scholarly journals Polydopamine-Based Surface Modification of ZnO Nanoparticles on Sericin/Polyvinyl Alcohol Composite Film for Antibacterial Application

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 503 ◽  
Author(s):  
Lisha Ai ◽  
Yejing Wang ◽  
Gang Tao ◽  
Ping Zhao ◽  
Ahmad Umar ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Composite Film ◽  
Performance Test ◽  
Mechanical Performance ◽  
Wound Dressings ◽  
Zno Nps ◽  
Water Contact ◽  
Loss Analysis

Silk sericin (SS) is a type of natural macromolecular protein with excellent hydrophilicity, biocompatibility and biodegradability, but also has very poor mechanical properties. To develop sericin-based wound dressings, we utilized polyvinyl alcohol (PVA) to reinforce the mechanical property of sericin by blending PVA and sericin, then modified zinc oxide nanoparticles (ZnO NPs) on SS/PVA film with the assistance of polydopamine (PDA) to endow SS/PVA film with antibacterial activity. Scanning electron microscopy, energy dispersive spectroscopy and X-ray powder diffraction demonstrated ZnO NPs were well grafted on PDA-SS/PVA film. Fourier transform infrared spectra suggested PDA coating and ZnONPs modification did not alter the structure of sericin and PVA. Water contact angle and swelling tests indicated the excellent hydrophilicity and swellability of ZnO NPs-PDA-SS/PVA composite film. Mass loss analysis showed ZnO NPs-PDA-SS/PVA film had excellent stability. The mechanical performance test suggested the improved tensile strength and elongation at break could meet the requirement of ZnO NPs-PDA-SS/PVA film in biomaterial applications. The antibacterial assay suggested the prepared ZnO NPs-PDA-SS/PVA composite film had a degree of antimicrobial activity against Escherichia coli and Staphylococcus aureus. The excellent hydrophilicity, swellability, stability, mechanical property and antibacterial activity greatly promote the possibility of ZnO NPs-PDA-SS/PVA composite film in antibacterial biomaterials application.

scholarly journals Effects of Ultrasonication Time on the Properties of Polyvinyl Alcohol/Sodium Carboxymethyl Cellulose/Nano-ZnO/Multilayer Graphene Nanoplatelet Composite Films

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1797
Author(s):  
Tengteng Ji ◽  
Rong Zhang ◽  
Xiaorong Dong ◽  
Dur E Sameen ◽  
Saeed Ahmed ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Composite Film ◽  
Carboxymethyl Cellulose ◽  
Composite Films ◽  
Sodium Carboxymethyl Cellulose ◽  
Multilayer Graphene ◽  
Zno Nps ◽  
Graphene Nanoplatelet ◽  
Ultrasonication Time

Ultrasonication-assisted solution casting was used to prepare polyvinyl alcohol (PVA)/sodium carboxymethyl cellulose (CMC)/nano-ZnO/multilayer graphene nanoplatelet (xGnP) composite films; the performances (mechanical properties, water vapor permeability (WVP), biodegradability and antibacterial activity) of these films were investigated as a function of the ZnO NPs:xGnP mass ratio and ultrasonication time. Intermolecular interactions among ZnO NPs, xGnP and the PVA/CMC matrix were shown to improve WVP, while X-ray diffraction and scanning electron microscopy analyses revealed that the internal reticular structure of ultrasound-treated PVA/CMC/ZnO NPs/xGnP composite films was in a fluffier state than that of the untreated composite films and the PVA/CMC film. The incorporation of ZnO NPs and xGnP into the composite film reduced its tensile strength and elongation at break, and increased antibacterial activity and biodegradability. In addition, we carried out the experiment of strawberry preservation and measured weight loss ratio, firmness, content of total soluble solids and titration acid. Finally, the composite film of 7:3 had the best preservation effect on strawberries. Thus, the obtained results paved the way to develop novel biodegradable composite films with antimicrobial activity for a wide range of applications.

scholarly journals A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1821 ◽  
Author(s):  
Yejing Wang ◽  
Rui Cai ◽  
Gang Tao ◽  
Peng Wang ◽  
Hua Zuo ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Composite Film ◽  
Photoelectron Spectroscopy ◽  
Mechanical Performance ◽  
Antimicrobial Property ◽  
Face Centered Cubic ◽  
Water Contact ◽  
X Ray ◽  
Agar Film ◽  
The Face

Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications.

ZnO nanoparticle-embedded silk fibroin–polyvinyl alcohol composite film: a potential dressing material for infected wounds

2018 ◽  
Vol 42 (17) ◽  
pp. 14620-14629 ◽  
Author(s):  
Priyanka P. Patil ◽  
Jagruti V. Meshram ◽  
Raghvendra A. Bohara ◽  
Shivdas G. Nanaware ◽  
Shivaji H. Pawar
Keyword(s):  
Polyvinyl Alcohol ◽  
Composite Film ◽  
Silk Fibroin ◽  
Zno Nanoparticle ◽  
Infected Wound ◽  
Zno Nps ◽  
Infected Wounds ◽  
Highly Effective

A highly effective composite film based on ZnO NPs, silk fibroin and PVA for an infected wound.

Synthesis and morphology control of nano-scaled magnesium hydroxide and its influence on the mechanical property and flame retardancy of polyvinyl alcohol

2019 ◽  
Vol 9 (6) ◽  
pp. 675-680
Author(s):  
Xiaodong Wang ◽  
Mingqing Yu ◽  
Lei Li ◽  
Xu Fan
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Reaction Time ◽  
Polyvinyl Alcohol ◽  
Composite Film ◽  
Magnesium Hydroxide ◽  
Flame Retardancy ◽  
Nanocomposite Film ◽  
Room Temperature ◽  
Precipitation Reaction

Nano-scaled magnesium hydroxide with the special appearance was synthesized by a water precipitation reaction at room temperature. The effects of surfactant, reaction time, reactant concentration on the morphology of nano-scaled magnesium hydroxide were investigated. The nanocomposite film was prepared by adding nano-sized magnesium hydroxide to polyvinyl alcohol. The mechanical property and flame retardancy of PVA nanocomposites were tested. The results showed that the mechanical properties and flame retardancy of the composite film were improved by adding nano-powders.

Preparation and Properties of the Drug-Loaded Films of Polyvinyl Alcohol-Graft-Fibroin Peptides

2011 ◽  
Vol 320 ◽  
pp. 202-209 ◽  
Author(s):  
Qun Wang ◽  
Lu Qi
Keyword(s):  
Mechanical Property ◽  
Water Vapor ◽  
Moisture Content ◽  
Polyvinyl Alcohol ◽  
Transmission Rate ◽  
Wound Dressings ◽  
Water Vapor Transmission Rate ◽  
Water Vapor Transmission ◽  
The Matrix ◽  
Model Drug

Research of biomaterials made from synthesized polymer and naturally occurring macromolecules is a promising subject. The paper reported a series of drug-loaded films manufactured by a method of solution casting, taking polyvinyl alcohol-graft-fibroin peptides (PVA-g-FP) obtained by a graft copolymerization of PVA with allyl fibroin peptides (AFP) as the polymer matrix and, the ornidazole as the model drug. The mechanical property, moisture content, dissolution degree，water absorption and water-vapor transmission rate of the films were determined respectively, and the crystalline of the films were characterized via X-ray diffraction, the morphology of the films and the dispersity profile of the drug ornidazole loaded in the matrix of PVA-g-FP were investigated via the scanning electronic microscopy (SEM). It was concluded that: with the increase of the graft efficiency of FP in the PVA-g-FP films, the mechanical property and the degree of crystalline reduced gradually; but the moisture content, dissolution degree and water-vapor transmission rate rised gradually, and especially, the dispersity of the drug loaded in the PVA-g-FP matrix improved evidently. The results may be useful in exploiting biomaterials such as artificial skin, drug delivery systems and wound dressings.

scholarly journals Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1130
Author(s):  
Mariana Pires Figueiredo ◽  
Ana Borrego-Sánchez ◽  
Fátima García-Villén ◽  
Dalila Miele ◽  
Silvia Rossi ◽  
...  
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Mechanical Performance ◽  
Release Kinetics ◽  
Wound Dressings ◽  
In Vitro Drug Release ◽  
Improved Performance ◽  
Double Hydroxide ◽  
Double Hydroxides

This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.

scholarly journals Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 713
Author(s):  
Nina Melnikova ◽  
Alexander Knyazev ◽  
Viktor Nikolskiy ◽  
Peter Peretyagin ◽  
Kseniia Belyaeva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Bacterial Cellulose ◽  
Zinc Oxide Nanoparticles ◽  
Wound Dressings ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Wound Model ◽  
And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

scholarly journals Curcumin-loaded polyvinyl butyral film with antibacterial activity

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 673-681
Author(s):  
Yanchao Qiao ◽  
Lijie Duan
Keyword(s):  
Mechanical Property ◽  
Thermal Stability ◽  
Antibacterial Activity ◽  
Polyvinyl Butyral ◽  
Counting Method ◽  
E Coli ◽  
Antibacterial Materials ◽  
Good Antibacterial Activity ◽  
Colony Counting ◽  
Widespread Interest

AbstractAntibacterial materials have found widespread interest in different fields nowadays. In this study, curcumin (Cur) was incorporated into the polyvinyl butyral (PVB) matrix by dissolving in ethanol for improving the functional properties of a pure PVB film. We found that Cur was uniformly dispersed in the PVB matrix, which showed good compatibility. Moreover, the incorporation of Cur could also improve thermal stability, hydrophilicity, and mechanical property. The UV-vis spectra of the PVB–Cur film demonstrated that the film could block ultraviolet radiation. Subsequently, the antibacterial activity of the PVB–Cur film was measured by the colony-counting method against S. aureus and E. coli. The results showed that the PVB–Cur film exhibited good antibacterial activity. Therefore, the PVB–Cur film was considered as a promising material for food and medical packaging applications.

scholarly journals Enhanced antibacterial activity of chitosan, guar gum and polyvinyl alcohol blend matrix loaded with amoxicillin and doxycycline hyclate drugs

2021 ◽  
pp. 103156
Author(s):  
Dure N. Iqbal ◽  
Syed Ehtisham-ul-Haque ◽  
Sundas Ahmad ◽  
Khadija Arif ◽  
Erum Akbar Hussain ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Guar Gum ◽  
Doxycycline Hyclate
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