scholarly journals Ionic Liquid-Based Ultrasonic-Assisted Extraction to Analyze Seven Compounds in Psoralea Fructus Coupled with HPLC

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1699 ◽  
Author(s):  
Mengjun Shi ◽  
Juanjuan Zhang ◽  
Cunyu Liu ◽  
Yiping Cui ◽  
Changqin Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Extraction Yield ◽  
Environmentally Benign ◽  
Clinical Effects ◽  
Ultrasonic Power ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid

Psoralea Fructus is widely used in traditional Chinese medicine (TCM), and the content of psoralen, isopsoralen, neobavaisoflavone, bavachin, psoralidin, isobavachalcone, and bavachinin A is the main quality control index of Psoralea Fructus because of its clinical effects. Thus, a fast and environmentally-benign extraction method of seven compounds in Psoralea Fructus is necessary. In this work, an ionic liquid-based ultrasonic-assisted method (ILUAE) for the extraction of seven compounds from Psoralea Fructus was proposed. Several ILs of different types and parameters, including the concentration of ILs, concentration of ethanol (EtOH), solid–liquid ratio, particle size, ultrasonic time, centrifugal speed, and ultrasonic power, were optimized by the Placket–Burman (PB) design and Box–Behnken response surface analysis. Under this optimal condition, the total extraction yield of the seven compounds in Psoralea Fructus was 18.90 mg/g, and significantly greater than the conventional 75% EtOH solvent extraction.

scholarly journals Ultrasonic-Assisted Extraction of Procyanidins Using Ionic Liquid Solution fromLarix gmeliniiBark

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaowei Sun ◽  
Zhimin Jin ◽  
Lei Yang ◽  
Jingwei Hao ◽  
Yuangang Zu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Extraction Efficiency ◽  
Liquid Solution ◽  
Extraction Process ◽  
Ultrasonic Power ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

An ionic liquid-based ultrasonic-assisted extraction method has been developed for the effective extraction of procyanidins fromLarix gmeliniibark. So as to evaluate the performance of ionic liquids in ultrasonic-assisted extraction process, the effects caused by changes in the anion and the alkyl chain length of the cation on the extraction efficiency were investigated in this paper. The results indicated that the characteristics of anions had remarkable effects on the extraction efficiency of procyanidins, and 1-butyl-3-methylimidazolium bromide ([Bmim]Br) aqueous solution was the best among the investigated ionic liquids. The optimum conditions for the extraction were as follows: [Bmim]Br concentration 1.25 M, soak time 3 h, solid-liquid ratio 1 : 10, ultrasonic power 150 W, and ultrasonic time 30 min. This work not only introduces a simple, green, and highly efficient sample preparation method for extraction of procyanidins fromL. gmeliniibark, but also reveals the tremendous application potential of ionic liquids.

scholarly journals A Study of the Ionic Liquid-Based Ultrasonic-Assisted Extraction of Isoliquiritigenin from Glycyrrhiza uralensis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jingwei Hao ◽  
Jiahui Liu ◽  
Lei Zhang ◽  
Yunrong Jing ◽  
Yubin Ji
Keyword(s):  
Ionic Liquid ◽  
Extraction Procedure ◽  
Extraction Yield ◽  
Glycyrrhiza Uralensis ◽  
Extraction Temperature ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
The Times ◽  
Solid Liquid

We successfully extracted isoliquiritigenin from Glycyrrhiza uralensis through the utilization of an ionic liquid-based ultrasonic-assisted extraction (ILUAE) approach. Briefly, we utilized the solution of 1-butyl-3-methylimidazolium bromide ([BMIM]Br) as solvent and optimized key ILUAE parameters such as solid-liquid ratios, concentrations of ionic liquids, and the times of ultrasonication. Based on a single-factor experiment, we utilized the response surface method (RSM) approach to optimize the extraction procedure. The approach revealed that the optimal energy consumption time was 120 min, with the ultrasonic extraction temperature of 60°C. Using these optimized parameters together with the solid-liquid ratio (dried G. uralensis powder: [BMIM]Br of 0.3 mol/L) of 1 : 16.163 and the [BMIM]Br of 0.3 mol/L, we achieved a 0.665 mg/g extraction yield. Overall, these findings thus indicate that we were able to effectively use ILUAE as an efficient approach to reliably extract isoliquiritigenin in a reproducible and environmentally friendly manner.

scholarly journals Application of Ionic Liquid-Based Ultrasonic-Assisted Extraction of Flavonoids from Bamboo Leaves

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2309 ◽  
Author(s):  
Liling Wang ◽  
Minge Bai ◽  
Yuchuan Qin ◽  
Bentong Liu ◽  
Yanbin Wang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Large Scale ◽  
Ultrasonic Power ◽  
Solid Ratio ◽  
Bamboo Leaves ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

Ionic liquids (ILs), known as environmentally benign “green” solvents, were developed as an optimal solvent for the green extraction and separation field. In this paper, an ionic liquid-based ultrasonic-assisted extraction (IL-UAE) of flavonoids (FVs) from bamboo leaves of Phyllostachys heterocycla was developed for the first time. First, 1-butyl-3-methylimidazolium bromide ([Bmim] Br), with the best extraction efficiency, was selected from fifteen ionic liquids with diverse structure, like carbon chains or anions. Then, the influencing parameters of ionic liquid (IL) concentration, liquid-solid ratio, ultrasonic time, and ultrasonic power, were investigated by single factor tests, and further optimized using response surface methodology (RSM). In the optimization experiment, the best conditions were 1.5 mol/L [BMIM]Br aqueous solution, liquid-solid ratio 41 mL/g, ultrasonic time 90 min, and ultrasonic power 300 W. Furthermore, the microstructures of bamboo leaves and the recovery of FVs and [BMIM]Br were also studied. Therefore, this simple, green and effective IL-UAE method has potentiality for the extraction of FVs from bamboo leaves for the large-scale operations.

scholarly journals Efficient Extraction of Anti-Inflammatory Active Ingredients from Schefflera octophylla Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2942 ◽  
Author(s):  
Xuqiang Liu ◽  
Yun Niu ◽  
Jieqing Liu ◽  
Mengjun Shi ◽  
Ruian Xu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Extraction Yield ◽  
Extraction Rate ◽  
Optimal Conditions ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Efficient Extraction ◽  
Ultrasonic Assisted Extraction ◽  
Anti Inflammatory ◽  
Solid Liquid

Schefflera octophylla (Lour.) Harms, a kind of traditional Chinese medicine (TCM), is commonly used for anti-inflammatory, analgesic, rheumatism, fever, and hemostasis therapy. In our previous studies, two major triterpenoids were isolated and identified from leaves of S. octophylla, and evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells; both of them displayed significant anti-inflammatory activities at their noncytotoxic concentrations. Therefore, it is very useful to establish an efficient and green extraction method to isolated the two major triterpenoids from leaves of S. octophylla. In this paper, ionic liquid based ultrasonic-assisted extraction (ILUAE) was successfully applied to extract the two major triterpenoids from leaves of S. octophylla. Four single factors (ionic liquids (ILs) concentration, solid–liquid ratio, centrifugal speed, mesh number), with a greater impact on extraction rate, were selected from a variety of influencing factors, and the optimal conditions were obtained by Box–Behnken response surface methodology (RSM). Under optimal conditions, the total extraction yield and extraction rate of two triterpenoids were 288.03 mg/g and 28.80%, respectively, which was 6.80% higher than that of 70% Ethanol (220 mg/g and 22%, respectively).

scholarly journals Optimization of Ultrasonic-Assisted Extraction, Characterization, and Antioxidant Activities of Polysaccharides From Sojae Semen Praeparatum

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110206
Author(s):  
Yongshuai Jing ◽  
Ruijuan Zhang ◽  
Lan Li ◽  
Danshen Zhang ◽  
Yu Liu ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Deae Cellulose ◽  
Chemical Compositions ◽  
Hydroxyl Groups ◽  
Ultrasonic Frequency ◽  
Ultrasonic Power ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

In this study, response surface methodology (RSM) was used to optimize the ultrasonic-assisted extraction parameters of Sojae Semen Praeparatum polysaccharides (SSPP-80), the optimum conditions were determined as follows: ultrasonic frequency of 100 W, ultrasonic power of 80 Hz, ultrasonic temperature of 52℃, ultrasonic time of 23 minutes, and liquid to raw material ratio of 40 mL/g. Based on these conditions, polysaccharides extraction rate was 7.72% ± 0.26%. Then, 2 novel polysaccharides (SSPP-80‐1, SSPP-80‐2) were isolated from SSPP by DEAE-cellulose 52 chromatography. The chemical compositions, physicochemical properties, and structure of SSPPs were investigated by simultaneous thermal analyzer (TGA), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FI-IR), and high-performance liquid chromatography (HPLC). The results showed that SSPP-80 and 2 fractions were mainly composed of mannose (Man), glucose (Glc), galactose (Gal), xylose (Xyl), and arabinose (Ara). In addition, the antioxidant activities were evaluated against the DPPH and hydroxyl radical in vitro, the IC50 of SSPP-80, SSPP-80‐1 and SSPP-80‐2 against DPPH free radical were 4.407, 8.267, and 5.204 mg/mL, respectively, whereas the IC50values for removing hydroxyl groups were 5.318, 3.516, and 4.016 mg/mL, respectively. It demonstrated that SSPP-80 and 2 fractions had certain antioxidant activity. Theoretical basis for use of Sojae Semen Praeparatum polysaccharides was provided by this study.

Optimization of Ultrasonic-Assisted Extraction of Total Saponins from Ophiopholis mirabilis Using Response Surface Methodology

2013 ◽  
Vol 781-784 ◽  
pp. 687-693
Author(s):  
Zhi Yang Shao ◽  
Jin Xia Fu ◽  
Yan Xia Qi ◽  
Qian Cheng Zhao ◽  
Zhi Bo Li
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Water Bath ◽  
Ultrasonic Power ◽  
Extraction Technology ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

Ultrasonic-Assisted extraction (UAE) was applied for saponins extraction from Ophiopholis mirabilis and response surface methodology (RSM) was used to optimize the extraction technology. A first set of experiments were designed to optimize water bath temperature, ethanol concentration, the ratio of liquid to solid, ultrasonic time (min) and ultrasonic power (W) as the main variables affecting the extraction effect. A Box-Behnken design consisting of 15 experimental runs was then applied and a second-order polynomial model was used to explain the interactions between the main factors and the yield of saponins. The developed mathematical model was found to fit well with the experimental data and the optimized conditions were ultrasonic pretreatment time 30.9 min, ethanol concentration 64%, liquid /solid ratio 35:1, ultrasonic power 300W and water bath 70°C. Corresponding saponins content was 0.574%.

scholarly journals Study on the Extraction of Polyphenols from Blueberry Leaves and their antioxidant properties

2021 ◽  
Vol 251 ◽  
pp. 02059
Author(s):  
Fenghong Liu ◽  
Xianhao Cheng ◽  
Wenguang Liu ◽  
Jing Miu ◽  
Jiahui Wang ◽  
...  
Keyword(s):  
Ethanol Concentration ◽  
Orthogonal Experiment ◽  
Antioxidant Properties ◽  
High Yield ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid ◽  
Blueberry Leaves

Blueberry leaf as materials, ethanol ultrasonic assisted extraction of blueberry polyphenols, ethanol concentration and solid-liquid ratio on blueberry ultrasonic time leaves influence the yield of polyphenols were researched, and the orthogonal experiment to optimize the ethanol ultrasonic assisted extraction technological conditions of blueberry leaf polyphenol polyphenols was used. The results showed that the optimal extraction conditions of polyphenols from blueberry leaves were as follows, 9.06% with 4min ultrasonic time, 80% ethanol concentration and 1:45 (g/mL) ratio. Ultrasonic assisted extraction is a convenient and high yield method, which is suitable for the extraction of polyphenols from blueberry leaves.

scholarly journals Green and Efficient Extraction of Resveratrol from Peanut Roots Using Deep Eutectic Solvents

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jingnan Chen ◽  
Xingxing Jiang ◽  
Guolong Yang ◽  
Yanlan Bi ◽  
Wei Liu
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Box Behnken Design ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Efficient Extraction ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid ◽  
Total Extraction

Deep eutectic solvents (DESs), a new group of ecofriendly solvent combined with the ultrasonic-assisted extraction (UAE) technique, were first successfully used for extraction of resveratrol from peanut roots. Resveratrol in the extract was analyzed and quantified using a HPLC-UV method. A series of DESs consisting of choline chloride (ChCl) and 1,4-butanediol, citric acid, and ethylene glycol were formulated, finding ChCl/1,4-butanediol was a most proper extraction system. The optimal extraction parameters were obtained using a Box–Behnken design (BBD) test combined with response surface methodology as follows: 40% of water in ChCl/1,4-butanediol (1/3, g/g) at 55°C for 40 min and solid/liquid ratio of 1:30 g/mL. The total extraction content and extraction yield of resveratrol from peanut roots could reach 38.91 mg/kg and 88.19%, respectively, under such optimal conditions. The present study will provide a typical example for using DESs to extract natural bioactive compounds from plants.

Optimization for the Process of Chlorophyll a Extraction by Orthogonal Method

2014 ◽  
Vol 1051 ◽  
pp. 423-427
Author(s):  
Jun Sen Wu ◽  
Chen Chen Liu ◽  
Bing Li ◽  
Xiu Zhi Wan
Keyword(s):  
Chlorophyll A ◽  
Orthogonal Experiment ◽  
Ultrasonic Power ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Extraction Agent ◽  
Optimum Extraction ◽  
Single Factor Experiment

The 90% acetone as extraction agent used in order to obtain the ultrasonic assisted extraction conditions of chlorophyll a. The ultrasonic power, ultrasonic time, centrifugation time and rotational speed as the four study factors and the chlorophyll a concentration as the target, here, the L9(34) orthogonal table of orthogonal experiment design are used in order to determine the optimum extraction contractions, basing on the single factor experiment. The experimental results shows the algae containing water can get better extraction effect, after ultrasonic 30 minutes in 225W and 6000r/min speed centrifugal 9 minutes and then mixing, repeat ultrasound centrifugation steps.

Comparative Evaluation of Total Flavonoid Contents in Different Parts of Ficus microcarpa

2012 ◽  
Vol 560-561 ◽  
pp. 423-427
Author(s):  
Qiang Lin ◽  
Hao Yue Du ◽  
You Bin Liu ◽  
Yu Kai Chen ◽  
Jing Xu
Keyword(s):  
Extraction Yield ◽  
Total Flavonoid ◽  
Extraction Temperature ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ficus Microcarpa ◽  
Ultrasonic Assisted Extraction ◽  
Pharmaceutical Properties ◽  
Solid Liquid ◽  
Different Parts

This study was designed to comparative evaluate total flavonoid contents (TFC) in leaf, aerial root, twig, root and bark parts of Ficus microcarpa L.f. (Moraceace). Ultrasonic-assisted extraction was adopted using benign solvent: ethanol and water to determine the extraction efficiency under the condition of ethanol concentration 40%, solid/liquid ratio of 1:25, extraction time 35 min and extraction temperature at 60 °C. According to the experimental results, the TFC values varied considerably and the extraction yield of 2.67±0.02%, 3.70±0.043%, 2.99±0.04%, 6.56±0.83% and 4.26±0.18% were obtained from different parts, respectively. The root part was characterized as containing a high amount of flavonoids, which might be the active compounds responsible for the pharmaceutical properties of the plant. The study offers theoretic basis for further utilization of the traditional folk herb F. microcarpa.

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