scholarly journals Effect of Formulation on the Binding Efficiency and Selectivity of Precipitation Molecularly Imprinted Polymers

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2996 ◽  
Author(s):  
K. Lim ◽  
Clovia Holdsworth
Keyword(s):  
Molecularly Imprinted Polymers ◽  
1H Nmr Spectroscopy ◽  
Binding Capacity ◽  
Minimal Effect ◽  
Initiator Concentration ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Feed Formulation ◽  
Crosslinker Content ◽  
Selectivity Studies

This study investigated the effect of feed formulation: the template:functional monomer (T:fM) and functional monomer:crosslinker (fM:X) ratios as well as the initiator concentration, on the binding performance and selectivity of caffeine (CAF) and theophylline (THP) imprinted polymers obtained by precipitation polymerisation in acetonitrile at 60 °C using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) as functional monomer and crosslinker, respectively. Template incorporation, monitored by quantitative 1H-NMR spectroscopy, ranged from 8 to 77% and was found to be more favourable at both high and low T:fM ratios, low fM:X ratio and high initiator concentration. The resulting T:fM ratio in most MIPs were found to be lower than their feed ratios. Incorporation of THP into the polymers was observed to be consistently higher than CAF and, for most MIPs, the observed binding capacities represent less than 10% of the incorporated template. Improved imprinting factors were obtained from molecularly imprinted polymers (MIPs) with high crosslinker content, i.e., fM:X ratio of 1:10, and high initiator concentration, i.e., initiator:total monomer (I:tM) ratio of 1:5, while T:fM ratio (1:2 to 1:8) was found not to influence binding capacities and imprinting factors (IF). The NIPs showed no preference for either CAF or THP in competitive selectivity studies while MIPs were observed to bind preferentially to their template with THP displaying higher selectivity (72–94%) than CAF (63–84%). Template selectivity was observed to increase with increasing initiator concentration, with MIPs from I:tM ratio of 1:5 shown to be the most selective towards CAF (84%) and THP (93%). The fM:X ratio only showed minimal effect on MIP selectivity. Overall, for the MIP systems under study, template incorporation, binding capacity, imprinting factor and selectivity are enhanced at a faster rate of polymerisation using an I:tM ratio of 1:5. Polymer particles obtained were between 66 to 140 nm, with MIPs generally smaller than their NIP counterparts, and have been observed to decrease with increasing T:fM and fM:X ratios and increase with increasing initiator concentration.

Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

2008 ◽  
Vol 1138 ◽  
Author(s):  
Zhan Liu ◽  
David G. Bucknall ◽  
Mark G. Allen
Keyword(s):  
Contrast Medium ◽  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Crosslink Density ◽  
Binding Capacity ◽  
Water Soluble ◽  
Spectrometric Analysis ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
X Ray

AbstractThis work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

A High-Throughput Screening of N-Carbobenzoxy-L-Tryptophan Imprinted Polymers and their Application for Monolithic Chiral Stationary Phase

2012 ◽  
Vol 535-537 ◽  
pp. 1525-1528 ◽  
Author(s):  
Jian Qi ◽  
Li Guo ◽  
Hai Feng Sang
Keyword(s):  
Stationary Phase ◽  
Molecularly Imprinted Polymers ◽  
High Throughput Screening ◽  
Chiral Stationary Phase ◽  
Binding Capacity ◽  
Low Cost ◽  
Small Scale ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Chiral Selectivity

Molecular imprinting is a technique to prepare polymers with predetermined selectivity, specific recognition and predesigned affinity to a desired molecule. The stability and low cost of molecularly imprinted polymers (MIPs) render them attractive for a broad range of applications. Currently, MIP technique has been widely used in chiral separation. In this study, a series of molecularly imprinted polymers for N-Carbobenzoxy-L-tryptophan (N-Cbz-L-Trp) synthesized in different conditions were prepared in a small scale to simulate the monolithic chiral stationary phases (CSPs) primarily. By coupling in situ processing and batch rebinding evaluation, the type of functional monomers, which likely to affect the chiral selectivity of MIPs, was investigated. It was found that a MIP comprising a mixture of functional monomer 4-vinylpyridine (4-VP) and porogen 1-dodecanol/toluene exhibited the highest binding capacity and chiral selectivity for N-Carbobenzoxy-L-tryptophan. Thereafter, the monolithic MIP synthesized in screened optimum condition is used as chiral stationary phase in HPLC, which shows favourable separating capacity.

Binding capacity of molecularly imprinted polymers and their nonimprinted analogs

2015 ◽  
Vol 38 (24) ◽  
pp. 4240-4247 ◽  
Author(s):  
Zsanett Dorkó ◽  
Anett Szakolczai ◽  
Tatjana Verbić ◽  
George Horvai
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Adsorption and selectivity studies of direct and magnetite-cored molecularly imprinted polymers (MIPs and magMIPs) towards chosen chalcones investigated with various analytical methods

RSC Advances ◽  
2021 ◽  
Vol 11 (41) ◽  
pp. 25334-25347
Author(s):  
Mateusz Pawlaczyk ◽  
Maria Guć ◽  
Grzegorz Schroeder
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Analytical Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Selectivity Studies

The following article presents a method for obtaining molecularly imprinted polymers (MIPs) and their magnetic equivalents (magMIPs) using chalcones as imprinting molecules, and their application for direct and competitive chalcones' adsorption.

scholarly journals Membrane Emulsification Process as a Method for Obtaining Molecularly Imprinted Polymers

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2830
Author(s):  
Joanna Wolska ◽  
Nasim Jalilnejad Falizi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Sorption Process ◽  
Imprinted Polymer ◽  
Membrane Emulsification ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Emulsification Process

The membrane emulsification process (ME) using a metallic membrane was the first stage for preparing a spherical and monodisperse thermoresponsive molecularly imprinted polymer (TSMIP). In the second step of the preparation, after the ME process, the emulsion of monomers was then polymerized. Additionally, the synthesized TSMIP was fabricated using as a functional monomer N-isopropylacrylamide, which is thermosensitive. This special type of polymer was obtained for the recognition and determination of trace bisphenol A (BPA) in aqueous media. Two types of molecularly imprinted polymers (MIPs) were synthesized using amounts of BPA of 5 wt.% (MIP-2) and 7 wt.% (MIP-1) in the reaction mixtures. Additionally, a non-imprinted polymer (NIP) was also synthesized. Polymer MIP-2 showed thermocontrolled recognition for imprinted molecules and a higher binding capacity than its corresponding non-imprinted polymer and higher than other molecularly imprinted polymer (MIP-1). The best condition for the sorption process was at a temperature of 35 °C, that is, at a temperature close to the phase transition value for poly(N-isopropylacrylamide). Under these conditions, the highest levels of BPA removal from water were achieved and the highest adsorption capacity of MIP-2 was about 0.5 mmol g−1 (about 114.1 mg g−1) and was approximately 20% higher than for MIP-1 and NIP. It was also observed that during the kinetic studies, under these temperature conditions, MIP-2 sorbed BPA faster and with greater efficiency than its non-imprinted analogue.

Synthesis of nicotinamide-imprinted polymers and their binding performances in organic and aqueous media

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pattarawarapan Mookda ◽  
Komkham Singha ◽  
Kareuhanon Weeranuch ◽  
Tayapiwatana Chatchai
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Bulk Polymerization ◽  
Molar Ratio ◽  
Imprinted Polymer ◽  
Isolation And Identification ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractTo obtain molecularly imprinted polymers capable of selective rebinding with nicotinamide (NAM), NAM imprinted polymers were synthesized via bulk polymerization using various functional monomers and cross-linkers. The NAM recognition properties of these polymers were investigated in organic and aqueous solvents by equilibrium rebinding experiments. The results show that the imprinted polymer prepared using 1:4:4 molar ratio of NAM/MAA/TRIM in dichloromethane exhibited the greatest NAM binding capacity and selectivity. This polymer is potentially valuable for the analysis of NAM in complex matrices where selective isolation and identification are needed.

scholarly journals Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

RSC Advances ◽  
2014 ◽  
Vol 4 (60) ◽  
pp. 31507-31514 ◽  
Author(s):  
Zhong Zhang ◽  
Lingxin Chen ◽  
Fangfang Yang ◽  
Jinhua Li
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Shell Thickness ◽  
Binding Capacity ◽  
Correlation Study ◽  
Core Shell ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

A model of core–shell MIPs was constructed to evaluate the correlation between shell thickness and binding capacity.

Application of umbelliferone molecularly imprinted polymer in analysis of plant samples

2013 ◽  
Vol 67 (5) ◽  
Author(s):  
Katarína Hroboňová ◽  
Andrea Spevak ◽  
Ľubica Spišská ◽  
Jozef Lehotay ◽  
Jozef Čižmárik
Keyword(s):  
Molecularly Imprinted Polymers ◽  
High Performance ◽  
Limit Of Detection ◽  
Binding Capacity ◽  
Specific Binding ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Limit Of Determination ◽  
Pre Treatment

AbstractThe molecularly imprinted polymers (MIPs) were synthesised and the influence of the type of porogen, the nature of sample solvent, and the binding capacity of material were tested by high-performance liquid chromatography (HPLC). Umbelliferone was used as the template for imprint formation. Methacrylic acid was used as the monomer and acetonitrile, ethanol, and chloroform as porogen. Non-imprinted polymers (NIPs) were prepared by the same procedure. The highest value of the specific binding capacity (269 μg of umbelliferone per 100 mg of polymer) was obtained for polymers prepared in chloroform as porogen and methanol/water (φ r = 1: 1) as the sample solvent. The group-selective MIP was used as sorbent for the SPE pre-treatment of umbelliferone from plant extracts prior to HPLC analysis. Analysis of the spiked samples showed good recoveries (> 77 %). The limit of detection, limit of determination, and repeatability of the method were also calculated.

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