scholarly journals The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1509 ◽  
Author(s):  
Branislav Kura ◽  
Mihir Parikh ◽  
Jan Slezak ◽  
Grant N. Pierce
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Positive Impact ◽  
Biologically Active ◽  
Food Components ◽  
Important Field ◽  
Bioactive Food Components ◽  
Underlying Mechanisms ◽  
Heart Physiology ◽  
The Impact

Food quality and nutritional habits strongly influence human health status. Extensive research has been conducted to confirm that foods rich in biologically active nutrients have a positive impact on the onset and development of different pathological processes, including cardiovascular diseases. However, the underlying mechanisms by which dietary compounds regulate cardiovascular function have not yet been fully clarified. A growing number of studies confirm that bioactive food components modulate various signaling pathways which are involved in heart physiology and pathology. Recent evidence indicates that microRNAs (miRNAs), small single-stranded RNA chains with a powerful ability to influence protein expression in the whole organism, have a significant role in the regulation of cardiovascular-related pathways. This review summarizes recent studies dealing with the impact of some biologically active nutrients like polyunsaturated fatty acids (PUFAs), vitamins E and D, dietary fiber, or selenium on the expression of many miRNAs, which are connected with cardiovascular diseases. Current research indicates that the expression levels of many cardiovascular-related miRNAs like miRNA-21, -30 family, -34, -155, or -199 can be altered by foods and dietary supplements in various animal and human disease models. Understanding the dietary modulation of miRNAs represents, therefore, an important field for further research. The acquired knowledge may be used in personalized nutritional prevention of cardiovascular disease or the treatment of cardiovascular disorders.

scholarly journals The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression

2021 ◽  
Author(s):  
Wittaya Chaiwangyen
Keyword(s):  
Messenger Rna ◽  
Positive Impact ◽  
Biologically Active ◽  
Transcriptional Gene Silencing ◽  
Cellular Mirnas ◽  
Rna Molecules ◽  
Post Transcriptional Gene Silencing ◽  
Molecular Machinery ◽  
Different Origins ◽  
The Impact

MicroRNAs (miRNAs) are a class of non-coding endogenous RNA molecules that are involved in post-transcriptional gene silencing via binding to their target messenger RNA, leading to mRNA degradation or translational repression. MicroRNAs can be modulated by several factors including hormones, transcription factors, and dietary compounds. These biologically active compounds have positive impact on the progression of human pathology including non-communicable diseases, which indicating that administration of diet may have potential as therapeutic agents in modulating the risk of chronic diseases. Interestingly, evidence emerging in recent years suggests that dietary miRNAs can be absorbed in human circulation, modulated human gene expression and biological functions. The exploitation of the miRNA functioning within different origins, cellular miRNAs and dietary miRNAs will help us to understand the molecular machinery as well as the regulatory mechanisms involved in fundamentally important biological processes. Therefore, this knowledge may be applied of natural bioactive compounds in preventive or therapeutic approaches.

scholarly journals Sex–Gender Disparities in Cardiovascular Diseases: The Effects of Estrogen on eNOS, Lipid Profile, and NFATs During Catecholamine Stress

2021 ◽  
Vol 8 ◽  
Author(s):  
Marie Louise Ndzie Noah ◽  
Gabriel Komla Adzika ◽  
Richard Mprah ◽  
Adebayo Oluwafemi Adekunle ◽  
Joseph Adu-Amankwaah ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Physiological State ◽  
Premenopausal Women ◽  
Gender Disparities ◽  
Activated T Cells ◽  
Pathological Cardiac Hypertrophy ◽  
Menopausal Women ◽  
Underlying Mechanisms ◽  
Post Menopausal ◽  
The Impact

Cardiovascular diseases (CVDs) characterized by sex–gender differences remain a leading cause of death globally. Hence, it is imperative to understand the underlying mechanisms of CVDs pathogenesis and the possible factors influencing the sex–gender disparities in clinical demographics. Attempts to elucidate the underlying mechanisms over the recent decades have suggested the mechanistic roles of estrogen in modulating cardioprotective and immunoregulatory effect as a factor for the observed differences in the incidence of CVDs among premenopausal and post-menopausal women and men. This review from a pathomechanical perspective aims at illustrating the roles of estrogen (E2) in the modulation of stimuli signaling in the heart during chronic catecholamine stress (CCS). The probable mechanism employed by E2 to decrease the incidence of hypertension, coronary heart disease, and pathological cardiac hypertrophy in premenopausal women are discussed. Initially, signaling via estrogen receptors and β-adrenergic receptors (βARs) during physiological state and CCS were summarized. By reconciling the impact of estrogen deficiency and hyperstimulation of βARs, the discussions were centered on their implications in disruption of nitric oxide synthesis, dysregulation of lipid profiles, and upregulation of nuclear factor of activated T cells, which induces the aforementioned CVDs, respectively. Finally, updates on E2 therapies for maintaining cardiac health during menopause and suggestions for the advancement treatments were highlighted.

Abstract P321: Pregnancy Loss is Associated With Subclinical Cardiovascular Disease in Mexican Women

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Sandra A Hartasanchez ◽  
Mario Flores ◽  
Adriana Monge ◽  
Elsa Yunes ◽  
Carlos Cantu-Brito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Pregnancy Loss ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Underlying Mechanisms ◽  
The Impact

Introduction: Cardiovascular disease (CVD) in women often develops in the absence of conventional risk factors. Prenatal loss, a common pregnancy outcome, may result in physiologic changes that could affect future risk of myocardial infarction. Little is known about the impact of pregnancy loss on early markers of CVD risk. Hypothesis: Pregnancy loss affects carotid artery intima-media thickness (CIMT). Methods: We conducted a cross-sectional analysis among 1,769 disease-free women from the Mexican Teachers’ Cohort who had been pregnant to evaluate the relation between pregnancy loss and CIMT. In 2008 participants answered a baseline questionnaire on reproductive history, risk factors for chronic disease and medical conditions that was updated in 2011. We defined pregnancy loss as abortion and/or stillbirth. Between 2012 and 2016, CIMT was measured by trained neurologists using ultrasound in three clinical sites. We log-transformed CIMT and defined carotid atherosclerosis as CIMT ≥0.8mm or plaque. We used multivariable linear and logistic regression models to assess the relation between pregnancy loss, CIMT and carotid atherosclerosis. Results: Mean age of participants was 49.8 (SD ± 5.1) years. The prevalence of pregnancy loss was 22% (394 of 1769) , while we observed carotid atherosclerosis in 23% (405 of 1769) of participants. Comparing participants who reported a pregnancy loss to those who did not, the multivariable-adjusted odds ratio for carotid atherosclerosis was 1.52 (95% CI 1.12, 2.06). Women who experienced a stillbirth had 2.32 higher odds (95% CI 1.03, 5.21) of carotid atherosclerosis than those who did not. Mean CIMT appeared to be higher in women who reported a pregnancy loss relative to those who did not, however, in multivariable analyses, pregnancy loss and stillbirth were not significantly associated with CIMT. Conclusions: Abortion and stillbirth may be associated with a higher risk of CVD. Additional investigation on potential underlying mechanisms for this association is required.

Adverse events in cardiovascular disease patients taking clopidogrel: impact of CYP2C19 genotype polymorphisms

2020 ◽  
Author(s):  
Zegan Liu ◽  
Qian Hu ◽  
Li Tang ◽  
Junlong Ma ◽  
Jiangfan Cai ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Adverse Events ◽  
Antiplatelet Therapy ◽  
Onset Time ◽  
Cyp2c19 Genotype ◽  
Significant Difference ◽  
Main Factors ◽  
The Impact ◽  
Cyp2c19 Polymorphisms

Abstract Background: Clopidogrel combined with aspirin in antiplatelet therapy is the first-line clinical regimen for cardiovascular diseases. The CYP2C19 gene influences the absorption and metabolism of clopidogrel and its polymorphisms affect antiplatelet therapy drug efficacy, which may lead to adverse events including stent thrombosis and haemorrhage. The main objective of this study was to explore the impact of CYP2C19 polymorphisms on adverse events in cardiovascular disease patients.Methods:We recruited 350 patients taking clopidogrel and performed CYP2C19 genotype testing. Adverse event information was collected through telephone follow-up. According to CYP2C19 genotype results, patients were divided into three groups: poor metabolism (PM) group, extensive metabolism (EM) group and intermediate metabolism (IM) group. The number of adverse events was compared between the three groups using the chi-squared test and the onset time of adverse events was analysed using the log-rank test. The main factors affecting adverse events were analysed using binary logistic analysis.Results: In total, 326 patients were included in the analysis: 143 patients were in the EM group, 129 patients were in the IM group and 54 patients were in the PM group. In this cohort, 127 adverse events were noted, which occurred in 88 patients. There was no significant difference in the occurrence of adverse events between the EM group and PM group (P=0.185). The median survival times of adverse events in the EM, IM and PM groups were 112 days, 137.5 days and 169 days, respectively, with no significant differences between the three groups (P=0.8713).Conclusion:We found that CYP2C19 polymorphisms were not necessarily associated with adverse events in patients with cardiovascular diseases taking clopidogrel. Rather, the main factors influencing the occurrence of adverse events were concomitant diseases such as hypertension, diabetes and hyperlipidaemia.

scholarly journals Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

2020 ◽  
Vol 7 ◽  
Author(s):  
Barbara J. Stillwater ◽  
Ashleigh C. Bull ◽  
Donato F. Romagnolo ◽  
Leigh A. Neumayer ◽  
Micah G. Donovan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Narrative Review ◽  
Food Components ◽  
Bioactive Food Components ◽  
The Impact

scholarly journals The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases

2021 ◽  
Vol 22 (12) ◽  
pp. 6541
Author(s):  
Kamila Kasprzak-Drozd ◽  
Tomasz Oniszczuk ◽  
Jakub Soja ◽  
Marek Gancarz ◽  
Karolina Wojtunik-Kulesza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Fruits And Vegetables ◽  
Biologically Active ◽  
In Vivo Studies ◽  
Ldl Oxidation ◽  
Plasma Antioxidant Capacity ◽  
Black Chokeberry ◽  
The Impact

Epidemiological studies have emphasized the association between a diet rich in fruits and vegetables and a lower frequency of occurrence of inflammatory-related disorders. Black chokeberry (Aronia melanocarpa L.) is a valuable source of biologically active compounds that have been widely investigated for their role in health promotion and cardiovascular disease prevention. Many in vitro and in vivo studies have demonstrated that consumption of these fruits is associated with significant improvements in hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia. The mechanisms for these beneficial effects include upregulation of endothelial nitric oxide synthase, decreased oxidative stress, and inhibition of inflammatory gene expression. Collected findings support the recommendation of such berries as an essential fruit group in a heart-healthy diet. The aim of this review was to summarize the reports on the impact of black chokeberry fruits and extracts against several cardiovascular diseases, e.g., hyperlipidemia, hypercholesterolemia, hypertension, as well as to provide an analysis of the antioxidant and anti-inflammatory effect of these fruits in the abovementioned disorders.

scholarly journals Dwelling or house vs nature (biologically active areas)

2021 ◽  
pp. 41-50
Author(s):  
Joanna Klimowicz
Keyword(s):  
Open Space ◽  
Positive Impact ◽  
Residential Buildings ◽  
Large City ◽  
Climatic Conditions ◽  
Biologically Active ◽  
Large Cities ◽  
Global Pandemic ◽  
Green Areas ◽  
The Impact

In the current global pandemic situation, more and more people are asking themselves where it is better to live. In a house or in an apartment? Of course, opinions are divided. However facing to be closure in the residential space, more and more people have considered the possibility of buying even a small plot of land giving the opportunity to enjoy the open space and communing with greenery. Foreclosure has resulted that many people now struggling with issues of exclusion and depression. The opportunity to get out and commune with nature can have a positive impact on a person’s mood and perception of their current situation. Large city agglomerations, often deprived of sufficient green areas, are not able to provide adequate living conditions. Architects and urban planners in recent decades have been trying to provide the most convenient solutions to improve the quality of life in large cities. There are numerous green areas in cities or housing estates, often connected with water reservoirs providing better micro climatic conditions. In objects, green walls and roofs are being introduced to increase the comfort of living. It is worth to analyze a contemporary resident approach to the choice of place to live, what is better for him - a house or a flat (apartment)? Is it better to live in a house with a garden or in an apartment with a large balcony overgrown with greenery? Is it better to locate the apartment in the city center or on the suburbs, where there are larger concentrations of greenery? The issues presented in this article relate to research related to life satisfaction in houses or apartments of city dwellers, as well as they complement the research related to the observation of the impact of greenery on the leveling of the Urban Heat Island. Greenery is one of the factors improving micro climatic conditions, it is a stabilizer of temperature and humidity. Residents of selected appartments and houses were asked in what environment they would like to live and what is most important for them in terms of comfort of living. This paper will present the results of surveys and research on UHI in relation to green areas and their introduction into residential buildings. The aim of this paper is to illustrate the how important is relationship between residents’ satisfaction of living place and the biologically active areas in their vicinity.

scholarly journals Тhе features of a personalized approach to the treatment of cardiovascular diseases during pregnancy

2021 ◽  
Vol 25 (3) ◽  
pp. 498-509
Author(s):  
D. G. Konkov ◽  
O. V. Bulavenko ◽  
N. V. Adamchuk ◽  
S. М. Kosianenko
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Animal Studies ◽  
Aortic Disease ◽  
Team Approach ◽  
Cardiovascular Pathology ◽  
Perinatal Pathology ◽  
History Of ◽  
The Impact

Annotation. For the cases of cardiovascular pathology during pregnancy include hypertensive disorders, hypercholesterolemia, myocardial infarction, cardiomyopathy, arrhythmias, valve disease, thromboembolic diseases, aortic disease and cerebrovascular pathology. Cardiovascular disease (CVD) is the leading cause of death from pregnancy in the world. Raising maternal age and comorbid diseases contribute to increased maternal mortality, also. When searching for literature, we used Medline systems from PubMed (2011). The search was adapted for Embase (2015 - 2021) and Scopus (2017 - 2021). Inclusion criteria were as follows: the impact of diseases of the cardiovascular system on pregnancy; the impact of pregnancy on the course of cardiovascular disease; features of diagnosis and prevention of women with CVD at the stage of preconception and during pregnancy; safety of drugs for the treatment of cardiovascular pathology during pregnancy; choice of drugs to prevent perinatal pathology in women with CVD; features of antenatal observation in CVD. We excluded from the study: references to 2011 (more than 10 years); not English; all methods that were not directly related to the pathology of the cardiovascular system during pregnancy; concomitant diseases that can lead to aggravation of pregnancy; animal studies. As a result, 76 studies were identified that were subject to final inclusion in the systematic review. Analysis of the identified literature sources showed that the preconception reproductive strategy to be developed by a multidisciplinary cardio-obstetric team is becoming important for women with a history of cardiovascular disease or for those with a history of familial preeclampsia. Cardio-obstetrics has become as an important multidisciplinary industry that requires a team approach to optimizing the clinical management of cardiovascular disease during pregnancy. Timely involvement of the cardio-obstetric group is crucial to prevent maternal morbidity and mortality during pregnancy and 1 year after delivery. A general understanding of the importance of the impact of cardiovascular disease on pregnancy and the impact of pregnancy on existing CVD should be a basic area of expertise for family medicine professionals, cardiologists, obstetricians and gynecologists. The given scientific and clinical review of sources of evidence-based medicine contains certain features of predictor diagnosis, prevention and treatment of manifested forms of cardiovascular diseases during pregnancy.

scholarly journals Telomerase as a Therapeutic Target in Cardiovascular Disease

2021 ◽  
Vol 41 (3) ◽  
pp. 1047-1061
Author(s):  
Jedrzej Hoffmann ◽  
Gavin Richardson ◽  
Judith Haendeler ◽  
Joachim Altschmied ◽  
Vicente Andrés ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Reverse Transcriptase ◽  
Telomere Length ◽  
Therapeutic Target ◽  
Genetic Disorders ◽  
Telomerase Reverse Transcriptase ◽  
Loss Of Function ◽  
Antioxidative Function ◽  
Underlying Mechanisms ◽  
The Impact

Shortened telomeres have been linked to numerous chronic diseases, most importantly coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function mutations and deletions in telomerase both accelerate telomere shortening but do not necessarily lead to a clinical phenotype associated with atherosclerosis, questioning the causal role of telomere length in cardiac pathology. The differential extranuclear functions of the 2 main components of telomerase, telomerase reverse transcriptase and telomerase RNA component, offer important clues about the complex relationship between telomere length and cardiovascular pathology. In this review, we critically discuss relevant preclinical models, genetic disorders, and clinical studies to elucidate the impact of telomerase in cardiovascular disease and its potential role as a therapeutic target. We suggest that the antioxidative function of mitochondrial telomerase reverse transcriptase might be atheroprotective, making it a potential target for clinical trials. Graphic Abstract: A graphic abstract is available for this article.

Sign in / Sign up

Export Citation Format

Share Document