-252 ◽  
Author(s):  
Maria Raposo ◽  
Rui De Morais ◽  
Alcina Bernardo de Morais
Keyword(s):  
Biological Activities ◽  
Surrounding Medium ◽  
Therapeutic Agents ◽  
Marine Microalgae ◽  
Extracellular Polysaccharides ◽  
Biological Applications ◽  
Sulphated Polysaccharides ◽  
Unicellular Algae ◽  
Long Time ◽  
The Times

Marine microalgae have been used for a long time as food for humans, such as Arthrospira (formerly, Spirulina), and for animals in aquaculture. The biomass of these microalgae and the compounds they produce have been shown to possess several biological applications with numerous health benefits. The present review puts up-to-date the research on the biological activities and applications of polysaccharides, active biocompounds synthesized by marine unicellular algae, which are, most of the times, released into the surrounding medium (exo- or extracellular polysaccharides, EPS). It goes through the most studied activities of sulphated polysaccharides (sPS) or their derivatives, but also highlights lesser known applications as hypolipidaemic or hypoglycaemic, or as biolubricant agents and drag-reducers. Therefore, the great potentials of sPS from marine microalgae to be used as nutraceuticals, therapeutic agents, cosmetics, or in other areas, such as engineering, are approached in this review.

Boron in drug design: Recent advances in the development of new therapeutic agents

2019 ◽  
Vol 179 ◽  
pp. 791-804 ◽  
Author(s):  
Guilherme Felipe Santos Fernandes ◽  
William Alexander Denny ◽  
Jean Leandro Dos Santos
Keyword(s):  
Drug Design ◽  
Therapeutic Agents ◽  
Recent Advances

scholarly journals Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2783 ◽  
Author(s):  
Shu-Guang Zhang ◽  
Chao-Gen Liang ◽  
Wei-Hua Zhang
Keyword(s):  
Functional Groups ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Drug Molecules ◽  
Recent Advances

Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. Diversely substituted indazole derivatives bear a variety of functional groups and display versatile biological activities; hence, they have gained considerable attention in the field of medicinal chemistry. This review aims to summarize the recent advances in various methods for the synthesis of indazole derivatives. The current developments in the biological activities of indazole-based compounds are also presented.

Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

2015 ◽  
Vol 13 (12) ◽  
pp. 3525-3555 ◽  
Author(s):  
Richa Goel ◽  
Vijay Luxami ◽  
Kamaldeep Paul
Keyword(s):  
Biological Activities ◽  
Biological Applications ◽  
Recent Advances

The synthesis, reactivity and multifarious biological activities at the different positions of imidazo[1,2-a]pyrazines are concisely discussed in this review.

Quinoline: an attractive scaffold in drug design

2021 ◽  
Vol 21 ◽  
Author(s):  
Lucas F. E. Moor ◽  
Thatyana R. A. Vasconcelos ◽  
Raisa da R. Reis ◽  
Ligia S. S. Pinto ◽  
Thamires M. da Costa
Keyword(s):  
Side Effects ◽  
Drug Design ◽  
Heterocyclic Compounds ◽  
Rational Design ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Bioactive Molecules ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range

: Quinoline and its derivatives comprise an important group of heterocyclic compounds that exhibits a wide range of pharmacological properties such as antibacterial, antiviral, anticancer, antiparasitic, anti-Alzheimer and anticholesterol. In fact, the quinoline nucleus is found in the structure of many drugs and in rational design in medicinal chemistry for the discovery of novel bioactive molecules. Persistent efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. This review highlights some discoveries on the development of quinoline-based compounds in recent years (2013-2019) focusing on their biological activities, including anticancer, antitubercular, antimalarial, anti-ZIKV, anti-DENV, anti-Leishmania and anti-Alzheimer’s disease.

scholarly journals Recent Advances in Catalytic Synthesis of Benzosultams

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4367
Author(s):  
Quan-Qing Zhao ◽  
Xiao-Qiang Hu
Keyword(s):  
Medicinal Chemistry ◽  
Catalytic Synthesis ◽  
Chiral Catalysts ◽  
Catalytic Systems ◽  
The Past ◽  
Recent Advances ◽  
Efficient Construction

Benzosultams represent one category of multi-heteroatom heterocyclic scaffolds, which have been frequently found in pharmaceuticals, agricultural agents, and chiral catalysts. Given the diversely significant functions of these compounds in organic and medicinal chemistry, great efforts have been made to develop novel catalytic systems for the efficient construction of benzosultam motifs over the past decades. Herein, in this review, we mainly summarize the recent advances in the field of catalytic synthesis of benzosultams from 2017 to August of 2020, with an emphasis on the scopes and mechanisms of representative reactions.

Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article)

2012 ◽  
Vol 84 (7) ◽  
pp. 1479-1542 ◽  
Author(s):  
Mohammad H. El-Dakdouki ◽  
Paul W. Erhardt
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Medicinal Chemistry ◽  
Drug Distribution ◽  
Therapeutic Agents ◽  
Special Topic ◽  
Design Strategies ◽  
Basic Principles ◽  
Research Activities ◽  
Alternative Drug

The benefits of utilizing marketed drugs as starting points to discover new therapeutic agents have been well documented within the IUPAC series of books that bear the title Analogue-based Drug Discovery (ABDD). Not as clearly demonstrated, however, is that ABDD also contributes to the elaboration of new basic principles and alternative drug design strategies that are useful to the field of medicinal chemistry in general. After reviewing the ABDD programs that have evolved around the area of microtubule-stabilizing chemo-therapeutic agents, the present article delineates the associated research activities that additionally contributed to general strategies that can be useful for prodrug design, identifying pharmacophores, circumventing multidrug resistance (MDR), and achieving targeted drug distribution.

scholarly journals Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides

2018 ◽  
Vol 14 ◽  
pp. 772-785 ◽  
Author(s):  
Kartik Temburnikar ◽  
Katherine L Seley-Radtke
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Nucleophilic Substitution ◽  
Medicinal Chemistry ◽  
Structural Diversity ◽  
Synthetic Analogues ◽  
Structural Modifications ◽  
Modular Synthesis ◽  
Recent Advances ◽  
Synthetic Approaches

C-nucleosides have intrigued biologists and medicinal chemists since their discovery in 1950's. In that regard, C-nucleosides and their synthetic analogues have resulted in promising leads in drug design. Concurrently, advances in chemical syntheses have contributed to structural diversity and drug discovery efforts. Convergent and modular approaches to synthesis have garnered much attention in this regard. Among them nucleophilic substitution at C1' has seen wide applications providing flexibility in synthesis, good yields, the ability to maneuver stereochemistry as well as to incorporate structural modifications. In this review, we describe recent reports on the modular synthesis of C-nucleosides with a focus on D-ribonolactone and sugar modifications that have resulted in potent lead molecules.

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