scholarly journals Green Approach Extraction of Perezone from the Roots of Acourtia platyphilla (A. Grey): A Comparison of Four Activating Modes and Supercritical Carbon Dioxide

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3035 ◽  
Author(s):  
Escobedo-González ◽  
Cabañas ◽  
González ◽  
Sánchez ◽  
Saavedra-Leos ◽  
...  

Perezone, a sesquiterpene quinone, is a very important molecule due to its pharmacological activities in addition to the fact that it is considered to be the first secondary metabolite isolated in the new world (America–Mexico, 1852). This study aims to offer a green comparative study about the extraction of the target molecule from the roots of the vegetable specimen Acourtia platyphilla (A. Grey). The study was performed comparing five different modes of extraction: supercritical CO2, electromagnetic infrared and microwave irradiations, mechanical-wave ultrasound versus typical mantle heating procedure. An exhaustive comparative-discussion of the obtained results is provided. It is worth noting that the corresponding quantifications were established using 1H NMR, correlating appropriately the integrals of the vinylic proton H-6 of perezone with the aromatic singlet of p-dinitrobenzene employed as an internal reference. It is also important to highlight that the four presented procedures are novel modes to extract perezone. Finally, a complementary study about the solubility of the target sesquiterpene quinone related to the use of supercritical CO2 is also reported.

2020 ◽  
Vol 8 (4) ◽  
pp. 570
Author(s):  
Jaqueline Hoscheid ◽  
Joice Karina Otenio ◽  
Emerson Luiz Botelho Lourenço ◽  
Elissandro Jair Klein ◽  
Camila Da Silva ◽  
...  

Cecropia pachystachya Trécul is popularly known in Brazil as embaúva or embaúba. Pharmacological activities were reported in extant studies including the development of anxiolytic, antidepressant, hypoglycemic, antioxidant, cardiotonic, sedative, anti-inflammatory, antimicrobial and leishmanicidal properties for aqueous and alcoholic extracts prepared by infusion or maceration of C. pachystachya leaves. However, there is a paucity of studies examining extracts of leaves of C. pachystachya obtained by supercritical fluid technology. This study evaluated the extraction of Cecropia pachystachya oil using supercritical carbon dioxide (CO2). Extractions were performed at 35 °C, 45 °C, and 55 °C and 14 MPa, 17 MPa, and 20 MPa. The extraction yield, characteristics of the oil, antioxidant and antibacterial potentials were evaluated. The highest extraction yield obtained from C. pachystachya leaves was 1.48% using supercritical CO2 at 55 °C and 20 MPa. The main identified compounds include terpenoids (ursolic and pomolic acids, squalene and β-sitosterol). The most promising results for antibacterial activity relative to Staphylococcus aureus and antioxidant potentials were observed on the extract obtained at 55 °C and 14 MPa. The mathematical Sovová model satisfactorily represented the experimental data.


2021 ◽  
Vol 323 ◽  
pp. 124633
Author(s):  
Jung-Hun Kim ◽  
Sungyup Jung ◽  
Kun-Yi Andrew Lin ◽  
Jörg Rinklebe ◽  
Eilhann E. Kwon

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Vasanop Vachiramon ◽  
Pattarin Anusaksathien ◽  
Silada Kanokrungsee ◽  
Kumutnart Chanprapaph

Objective. Keratosis pilaris (KP) is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2) laser for the treatment of KP.Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study was conducted on adult patients with KP. A single session of fractional CO2laser was performed to one side of arm whereas the contralateral side served as control. Patients were scheduled for follow-up at 4 and 12 weeks after treatment. Clinical improvement was graded subjectively by blinded dermatologists. Patients rated treatment satisfaction at the end of the study.Results. Twenty patients completed the study. All patients stated that the laser treatment improved KP lesions. At 12-week follow-up, 30% of lesions on the laser-treated side had moderate to good improvement according to physicians’ global assessment (p=0.02). Keratotic papules and hyperpigmentation appeared to respond better than the erythematous component. Four patients with Fitzpatrick skin type V developed transient pigmentary alteration.Conclusions. Fractional CO2laser treatment may be offered to patients with KP. Dark-skinned patients should be treated with special caution.


1992 ◽  
Vol 96 (3) ◽  
pp. 2077-2084 ◽  
Author(s):  
Thanh N. Truong ◽  
John J. Tanner ◽  
Piotr Bala ◽  
J. Andrew McCammon ◽  
Donald J. Kouri ◽  
...  

2018 ◽  
Vol 112 (1) ◽  
pp. 494-498 ◽  
Author(s):  
John Paul Benante ◽  
James Fox ◽  
Kendra Lawrence ◽  
Thanyalak Fansiri ◽  
Arissara Pongsiri ◽  
...  

2010 ◽  
Vol 11 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Shuang Niu ◽  
Zenghui Xu ◽  
Yudan Fang ◽  
Liyun Zhang ◽  
Yingjie Yang ◽  
...  

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