scholarly journals Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1826 ◽  
Author(s):  
Alexander N. Shikov ◽  
Vera M. Kosman ◽  
Elena V. Flissyuk ◽  
Irina E. Smekhova ◽  
Abdelhameed Elameen ◽  
...  
Keyword(s):  
Particle Size ◽  
Water Content ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Rhodiola Rosea ◽  
Extraction Temperature ◽  
Natural Deep Eutectic Solvents ◽  
Predicted Values ◽  
Natural Deep Eutectic Solvent

The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 °C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5–1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.

scholarly journals Natural Deep Eutectic Solvents as Sustainable Solvents for Suzuki­–Miyaura Cross-Coupling Reactions Applied to Imidazo-Fused Heterocycles

SynOpen ◽  
2018 ◽  
Vol 02 (04) ◽  
pp. 0306-0311 ◽  
Author(s):  
Pierre-Olivier Delaye ◽  
Mélanie Pénichon ◽  
Leslie Boudesocque-Delaye ◽  
Cécile Enguehard-Gueiffier ◽  
Alain Gueiffier
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Cross Coupling ◽  
Deep Eutectic Solvents ◽  
Coupling Reactions ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Fused Heterocycles ◽  
Natural Deep Eutectic Solvents ◽  
Natural Deep Eutectic Solvent

Herein, we present the first Suzuki–Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)2. Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.

scholarly journals Preparation of Readily-to-Use Stilbenoids Extract from Morus alba Callus Using a Natural Deep Eutectic Solvent

Cosmetics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 91
Author(s):  
Jukrapun Komaikul ◽  
Supachoke Mangmool ◽  
Waraporn Putalun ◽  
Tharita Kitisripanya
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Dry Weight ◽  
Deep Eutectic Solvents ◽  
Morus Alba ◽  
Green Solvent ◽  
Natural Deep Eutectic Solvents ◽  
Significant Difference ◽  
Natural Deep Eutectic Solvent ◽  
Skin Lightening

The consumer and cosmetic industries have recently placed a greater emphasis on ecofriendly solvents for botanical extraction, including natural deep eutectic solvents (NADES). In this study, NADES were prepared for Morus alba callus extraction. The efficiency of extraction from the NADES and methanol was investigated by comparison of the stilbenoids yield and anti-melanogenesis activity. Prior to testing the irritability of a suitable NADES on the reconstructed human epidermis (RhE), the effect of the selected NADES on stilbenoids stability was determined. The results showed that the highest yields of stilbenoids were obtained from choline chloride-glycerol mixtures (Ch1G2) and methanol extracts, with no significant difference in yields (5.06 ± 0.05 and 6.32 ± 0.40 mg/g callus dry weight, respectively). The NADES extracts of M. alba callus showed comparable anti-melanogenesis activity compared to methanol. In term of stability, stilbenoids in Ch1G2 remained stable after six months of storage at 4 °C except resveratrol. Furthermore, Ch1G2 had no irritation effect on RhE. Thus, based on the findings of this study, Ch1G2 is an intriguing green solvent alternative for the extraction of M. alba callus and may be advantageous for the preparation of skin-lightening cosmetics.

scholarly journals Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 513 ◽  
Author(s):  
Sonia Bonacci ◽  
Maria Luisa Di Gioia ◽  
Paola Costanzo ◽  
Loredana Maiuolo ◽  
Sofia Tallarico ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Olive Oil ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Process ◽  
Oil Processing ◽  
Flight Mass Spectrometry ◽  
Natural Deep Eutectic Solvents ◽  
Processing Wastes ◽  
Natural Deep Eutectic Solvent

In this new century, sustainable development challenges chemical sciences to develop new and clean technological processes. The agri-food industry produces significant quantities of waste, raising significant economic and environmental concerns. Food waste valorization using environmentally friendly procedures is of increasing importance. This study describes the use of several Natural Deep Eutectic Solvents (NADESs) for the microwave-assisted extraction (MAE) of valuable bioactive phenolic compounds from olive oil processing wastes. The extracted samples were characterized by liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF/MS) analysis and the quantification of the phenolic compounds was performed by HPLC analysis. The obtained data were compared with those obtained using water as the solvent in the same extraction conditions. The extraction process is nontoxic, simple and selective and meets most of the criteria to be considered as a sustainable process, with the solvents arising directly from nature.

scholarly journals Biocompatible natural deep eutectic solvent-based extraction and cellulolytic enzyme-mediated transformation of Pueraria mirifica isoflavones: a sustainable approach for increasing health-bioactive constituents

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Fonthip Makkliang ◽  
Boondaree Siriwarin ◽  
Gorawit Yusakul ◽  
Suppalak Phaisan ◽  
Attapon Sakdamas ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Cellulolytic Enzymes ◽  
Cellulolytic Enzyme ◽  
Optimal Conditions ◽  
Bioactive Constituents ◽  
Pueraria Mirifica ◽  
Assisted Extraction ◽  
Natural Deep Eutectic Solvents ◽  
Natural Deep Eutectic Solvent

AbstractThe presence of specific gut microflora limits the biotransformation of Pueraria mirifica isoflavone (PMI) glycosides into absorbable aglycones, thus limiting their health benefits. Cellulolytic enzyme-assisted extraction (CAE) potentially solves this issue; however, solvent extraction requires recovery of the hydrophobic products. Here, we established the simultaneous transformation and extraction of PMIs using cellulolytic enzymes and natural deep eutectic solvents (NADESs). The NADES compositions were optimized to allow the use of NADESs as CAE media, and the extraction parameters were optimized using response surface methodology (RSM). The optimal conditions were 14.7% (v/v) choline chloride:propylene glycol (1:2 mol ratio, ChCl:PG) at 56.1 °C for the cellulolytic enzyme (262 mU/mL) reaction in which daidzin and genistin were extracted and wholly transformed to their aglycones daidzein and genistein. The extraction of PMIs using ChCl:PG is more efficient than that using conventional solvents; additionally, biocompatible ChCl:PG enhances cellulolytic enzyme activity, catalyzing the transformation of PMIs into compounds with higher estrogenicity and absorbability.

scholarly journals Optimization of Supercritical Carbon Dioxide Extraction of Quercus infectoria Oil

2015 ◽  
Vol 74 (7) ◽  
Author(s):  
Liza Md Salleh ◽  
Stashia ELeaness Rosland Abel ◽  
Gholamreza Zahedi ◽  
Russly Abd Rahman ◽  
Hasmida Mohd Nasir ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Goodness Of Fit ◽  
Maximum Yield ◽  
Extraction Yield ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Predicted Values ◽  
Artificial Neural Network Ann ◽  
Quercus Infectoria

This current study focuses on the modelling and optimization of supercritical fluid extraction of Quercus infectoria galls oil. In this case, response surface methodology (RSM) and artificial neural network (ANN) were applied for the modelling and prediction of extraction yield of galls oil. A 17-run Box-Behnken Design (BBD) was employed to statistically optimize the process parameters of SC-CO2 extraction of Quercus infectoria galls at a condition as follows: pressure (5000, 6000, 7000 Psi), temperature (40, 50, 60°C) and extraction time (30, 45, 60 min). The maximum yield of the extracted oil is1.12 % and the optimum conditions are at an extraction pressure of 5574 Psi; extraction temperature of 75°C and extraction time of 54 min. Under the optimal conditions, the experimental results agree with the predicted values obtained through analysis of variance (ANOVA). This indicates a successful response surface methodology and highly satisfactory goodness of fit of the model used. The analysis of experimental design for process optimization results demonstrates that temperature and extraction time are the main parameters that influence the oil extraction of Quercus infectoria.

scholarly journals Deep Eutectic Solvent-Based Microwave-Assisted Extraction of Baicalin from Scutellaria baicalensis Georgi

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Hui Wang ◽  
Xiaodi Ma ◽  
Qibin Cheng ◽  
Xiaoli Xi ◽  
Liwei Zhang
Keyword(s):  
Maximum Yield ◽  
Deep Eutectic Solvent ◽  
Extraction Yield ◽  
Scutellaria Baicalensis ◽  
Molar Ratio ◽  
Extraction Temperature ◽  
Microwave Assisted Extraction ◽  
Scutellaria Baicalensis Georgi ◽  
Microwave Assisted ◽  
Assisted Extraction

Deep eutectic solvents (DESs) have attracted significant attention as green media for the extraction and separation of natural compounds from Chinese medicine. In this study, a hydrophobic DESs-based microwave-assisted extraction (MAE) was successfully used to efficiently extract baicalin from Scutellaria baicalensis Georgi. Firstly, DecA: N4444-Cl (DES-1 , molar ratio 1 : 2) was screened and selected as the most appropriate DES by comparing the extraction yield in different hydrophobic DESs. Based on the extraction yield of baicalin, response surface methodology (RSM) was employed to model and optimize the parameters (extraction temperature, liquid-solid ratio, and extraction time). Furthermore, the maximum yield of 106.96 mg·g−1 was achieved under optimum conditions in DES-containing aqueous solutions (33 vol% water content), which reached a similar level that was conducted using the pharmacopoeia procedure (104.94 mg·g−1). These results indicated that the proposed method is an excellent alternative for the extraction of baicalin.

Influence of temperature, water content and type of organic acid on the formation, stability and properties of functional natural deep eutectic solvents

2019 ◽  
Vol 488 ◽  
pp. 40-47 ◽  
Author(s):  
Lizandra Kamradt Savi ◽  
Danielle Carpiné ◽  
Nina Waszczynskyj ◽  
Rosemary Hoffmann Ribani ◽  
Charles Windson Isidoro Haminiuk
Keyword(s):  
Organic Acid ◽  
Water Content ◽  
Deep Eutectic Solvents ◽  
Influence Of Temperature ◽  
Natural Deep Eutectic Solvents ◽  
Temperature Water

scholarly journals Green and Efficient Extraction of Polysaccharides From Poria cocos F.A. Wolf by Deep Eutectic Solvent

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X1990070 ◽  
Author(s):  
Weida Zhang ◽  
Shaobo Cheng ◽  
Xiaona Zhai ◽  
Junshe Sun ◽  
Xuefang Hu ◽  
...  
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Hot Water ◽  
Poria Cocos ◽  
Extraction Solvent ◽  
Molecular Weight Distributions ◽  
Efficient Extraction ◽  
Run Test

Deep eutectic solvents (DESs) were proposed for the extraction of polysaccharides from Poria cocos (PCPs). Six types of DESs were prepared, and the DES composed of choline chloride and oxalic acid was proved to be suitable. Based on the results of single-factor test, the Box-Behnken experimental design with response surface methodology was carried out, giving the optimal extraction conditions including mole ratio of 1:2 (choline chloride:oxalic acid) and extraction 15 minutes at 100°C. Under the optimal extraction conditions, the extraction yield (46.24% ± 0.13%) was 8.6 times higher than that of hot water. The reusability of DES was demonstrated by a 6-run test, and an extraction yield of PCP was 38.40% ± 0.23% after reusing for 6 times without adding any additional chemicals. Moreover, molecular weight distributions of the resulting PCP were analyzed, and then mainly distributed in the range of 753 to 3578 g/mol. Therefore, DESs were proved to be an excellent extraction solvent alternative to the extraction of PCP.

scholarly journals A brief review on eutectic mixture and its role in pharmaceutical field

2020 ◽  
Vol 11 (3) ◽  
pp. 3017-3023
Author(s):  
Balakrishnan I ◽  
Jawahar N ◽  
Senthil Venkatachalam ◽  
Debosmita Datta
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bond ◽  
Deep Eutectic Solvent ◽  
Eutectic Mixture ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Liquid Form ◽  
Hydrogen Bond Acceptor ◽  
Pharmaceutical Industries ◽  
Natural Deep Eutectic Solvent

Eutectic mixture (EM) is as a mixture of more than one substance that does not interact individually to create a new entity but in a particular ratio that exhibits a lower range of melting point than it had in individual. EM should be formulated in such a way that it should have major advantages in pharmaceutical industries. EM can be a mixture of Active Pharmaceutical Ingredients (APIs), or different ratios of APIs and excipients, or various excipients. Deep eutectic solvents containing APIs (API-DES) considered as an innovative approach to form different APIs in the liquid state. This new approach of liquid form is versatile and plays an important role in drug delivery. The selection of ideal hydrogen bond-donor (HBD) and hydrogen bond-acceptor (HBA) is an essential parameter. Ionic liquids (IL), derivatives of deep eutectic solvents (DES) have got much attention since it can replace harmful organic solvent by their extraordinary properties. Therapeutic deep eutectic solvents (THEDESs) are considered to be an exceptional option in the advancement of biomedicine. This can be utilized for improvising drug solubility, bioavailability as well as drug permeation through the skin. Natural deep eutectic solvent (NADES) can be considered as an alternate option, replacing harsh solvents. It has special characteristics of better biodegradability and biocompatibility. These NADES mainly used to separate and purification of natural compounds. This review focuses on the eutectic mixture and its application in the area of drug delivery systems, and pharmaceutical and pharmacological fields.

scholarly journals Crustacean shell bio-refining to chitin by natural deep eutectic solvents

2019 ◽  
Vol 9 (1) ◽  
pp. 13-25 ◽  
Author(s):  
Bojana Bradić ◽  
Uroš Novak ◽  
Blaž Likozar
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Added Value ◽  
Biomass Waste ◽  
Complete Evaluation ◽  
Natural Deep Eutectic Solvents ◽  
Shrimp Shell ◽  
Chitin Extraction ◽  
On Line

AbstractThis study provides a complete evaluation of a sustainable zero-waste process for the recovery of added value biomaterials from the abundant shrimp shell biomass waste using natural deep eutectic solvents (NADES). The process parameters for the fractionation of α-chitin, minerals and protein was followed using on-line measurements. Furthermore, the quantitative analysis of isolated chitin, minerals and solvent waste streams were examined. The dominant fractionation mechanisms are explained through the analysis of the liquid and solid fractions. Four of the most promising, and commercially available, NADES consisting on mixtures of Choline Chloride-Lactic Acid (CCLA), Choline Chloride-Malonic Acid (CCMA), Choline Chloride-Urea (CCUR) and Choline Chloride-Citric Acid (CCCA), were tested. The highest chitin extraction yield obtained was < 90% using CCLA, leading to purity higher than 98%. Moreover, it is possible to recycle this particular NADES several times, while having no loss in the shrimp shell fractionation capability.

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