scholarly journals New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 807 ◽  
Author(s):  
Gabriel Mencia ◽  
Tania Lozano-Cruz ◽  
Mercedes Valiente ◽  
Javier de la Mata ◽  
Jesús Cano ◽  
...  
Keyword(s):  
Self Assembly ◽  
Focal Point ◽  
Water Soluble ◽  
Biological Applications ◽  
Resonance Imaging ◽  
19F Mri ◽  
19F Magnetic Resonance Imaging ◽  
Or Gene ◽  
Supramolecular Aggregation ◽  
Dendritic Structures

The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.

Perfluoro-tert-butanol: a cornerstone for high performance 19F magnetic resonance imaging

2021 ◽  
Author(s):  
Tingjuan Wu ◽  
Anfeng Li ◽  
Kexin Chen ◽  
Xingxing Peng ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Performance ◽  
Imaging Spectroscopy ◽  
Resonance Imaging ◽  
Background Interference ◽  
Tert Butanol ◽  
19F Mri ◽  
Valuable Complement ◽  
19F Magnetic Resonance Imaging

As a valuable complement to its proton-based counterpart (1H MRI/NMR), fluorine-based magnetic resonance imaging/spectroscopy (19F MRI/NMR) provides quantitative images or spectroscopy without background interference, which has become an extensively used...

pH responding reversible supramolecular self-assembly of water-soluble amino-imidazole-armed perylene diimide dye for biological applications

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 2207-2212 ◽  
Author(s):  
Wei Zhang ◽  
Shi-Yu Gan ◽  
Feng-Hua Li ◽  
Dong-Xue Han ◽  
Qi-Xian Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular Structure ◽  
Fluorescence Emission ◽  
Water Soluble ◽  
Perylene Diimide ◽  
Biological Applications ◽  
External Ph ◽  
Amino Imidazole

A water-soluble amino-imidazole-armed perylene diimide dye exhibits reversible supramolecular structure and fluorescence emission conversion upon external pH-stimulation.

scholarly journals Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging

2021 ◽  
Vol 8 (9) ◽  
pp. 121
Author(s):  
Marion Le Gal ◽  
Estelle Renard ◽  
Christelle Simon-Colin ◽  
Benoit Larrat ◽  
Valérie Langlois
Keyword(s):  
Imaging Techniques ◽  
Liquid Core ◽  
Acquisition Time ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Ene Reactions ◽  
Perfluorooctyl Bromide ◽  
19F Mri ◽  
19F Magnetic Resonance Imaging ◽  
Undecenoic Acid

Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, was produced by marine bacteria using coprah oil and undecenoic acid as substrates. PHA-g-(F; PEG) was prepared by two successive controlled thiol-ene reactions from PHAU with firstly three fluorinated thiols having from 3 up to 17 fluorine atoms and secondly with PEG-SH. The resulting PHA-g-(F; PEG)-based PFOB nanocapsules, with a diameter close to 250–300 nm, are shown to be visible in 19F MRI with an acquisition time of 15 min. The results showed that PFOB-nanocapsules based on PHA-g-(F; PEG) have the potential to be used as novel contrast agents for 19F MRI.

scholarly journals Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Huanzhi Hou ◽  
Pengfei Sun ◽  
Quli Fan ◽  
Xiaomei Lu ◽  
Cheng Xue ◽  
...  
Keyword(s):  
Self Assembly ◽  
Laser Scanning ◽  
Morphological Characterization ◽  
Fluorescent Imaging ◽  
Water Soluble ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Biological Applications

Water-soluble nanoparticles (Ir/PGlc-NP, Ir/β-1,3-glucan-NP) based on water-soluble glycopolymers (PGlc),β-1,3-glucan polysaccharide, and conjugated phosphorescent Ir (III) complexes were successfully synthesized by self-assembly. The obtained nanoparticles have good spherical morphological characterization with a mean diameter of 50 nm measured by TEM. Ir/PGlc-NP and Ir/β-1,3-glucan-NP showed the same emission maxima at 565 nm in aqueous solution and both caused effective apoptosis and death of HepG2 and Hela cells after being irradiated at 445 nm for 30 min in vitro. Fluorescence cellular imaging was conducted by confocal laser scanning microscopy (CLSM) using HepG2 cells as the model cell in which the nanoparticles had successfully entered into the cytoplasm with high brightness. Furthermore, after injecting the nanoparticles into live mice in vivo, the real-time fluorescence imaging as well as the nanoparticles distribution in organs at 24 hours after administration indicated that these nanoparticles can serve as fluorescent imaging contrast for further biological applications.

scholarly journals Correction: Spermine-directed supramolecular self-assembly of water-soluble AIE-active tetraphenylethylene: nanobelt, nanosheet, globular and nanotubular structures

2021 ◽  
Vol 45 (5) ◽  
pp. 2830-2830
Author(s):  
Duong Duc La ◽  
Jotiram N. Malegaonkar ◽  
Mohammad Al Kobaisi ◽  
Rajesh S. Bhosale ◽  
Sidhanath V. Bhosale ◽  
...  
Keyword(s):  
Self Assembly ◽  
Water Soluble

Correction for ‘Spermine-directed supramolecular self-assembly of water-soluble AIE-active tetraphenylethylene: nanobelt, nanosheet, globular and nanotubular structures’ by Duong Duc La et al., New J. Chem., 2018, 42, 15379–15386, DOI: 10.1039/C8NJ02636J.

Parameter optimization and calibration of 19F magnetic resonance imaging at 1.5 Tesla

1991 ◽  
Vol 9 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Benzhi Gong ◽  
Michael Gill ◽  
David B. Washburn ◽  
W. Clark Davenport ◽  
Dorothy Adams ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Parameter Optimization ◽  
Resonance Imaging ◽  
19F Magnetic Resonance Imaging

A cationic water-soluble pillar[6]arene: synthesis, host–guest properties, and self-assembly with amphiphilic guests in water

RSC Advances ◽  
2013 ◽  
Vol 3 (46) ◽  
pp. 23953 ◽  
Author(s):  
Yingjie Ma ◽  
Jie Yang ◽  
Jinying Li ◽  
Xiaodong Chi ◽  
Min Xue
Keyword(s):  
Self Assembly ◽  
Water Soluble

Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release

2017 ◽  
Vol 8 (34) ◽  
pp. 5157-5166 ◽  
Author(s):  
A. V. Fuchs ◽  
A. P. Bapat ◽  
G. J. Cowin ◽  
K. J. Thurecht
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hyperbranched Polymer ◽  
Relaxation Times ◽  
Mri Contrast Agent ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
19F Mri ◽  
Magnetic Resonance Imaging Mri

A switchable polymeric 19F magnetic resonance imaging (MRI) contrast agent was synthesised whereby the transverse (T2) relaxation times increased as a therapeutic was released from a hyperbranched polymer (HBP) scaffold.

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