Screening of analgesic and anti-inflammatory active component in Fructus Alpiniae zerumbet based on spectrum-effect relationship and GC-MS

2017 ◽  
Vol 32 (3) ◽  
pp. e4112 ◽  
Author(s):  
Rui-Yao Xiao ◽  
Ling-Jing Wu ◽  
Xiao-Xiao Hong ◽  
Ling Tao ◽  
Peng Luo ◽  
...  
Keyword(s):  
Active Component ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

Identification of anti-inflammatory components in Sinomenii Caulis based on spectrum-effect relationship and chemometric methods

2019 ◽  
Vol 167 ◽  
pp. 38-48 ◽  
Author(s):  
Lan-Jin Wang ◽  
Zheng-Meng Jiang ◽  
Ping-Ting Xiao ◽  
Jian-Bo Sun ◽  
Zhi-Ming Bi ◽  
...  
Keyword(s):  
Chemometric Methods ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

scholarly journals Discovering the Major Antitussive, Expectorant, and Anti-Inflammatory Bioactive Constituents in Tussilago farfara L. Based on the Spectrum–Effect Relationship Combined with Chemometrics

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 620 ◽  
Author(s):  
Liu Yang ◽  
Hai Jiang ◽  
Song Wang ◽  
Ajiao Hou ◽  
Wenjing Man ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Pharmacological Effects ◽  
Least Squares Regression ◽  
Bioactive Constituents ◽  
Flower Bud ◽  
Active Compounds ◽  
Effect Relationship ◽  
Tussilago Farfara ◽  
Anti Inflammatory ◽  
Spectrum Effect

Farfarae Flos (FF) is the dried flower bud of Tussilago farfara L, which has antitussive, expectorant, and anti-inflammatory effects. However, little research on the main active composition of FF has been reported. The purpose of this study is to find the main active compounds responsible for the three pharmacological effects (i.e., antitussive, expectorant, and anti-inflammatory effects) of Farfarae Flos, based on the spectrum–effect relationship combined with chemometrics. First, this study uses the UPLC-QDA method to establish the chromatography fingerprint of Farfarae Flos, which is combined with chemometrics to analyze 18 batches of samples. Then, we study the antitussive, expectorant, and anti-inflammatory effects of Farfarae Flos. Finally, the spectrum–effect relationship between the fingerprint and the three pharmacological effects are studied by grey correlation analysis and partial least squares regression. The results show that four, four, and three main active constituents were found for the antitussive, expectorant, and anti-inflammatory pharmacological effects, respectively. In conclusion, we found the main active compounds corresponding to the main pharmacodynamic effects of Farfarae Flos. To our knowledge, this is the first time that spectrum–effect relationships in FF have been established using both raw and processed samples, which provides an experimental basis for further studies on the pharmacodynamic material basis of Farfarae Flos, as well as providing reference for the comprehensive evaluation of Farfarae Flos quality and the development of substitute resources.

scholarly journals Identification of anti-inflammatory components of raw and steamed Panax notoginseng root by analyses of spectrum-effect relationship

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 17950-17958 ◽  
Author(s):  
Zejun Zhang ◽  
Lijuan Chen ◽  
Xiuming Cui ◽  
Yiming Zhang ◽  
Yupiao Hu ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Effect Relationship ◽  
Anti Inflammatory ◽  
Spectrum Effect

The differentiated components related to the anti-inflammatory effects of raw and steamed Panax notoginseng were uncovered by the analysis of spectrum-effect relationship.

scholarly journals Multivariate Statistical Analysis Uncovers Spectrum–Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Saffron

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Ya You ◽  
Zijin Xu ◽  
Qingrou Zhong ◽  
Lin Zhu ◽  
Susu Lin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Quality Control ◽  
Evaluation Method ◽  
Control Method ◽  
Partial Least Square ◽  
Least Square ◽  
Crocus Sativus ◽  
Effect Relationship ◽  
Spectrum Effect

Crocus sativus L. is commonly used as functional food and medicinal herb in traditional Chinese medicine. In this study, the spectrum–effect relationship was established between HPLC fingerprints and in vitro antioxidant activity of saffron to improve the quality evaluation method of saffron. The fingerprints of 21 batches of saffron collected from different regions were assessed, and the data were further analyzed by chemometric methods, including similarity analysis, hierarchical clustering analysis, principal component analysis, and orthogonal partial least squares discriminant analysis. The spectrum–effect relationship between fingerprints and antioxidant effect of saffron was analyzed by grey relational analysis and partial least square methods to figure out the antioxidant component of saffron. Thirteen common peaks of 21 batches of saffron were included in the analysis, and peak 3 (picrocrocin), peak 7 (crocin I), and peak 10 (crocin II) were identified as the main active components responsible for antioxidant efficacy. Besides, a multi-index quality control method was developed for simultaneous determination of these three antioxidant components in saffron. Taken together, this study provided new strategies for the quality control and the development of new bioactive products of saffron in the future.

scholarly journals Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Zhuo Chen ◽  
Hao Xu
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Immune Cells ◽  
Active Component ◽  
Salvia Miltiorrhiza ◽  
Pleiotropic Effects ◽  
Tanshinone Iia ◽  
Anti Inflammatory ◽  
Cell Signaling Pathways

Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component ofSalvia miltiorrhizaBunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti-inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis research, including immune cells, antigens, cytokines, and cell signaling pathways.

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