scholarly journals Preparation of Readily-to-Use Stilbenoids Extract from Morus alba Callus Using a Natural Deep Eutectic Solvent

Cosmetics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 91
Author(s):  
Jukrapun Komaikul ◽  
Supachoke Mangmool ◽  
Waraporn Putalun ◽  
Tharita Kitisripanya
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Dry Weight ◽  
Deep Eutectic Solvents ◽  
Morus Alba ◽  
Green Solvent ◽  
Natural Deep Eutectic Solvents ◽  
Significant Difference ◽  
Natural Deep Eutectic Solvent ◽  
Skin Lightening

The consumer and cosmetic industries have recently placed a greater emphasis on ecofriendly solvents for botanical extraction, including natural deep eutectic solvents (NADES). In this study, NADES were prepared for Morus alba callus extraction. The efficiency of extraction from the NADES and methanol was investigated by comparison of the stilbenoids yield and anti-melanogenesis activity. Prior to testing the irritability of a suitable NADES on the reconstructed human epidermis (RhE), the effect of the selected NADES on stilbenoids stability was determined. The results showed that the highest yields of stilbenoids were obtained from choline chloride-glycerol mixtures (Ch1G2) and methanol extracts, with no significant difference in yields (5.06 ± 0.05 and 6.32 ± 0.40 mg/g callus dry weight, respectively). The NADES extracts of M. alba callus showed comparable anti-melanogenesis activity compared to methanol. In term of stability, stilbenoids in Ch1G2 remained stable after six months of storage at 4 °C except resveratrol. Furthermore, Ch1G2 had no irritation effect on RhE. Thus, based on the findings of this study, Ch1G2 is an intriguing green solvent alternative for the extraction of M. alba callus and may be advantageous for the preparation of skin-lightening cosmetics.

scholarly journals Natural Deep Eutectic Solvents as Sustainable Solvents for Suzuki­–Miyaura Cross-Coupling Reactions Applied to Imidazo-Fused Heterocycles

SynOpen ◽  
2018 ◽  
Vol 02 (04) ◽  
pp. 0306-0311 ◽  
Author(s):  
Pierre-Olivier Delaye ◽  
Mélanie Pénichon ◽  
Leslie Boudesocque-Delaye ◽  
Cécile Enguehard-Gueiffier ◽  
Alain Gueiffier
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Cross Coupling ◽  
Deep Eutectic Solvents ◽  
Coupling Reactions ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Fused Heterocycles ◽  
Natural Deep Eutectic Solvents ◽  
Natural Deep Eutectic Solvent

Herein, we present the first Suzuki–Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)2. Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.

scholarly journals Natural Deep Eutectic Solvent-Assisted Pectin Extraction from Pomelo Peel Using Sonoreactor: Experimental Optimization Approach

Processes ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 416 ◽  
Author(s):  
Amal Elgharbawy ◽  
Adeeb Hayyan ◽  
Maan Hayyan ◽  
Mohamed Mirghani ◽  
Hamzah Salleh ◽  
...  
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Optimization Approach ◽  
Degree Of Esterification ◽  
Screening Design ◽  
Natural Deep Eutectic Solvents ◽  
Wide Range ◽  
Definitive Screening ◽  
Water Ratio

Background: Natural deep eutectic solvents (NADESs) can be used for extracting a wide range of biomaterials, such as pectin. This study introduces a new generation of natural solvents for pectin extraction which could replace the conventional solvents in the food industry. Methods: In this study, NADESs were used for pectin extraction from pomelo (Citrus grandis (L.) Osbeck) peels using a sonoreactor. Definitive screening design (DSD) was used to screen the influence of time, temperature, solid/liquid ratio, and NADES/water ratio on the pectin yield and degree of esterification (DE). Results: The primary screening revealed that the best choices for the extraction were choline chloride–malonic acid (ChCl-Mal) and choline chloride–glucose–water (ChCl:Glc:W). Both co-solvents yielded 94% pectin and 52% DE after optimization at 80 °C, with 60 min of sonication, pH < 3.0, and a NADES-to-water ratio of 1:4.5 (v/v). Morphological screening showed a smooth and compact surface of the pectin from ChCl-Mal where glucose-based pectin had a rough surface and lower DE. Conclusions: NADESs proved to be promising co-solvents for pectin extraction with a high degree of esterification (>55%).

scholarly journals Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1826 ◽  
Author(s):  
Alexander N. Shikov ◽  
Vera M. Kosman ◽  
Elena V. Flissyuk ◽  
Irina E. Smekhova ◽  
Abdelhameed Elameen ◽  
...  
Keyword(s):  
Particle Size ◽  
Water Content ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Rhodiola Rosea ◽  
Extraction Temperature ◽  
Natural Deep Eutectic Solvents ◽  
Predicted Values ◽  
Natural Deep Eutectic Solvent

The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 °C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5–1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.

scholarly journals Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 513 ◽  
Author(s):  
Sonia Bonacci ◽  
Maria Luisa Di Gioia ◽  
Paola Costanzo ◽  
Loredana Maiuolo ◽  
Sofia Tallarico ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Olive Oil ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Process ◽  
Oil Processing ◽  
Flight Mass Spectrometry ◽  
Natural Deep Eutectic Solvents ◽  
Processing Wastes ◽  
Natural Deep Eutectic Solvent

In this new century, sustainable development challenges chemical sciences to develop new and clean technological processes. The agri-food industry produces significant quantities of waste, raising significant economic and environmental concerns. Food waste valorization using environmentally friendly procedures is of increasing importance. This study describes the use of several Natural Deep Eutectic Solvents (NADESs) for the microwave-assisted extraction (MAE) of valuable bioactive phenolic compounds from olive oil processing wastes. The extracted samples were characterized by liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF/MS) analysis and the quantification of the phenolic compounds was performed by HPLC analysis. The obtained data were compared with those obtained using water as the solvent in the same extraction conditions. The extraction process is nontoxic, simple and selective and meets most of the criteria to be considered as a sustainable process, with the solvents arising directly from nature.

scholarly journals Deep eutectic solvent pretreatment for enhancing biochemical conversion of switchgrass

2017 ◽  
Author(s):  
◽  
Maryam Al Ameri
Keyword(s):  
Hydrogen Bond ◽  
Acetic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Green Solvent ◽  
Biomass Recalcitrance ◽  
Hydrogen Bond Donor ◽  
Excellent Performance ◽  
Hydrogen Bond Acceptor

In this study, green solvent-based pretreatment was developed for improving the conversion of switchgrass to acetoin. Deep eutectic solvents (DESs), comprising choline chloride (ChCl) as a hydrogen-bond acceptor (HBA) and various chemical as a hydrogen-bond donor (HBD), were used to pretreat switchgrass. Different HBD groups, including polyalcohol, amid, diazole, and carboxylic acid, were used to synthesize DESs. The DESs using ChCl-formic acid and ChCl-lactic acid-acetic acid showed excellent performance in enhancing switchgrass digestibility. The obtained hydrolysate was successfully detoxified by using overliming detoxification, which was further used for acetoin fermentation by Bacillus licheniformis (NRRL B-642). The yield and titer of the produced acetoin were 0.377 g/g and 19.6 g/L, respectively. Our research demonstrates that DES pretreatment is an effective method for reducing biomass recalcitrance and improving the conversion of biomass into chemicals.

scholarly journals Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1619 ◽  
Author(s):  
Maša Islamčević Razboršek ◽  
Milena Ivanović ◽  
Peter Krajnc ◽  
Mitja Kolar
Keyword(s):  
Hydrogen Bond ◽  
Phenolic Compounds ◽  
Choline Chloride ◽  
Dry Weight ◽  
Deep Eutectic Solvents ◽  
Ultrasound Assisted Extraction ◽  
Hydrogen Bond Acceptor ◽  
Mean Values ◽  
Natural Deep Eutectic Solvents ◽  
The Individual

For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total flavonoids were found in the extract obtained with choline chloride–fructose NADES (36.15 ± 3.39 mg gallic acid g−1 dry weight (DW) and 4.71 ± 0.33 mg rutin g−1 DW, respectively). The extraction recoveries for the individual phenolic compounds depended strongly on the phenolic compound’s structure, with relative mean values between 70% and 97%.

scholarly journals Effect of Choline-Based Deep Eutectic Solvent Pretreatment on the Structure of Cellulose and Lignin in Bagasse

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 384
Author(s):  
Cuicui Li ◽  
Chongxing Huang ◽  
Yuan Zhao ◽  
Chaojian Zheng ◽  
Hongxia Su ◽  
...  
Keyword(s):  
Low Cost ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Crystalline Cellulose ◽  
Cellulose Ii ◽  
Green Solvent ◽  
Syringyl Lignin ◽  
Guaiacyl Lignin ◽  
Bagasse Fiber

Deep eutectic solvents (DESs) is a newly developed green solvent with low cost, easy preparation and regeneration. Because of its excellent solubility and swelling effect in lignocellulose, it has received widespread attention and recognition. In this study, choline-based deep eutectic solvents (DESs)—choline chloride-urea (CC-U), choline chloride-ethylene glycol (CC-EG), choline chloride-glycerol (CC-G), choline chloride-lactic acid (CC-LA), and choline chloride-oxalic acid (CC-OA)—were used to extract and separate bagasse. The effects of hydrogen bond donors on lignin separation and the fiber and lignin structure were investigated. All five DESs could dissolve lignin from bagasse; acidic DESs exhibited higher solubility than basic DESs. CC-OA effectively separated lignin and hemicellulose. CC-LA showed weaker lignin separation ability than CC-OA. CC-G, CC-EG, and CC-U were more inclined to selectively separate lignin than hemicellulose. The crystalline cellulose II structure was retained after DES pretreatment. Acidic DESs effectively improved the crystallinity of bagasse fiber; the crystallinities for CC-OA and CC-LA pretreatment were 62.26% and 61.65%, respectively. The lignin dissolved in DES was mainly syringyl lignin. The lignin dissolved in CC-U, CC-LA, and CC-OA contained a small amount of guaiacyl lignin.

scholarly journals Biocompatible natural deep eutectic solvent-based extraction and cellulolytic enzyme-mediated transformation of Pueraria mirifica isoflavones: a sustainable approach for increasing health-bioactive constituents

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Fonthip Makkliang ◽  
Boondaree Siriwarin ◽  
Gorawit Yusakul ◽  
Suppalak Phaisan ◽  
Attapon Sakdamas ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Cellulolytic Enzymes ◽  
Cellulolytic Enzyme ◽  
Optimal Conditions ◽  
Bioactive Constituents ◽  
Pueraria Mirifica ◽  
Assisted Extraction ◽  
Natural Deep Eutectic Solvents ◽  
Natural Deep Eutectic Solvent

AbstractThe presence of specific gut microflora limits the biotransformation of Pueraria mirifica isoflavone (PMI) glycosides into absorbable aglycones, thus limiting their health benefits. Cellulolytic enzyme-assisted extraction (CAE) potentially solves this issue; however, solvent extraction requires recovery of the hydrophobic products. Here, we established the simultaneous transformation and extraction of PMIs using cellulolytic enzymes and natural deep eutectic solvents (NADESs). The NADES compositions were optimized to allow the use of NADESs as CAE media, and the extraction parameters were optimized using response surface methodology (RSM). The optimal conditions were 14.7% (v/v) choline chloride:propylene glycol (1:2 mol ratio, ChCl:PG) at 56.1 °C for the cellulolytic enzyme (262 mU/mL) reaction in which daidzin and genistin were extracted and wholly transformed to their aglycones daidzein and genistein. The extraction of PMIs using ChCl:PG is more efficient than that using conventional solvents; additionally, biocompatible ChCl:PG enhances cellulolytic enzyme activity, catalyzing the transformation of PMIs into compounds with higher estrogenicity and absorbability.

Toxico-metabolomics study of a deep eutectic solvent comprising choline chloride and urea suggests in vivo toxicity involving oxidative stress and ammonia stress

2021 ◽  
Vol 23 (3) ◽  
pp. 1300-1311 ◽  
Author(s):  
Dasom Jung ◽  
Jae Back Jung ◽  
Seulgi Kang ◽  
Ke Li ◽  
Inseon Hwang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
In Vivo Toxicity ◽  
Metabolomics Study ◽  
Ammonia Stress

The in vitro and in vivo studies suggest that choline chloride-based deep eutectic solvents may not be considered as pure, safe mixtures even if they consist of safe compounds.

scholarly journals Deep Eutectic Solvents Based Choline Chloride for Enzymatic Biodiesel Production from Degumming Palm Oil

2020 ◽  
Vol 32 (4) ◽  
pp. 733-738 ◽  
Author(s):  
R. Manurung ◽  
Taslim ◽  
A.G.A. Siregar
Keyword(s):  
Palm Oil ◽  
Raw Materials ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Biodiesel Production ◽  
Chloride Salt ◽  
Enzymatic Reactions ◽  
Potential Applications ◽  
Palm Oil Biodiesel

Deep eutectic solvents (DESs) have numerous potential applications as cosolvents. In this study, use of DES as organic solvents for enzymatic biodiesel production from degumming palm oil (DPO) was investigated. Deep eutectic solvent was synthesized using choline chloride salt (ChCl) compounds with glycerol and 1,2-propanediol. Deep eutectic solvent was characterized by viscosity, density, pH and freezing values, which were tested for effectiveness by enzymatic reactions for the production of palm biodiesel with raw materials DPO. Deep eutectic solvent of ChCl and glycerol produced the highest biodiesel yield (98.98%); weight of DES was only 0.5 % of that of the oil. In addition, the use of DES maintained the activity and stability of novozym enzymes, which was assessed as the yield until the 6th usage, which was 95.07 % biodiesel yield compared with the yield without using DES. Hence, using DES, glycerol in enzymatic biodiesel production had high potentiality as an organic solvent for palm oil biodiesel production

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