scholarly journals Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3815 ◽  
Author(s):  
Suhair Sunoqrot ◽  
Eveen Al-Shalabi ◽  
Lina Hasan Ibrahim ◽  
Hiba Zalloum
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Skin Tone ◽  
Plant Polyphenols ◽  
Transmission Electron ◽  
Ft Ir ◽  
And Function ◽  
First Time

Plant polyphenols have received considerable attention in recent years due to their ability to undergo oxidation-triggered self-polymerization, forming biocompatible versatile coatings and templated nanoparticles (NPs) that can be leveraged for a variety of biomedical applications. Here we show for the first time that untemplated NPs can be conveniently synthesized from the abundant plant polyphenol quercetin (QCT) simply by incubation with an oxidizing agent in a universal organic solvent, followed by self-assembly upon gradual addition of water. The process yielded NPs of around 180–200 nm in size with a range of colors that resembled light to medium-brown skin tones. The NPs were characterized by UV-Vis, FT-IR, and 1H-NMR spectroscopy and by dynamic light scattering and transmission electron microscopy to understand their physicochemical properties. Antioxidant and cell viability assays were also conducted to demonstrate the NPs’ free-radical scavenging activity and biocompatibility, altogether providing valuable insights into the structure and function of this emerging class of nanomaterials to guide future biomedical applications.

scholarly journals Structure and Function of Trypsin-Loaded Fibrinolytic Liposomes

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anna Tanka-Salamon ◽  
Attila Bóta ◽  
András Wacha ◽  
Judith Mihály ◽  
Miklós Lovas ◽  
...  
Keyword(s):  
Freeze Fracture ◽  
Product Concentration ◽  
Plasma Clot ◽  
Dynamic Conditions ◽  
X Ray Scattering ◽  
Transmission Electron ◽  
Ft Ir ◽  
And Function ◽  
Targeted Release ◽  
Fibrinolytic Action

Protease encapsulation and its targeted release in thrombi may contribute to the reduction of haemorrhagic complications of thrombolysis. We aimed to prepare sterically stabilized trypsin-loaded liposomes (SSLT) and characterize their structure and fibrinolytic efficiency. Hydrogenated soybean phosphatidylcholine-basedSSLTwere prepared and their structure was studied by transmission electron microscopy combined with freeze fracture (FF-TEM), Fourier transform infrared spectroscopy (FT-IR), and small-angle X-ray scattering (SAXS). Fibrinolytic activity was examined at 45, 37, or 24°C on fibrin or plasma clots with turbidimetric and permeation-driven lysis assays. Trypsin was shown to be attached to the inner surface of vesicles (SAXS and FF-TEM) close to the lipid hydrophilic/hydrophobic interface (FT-IR). The thermosensitivity ofSSLTwas evidenced by enhanced fibrinolysis at 45°C: time to reduce the maximal turbidity to 20% decreased by 8.6% compared to 37°C and fibrin degradation product concentration in the permeation lysis assay was 2-fold to 5-fold higher than that at 24°C.SSLTexerted its fibrinolytic action on fibrin clots under both static and dynamic conditions, whereas plasma clot dissolution was observed only in the permeation-driven assay. The improved fibrinolytic efficiency ofSSLTunder dynamic conditions suggests that they may serve as a novel therapeutic candidate for dissolution of intravascular thrombi, which are typically exposed to permeation forces.

scholarly journals Synthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives

2019 ◽  
Vol 31 (11) ◽  
pp. 2448-2452
Author(s):  
Somashekara Bhadrachar ◽  
Giriyapura R. Vijayakumar ◽  
Kittappa M. Mahadevan ◽  
Thippeswamy Basavaraja
Keyword(s):  
Molecular Docking ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Docking Study ◽  
Ceric Ammonium Nitrate ◽  
Assay Method ◽  
Molecular Docking Study ◽  
Ft Ir ◽  
Free Radical Scavenging Assay

A series of 1,2,4,5-tetrasubstituted imidazoles (2a-g) were synthesized using 1,2-diketone, 1-naphthaldehyde, substituted aromatic amine and ammonium acetate in the presence of ceric ammonium nitrate as a catalyst. The synthesized compounds were characterized by FT-IR, 1H NMR, Mass spectra and explored for their antioxidant activity by DPPH free radical scavenging assay method. Among the synthesized compounds 2a, 2e and 2f exhibit good antioxidant activities. Molecular docking study was also been performed to know the possible interactions between the synthesized compound and antioxidant receptor 3MNG.

Peripherally substituted soluble nickel phthalocyanines: Synthesis, characterization, aggregation behavior and antioxidant properties

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1478-1485
Author(s):  
Senem Çolak Yazıcı ◽  
Sibel Kahraman ◽  
Salih Z. Yıldız ◽  
Mahmut D. Yılmaz
Keyword(s):  
Sulfonic Acid ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
The Novel ◽  
Diammonium Salt ◽  
Ft Ir ◽  
Radical Scavenging Ability

Tetra-zwitterionic-substituted nickel(II) phthalocyanine derivatives were newly synthesized starting from nonionic 2(3),9(10),16(17),23(24)-tetrakis-[2-([Formula: see text]-((3-dimethylamino)propyl)carbamate)oxyethyl)phthalocyaninato nickel (II). The novel compounds have been characterized by a combination of UV-vis, FT-IR and mass spectroscopies and elemental analysis. The critical micelle concentrations of the prepared compounds were measured, and the antioxidant activities were analyzed with radical scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and with 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). The zwitterionic molecules showed aggregated spectra in the UV-vis region, and they might be good surfactant candidates for the detergent industry with their appropriate critical micelle concentration (CMC) properties in water. The compounds exhibited ABTS radical scavenging activity and thus they have antioxidant activity.

Synthesis, Characterization and Biological Activities of Substituted 1-[Benzothiazol-(1H)-2-yl]-3-phenyl-prop-2-en-1-ones

2019 ◽  
Vol 4 (3) ◽  
pp. 144-146
Author(s):  
C. Anuba ◽  
T.F. Abbs Fen Reji
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Ft Ir ◽  
Standard Solution ◽  
Uv Visible ◽  
Substituted 1 ◽  
Mtt Assays

A series of ortho and para substituted 1-[benzothiazol-(1H)-2-yl]-3-phenyl-prop-2-en-1-one derivatives were synthesized from 2-acetyl benzothiazole and ortho and para-substituted benzaldehye using ethanol as solvent. The synthesized compounds were characterized by UV-visible, FT-IR, 1H NMR and mass spectrometry. Antioxidant activities of synthesized compounds have been evaluated by DPPH free radical scavenging activity using ascorbic acid as standard. The standard solution and 1-[benzothiazol- (1H)-2-yl]-3-phenylprop-2-en-1-ones compounds were prepared with different concentrations. Anticancer activity of 1-[benzothiazol-(1H)-2-yl]-3-phenylprop-2-en-1-one and 1-[benzothiazol-(1H)- 2-yl]-3(4-chlorophenyl)prop-2-en-1-one were assigned by MTT assays.

Synthesis of Polystyrene-B-Poly(Ethylene Oxide)monomethyl Ethermethacrylate Block Copolymers and its Self-Assembly in Aqueous Solution

2011 ◽  
Vol 284-286 ◽  
pp. 769-772
Author(s):  
Qian Qian You ◽  
Pu Yu Zhang
Keyword(s):  
Aqueous Solution ◽  
Molecular Weight ◽  
Block Copolymers ◽  
Self Assembly ◽  
Chain Transfer ◽  
Functional Group ◽  
Transmission Electron ◽  
Reversible Addition ◽  
Ft Ir ◽  
A Chain

The block copolymer of PSt-b-POEOMA with the end of -COOH functional group has been synthesized by reversible addition fragmentation chain-transfer (RAFT) using S,S′-Bis(α,α′-dimethyl-α′′-acetic acid)-trithiocarbonate (BDATC) as a chain transfer agent. The architectures of the copolymers were confirmed by FT-IR and 1HNMR spectra. GPC analysis was used to estimate the molecular weight and the molecular weight distribution of the copolymers. Meanwhile, The nanostructures of the block copolymers PSt-b-POEOMA micelles formed in aqueous solution were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS).

scholarly journals Synthesis of V2O3/C composites with different morphologies by a facile route and phase transition properties of the compounds

2014 ◽  
Vol 32 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Yifu Zhang ◽  
Nannan Wang ◽  
Yuting Huang ◽  
Chi Huang ◽  
Xiao Mei ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Phase Transition ◽  
Hydrothermal Route ◽  
Scanning Calorimetry ◽  
Transmission Electron ◽  
Facile Hydrothermal Route ◽  
Potential Applications ◽  
Subsequent Calcination ◽  
Ft Ir ◽  
First Time

AbstractV2O3 and amorphous carbon composites (V2O3/C composites) with different morphologies (e.g. nanospheres, nanorods and nanosheets) were, for the first time, successfully synthesized by a facile hydrothermal route and subsequent calcination. The as-obtained samples were characterized by X-ray powder diffraction (XRD), energy dispersive spectrometery (EDS), elemental analysis (EA), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The morphology of V2O3/C composites could be easily controlled by varying the reaction time, and, as a result, V2O3/C composites with nanospheres, nanorods and nanosheets were selectively synthesized. Furthermore, the phase transition property of V2O3/C composites was measured by differential scanning calorimetry (DSC), suggesting that V2O3/C composites exhibit the phase transition similar to V2O3, which could expand the potential applications of materials related to V2O3 in the future.

scholarly journals Antibacterial, antioxidant and cytotoxic activities of different fractions of acetone extract from flowers of Dipterocarpus intricatus Dyer (Dipterocarpaceae)

2021 ◽  
Vol 8 (2) ◽  
pp. 273-277
Author(s):  
Hong Thia Le ◽  
Thao Nguyen Luu ◽  
Huynh Mai Thu Nguyen ◽  
Dang HoaiTrang Nguyen ◽  
Pham Tan Quoc Le ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Salmonella Enteritidis ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Acetone Extract ◽  
Cytotoxic Agents ◽  
Diffusion Method ◽  
Cytotoxic Activities ◽  
Ic50 Values ◽  
First Time

This study has shown for the first time the antimicrobial, antioxidant and cytotoxicity of 3 fractions of acetone extract, including hexane, chloroform and ethyl acetate from flowers of Dipterocarpus intricatus. Antibacterial test using disc diffusion method showed that the chloroform and ethyl acetate fractions inhibited the growth of all the tested bacteria, including Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, Salmonella typhimurium, Bacillus cereus and Staphylococcus aureus while the hexane fraction showed the antibacterial activity against B. cereus and S. enteritidis. Antioxidant activity and cancer cell resistance of those extracts were conducted using DPPH and MTT methods respectively. As a result, the DPPH radical scavenging activity of the hexane, chloroform and ethyl acetate fractions were determined with the IC50 values of 0.508, 0.22 and 0.075 mg/mL respectively while the cytotoxicity to HepG2 cell line of those fractions was 163.3 ppm, 106.7 ppm and 459.3 ppm. These results suggested the potential application of these fractions isolated from D. intricatus flowers as the natural antimicrobial, antioxidant and cytotoxic agents for medicine.

scholarly journals Control over size, shape, and photonics of self-assembled organic nanocrystals

2020 ◽  
Author(s):  
Chen Shahar ◽  
Yaron Tidhar ◽  
Yunmin Jung ◽  
Haim Weissman ◽  
Sidney R Cohen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Transient Absorption ◽  
Aqueous Media ◽  
Excitation Energy Transfer ◽  
Building Blocks ◽  
Transient Absorption Spectroscopy ◽  
Organic Nanocrystals ◽  
Femtosecond Transient Absorption ◽  
Transmission Electron ◽  
And Function

Facile fabrication of free-floating organic nanocrystals (ONCs) was achieved via kinetically controlled self-assembly of simple amphiphilic perylene diimide building blocks in aqueous media. The ONCs have a thin rectangular shape, with the aspect ratio that is controlled via organic co-solvent (THF) content. The nanocrystals were characterized in solution by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS); the ONCs retain their structure upon drying as was evidenced by TEM and AFM. Photophysical studies, including femtosecond transient absorption spectroscopy, revealed a distinct influence of the ONC morphology on their photonic properties (excitation energy transfer was observed only in the high aspect ONCs). Convenient control over structure and function of organic nanocrystals can enhance their utility in new and developed technologies.

Synthesis, admetSAR predictions, DPPH radical scavenging activity and potent anti-mycobacterial studies of hydrazones of substituted 4-(anilinomethyl)benzohydrazides (Part 2)

2020 ◽  
Vol 16 ◽  
Author(s):  
Vijay J. Desale ◽  
Suraj N. Mali ◽  
Bapu R. Thorat ◽  
Ramesh S. Yamgar
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Spectroscopic Characterization ◽  
Common Infectious Disease ◽  
In Silico Admet ◽  
Ft Ir ◽  
Mycobacteria Tuberculosis ◽  
Dpph Radical Scavenging

Background: For the past several decades, we are remarking presence of the tuberculosis (TB) as the most common infectious disease leading mortality.and antimicrobial, etc. Objective: Hydrazone containing azometine group (-NHN=CH-) compounds has been reported for broad range of bioactivities such as antiplatelet, analgesic, antiinflammatory, anticonvulsant, antidepressant, antimalarial, vasodilator , antiviral and antimicrobial, etc. Method: For synthesis of our compounds (4a-4d) and (6a-6e), we have treated aromatic amines with methyl terephthalaldehydate in methanol giving us Schiff’s bases followed by reductive amination and further treatment with hydrazine hydrate to give acid hydrazides (4a-4d). These acid hydrazides were then treated with different aromatic aldehydes to yield hydrazones (6a-6d). All our synthesized compounds were subjected to FT-IR, NMR, and UV spectroscopic characterization. Results: Compounds (4a-4d) and (6a-6e) were found to have highly potent activity against Mycobacteria tuberculosis (Vaccine strain, H37 RV strains): ATCC No- 27294 (MIC:1.6-6.25 μg/mL) than standard anti-TB drugs. Our compounds exhibited good radical scavenging potentials(0-69.2%) as checked from DPPH protocol. All compounds also demonstrated good in-silico ADMET results. Conclusion: Our current study revealed promising in-vitro antituberculosis and antioxidant profiles of hydrazidehydrazone analogues.

Superoxide Anion Biosensor Based on Bionic-Enzyme Hyperbranched Polyester Particles

2018 ◽  
Vol 71 (3) ◽  
pp. 119
Author(s):  
Yanlian Niu ◽  
Sisheng Hu ◽  
Qian Zhou ◽  
Yang Liu ◽  
Yuhong Liu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Hyperbranched Polyester ◽  
Manganese Phosphate ◽  
Transmission Electron ◽  
O2 Concentration ◽  
Ft Ir ◽  
Novel Method ◽  
Assembly Technology ◽  
Ft Ir Spectroscopy ◽  
Hyperbranched Structure

Self-assembly techniques have been demonstrated to be a useful approach to developing new functional nanomaterials. In this study, a novel method to fabricate a manganese phosphate self-assembly monolayer (SAM) on a hyperbranched polyester (HBPE-OH) nanoparticle surface is described. First, the second-generation aliphatic HBPE-OH was carboxy-terminated, phosphorylated, and then ionized with manganese by a three-step modification process. The final product of HBPE-AMPA-Mn2+ particles was obtained and characterised by FT-IR spectroscopy, 1H NMR spectroscopy, transmission electron microscopy (TEM), Zeta potential, and energy dispersive spectroscopy (EDS). Moreover, the HBPE-AMPA-Mn2+ particles were used to construct a novel biosensor for detection of superoxide anions (O2•−) released from HeLa cells. Results showed that the response currents of this biosensor were proportional to the O2•− concentration ranging from 0.79 to 16.6 μM, and provided an extremely low detection limit of 0.026 μM (S/N = 3). The results indicate that the particle-decorated electrode surface, which involved a hyperbranched structure and a surface self-assembly technology, proposed here will offer the ideal catalytic system for electrochemical enzymatic sensors.

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