scholarly journals Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

RSC Advances ◽  
2014 ◽  
Vol 4 (60) ◽  
pp. 31507-31514 ◽  
Author(s):  
Zhong Zhang ◽  
Lingxin Chen ◽  
Fangfang Yang ◽  
Jinhua Li
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Shell Thickness ◽  
Binding Capacity ◽  
Correlation Study ◽  
Core Shell ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

A model of core–shell MIPs was constructed to evaluate the correlation between shell thickness and binding capacity.

Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

2008 ◽  
Vol 1138 ◽  
Author(s):  
Zhan Liu ◽  
David G. Bucknall ◽  
Mark G. Allen
Keyword(s):  
Contrast Medium ◽  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Crosslink Density ◽  
Binding Capacity ◽  
Water Soluble ◽  
Spectrometric Analysis ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
X Ray

AbstractThis work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

A High-Throughput Screening of N-Carbobenzoxy-L-Tryptophan Imprinted Polymers and their Application for Monolithic Chiral Stationary Phase

2012 ◽  
Vol 535-537 ◽  
pp. 1525-1528 ◽  
Author(s):  
Jian Qi ◽  
Li Guo ◽  
Hai Feng Sang
Keyword(s):  
Stationary Phase ◽  
Molecularly Imprinted Polymers ◽  
High Throughput Screening ◽  
Chiral Stationary Phase ◽  
Binding Capacity ◽  
Low Cost ◽  
Small Scale ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Chiral Selectivity

Molecular imprinting is a technique to prepare polymers with predetermined selectivity, specific recognition and predesigned affinity to a desired molecule. The stability and low cost of molecularly imprinted polymers (MIPs) render them attractive for a broad range of applications. Currently, MIP technique has been widely used in chiral separation. In this study, a series of molecularly imprinted polymers for N-Carbobenzoxy-L-tryptophan (N-Cbz-L-Trp) synthesized in different conditions were prepared in a small scale to simulate the monolithic chiral stationary phases (CSPs) primarily. By coupling in situ processing and batch rebinding evaluation, the type of functional monomers, which likely to affect the chiral selectivity of MIPs, was investigated. It was found that a MIP comprising a mixture of functional monomer 4-vinylpyridine (4-VP) and porogen 1-dodecanol/toluene exhibited the highest binding capacity and chiral selectivity for N-Carbobenzoxy-L-tryptophan. Thereafter, the monolithic MIP synthesized in screened optimum condition is used as chiral stationary phase in HPLC, which shows favourable separating capacity.

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