scholarly journals The Radiostability of Meropenem Trihydrate in Solid State

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2738 ◽  
Author(s):  
Karolina Kilińska ◽  
Judyta Cielecka-Piontek ◽  
Robert Skibiński ◽  
Daria Szymanowska ◽  
Andrzej Miklaszewski ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid State ◽  
Physical Stability ◽  
Chemical Degradation ◽  
Beam Radiation ◽  
Promising Alternative ◽  
X Ray ◽  
Lactam Ring ◽  
Ft Ir ◽  
Hydroxyethyl Group

The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed.

scholarly journals The Radiation Sterilization of Ertapenem Sodium in the Solid State

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2944
Author(s):  
Karolina Kilińska ◽  
Judyta Cielecka-Piontek ◽  
Robert Skibiński ◽  
Daria Szymanowska ◽  
Andrzej Miklaszewski ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
High Performance ◽  
Degradation Products ◽  
Radiation Sterilization ◽  
Scanning Calorimetry ◽  
Beam Radiation ◽  
Promising Alternative ◽  
Ft Ir ◽  
First Time

For the first time, the influence of ionising radiation on the physicochemical properties of ertapenem in solid state was studied. During our studies, we evaluated the possibility of applying radiosterilization to obtain sterile ertapenem. Spectroscopic (Fourier Transform Infrared (FT-IR)), thermal (differential scanning calorimetry (DSC), chromatography (High-Performance Liquid Chromatography (HPLC) and HPLC-MS), and X-ray powder diffraction (XRPD) studies shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of ertapenem irradiated with the dose of 25 kGy was only reduced for one species. Based on the received results, we can conclude that radiostelization is a promising alternative method of obtaining sterile ertapenem. In our studies, ertapenem was also exposed to e-beam radiation with a dose of 400 kGy. It was determined that two novel degradation products that are structurally differently to degradants formed during hydrolysis and thermolysis.

scholarly journals Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4492
Author(s):  
Eric Ofosu Kissi ◽  
Robin Nilsson ◽  
Liebert Parreiras Nogueira ◽  
Anette Larsson ◽  
Ingunn Tho
Keyword(s):  
Solid State ◽  
3D Printing ◽  
Solid Dispersion ◽  
Physical Stability ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Drug Load ◽  
X Ray ◽  
3D Printed ◽  
Hot Melt

Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate the influence of the drug load on printability and physical stability. The poor glass former naproxen (NAP) was hot-melt extruded with Kollidon® VA 64 at 10–30% w/w drug load. The extrudates (filaments) were characterised using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA). It was confirmed that an amorphous solid dispersion was formed. A temperature profile was developed based on the results from TGA, DSC, and DMA and temperatures used for 3D printing were selected from the profile. The 3D-printed tablets were characterised using DSC, X-ray computer microtomography (XµCT), and X-ray powder diffraction (XRPD). From the DSC and XRPD analysis, it was found that the drug in the 3D-printed tablets (20 and 30% NAP) was amorphous and remained amorphous after 23 weeks of storage (room temperature (RT), 37% relative humidity (RH)). This shows that adjusting the drug ratio can modulate the brittleness and improve printability without compromising the physical stability of the amorphous solid dispersion.

scholarly journals A Novel Cd(II) Isophthalate Complex with Triethanolamine: Crystal Structure, Fluorescence and Antimicrobial Activity

2021 ◽  
Vol 68 (2) ◽  
pp. 466-474
Author(s):  
Zuhal Yolcu ◽  
Sinem Yurtcan ◽  
Meryem Çıtlakoğlu
Keyword(s):  
Antimicrobial Activity ◽  
Room Temperature ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Single Crystal Diffraction ◽  
X Ray ◽  
Ft Ir ◽  
First Time ◽  
Trigonal Prismatic

A mixed ligand Cd(II) complex [Cd(IsoPht)(TEA)H2O]·3H2O was synthesized for the first time by using isophthalic acid (H2IsoPht) and tetradentate triethanolamine (TEA) and characterized by X-ray single-crystal diffraction, FT-IR, and thermogravimetric analysis (TGA). This novel complex crystallizes in the triclinic system with P-1 space group and distorted monocapped trigonal prismatic geometry. The Cd(II) has seven coordinates with bidentate IsoPht, a TEA in the tetradentate mode, and an aqua ligand. The fluorescence properties of the Cd(II) complex and TEA ligand were investigated at room temperature. The present Cd(II) complex was also tested for its antimicrobial activity by in vitro agar diffusion method against some Gram-positive and Gram-negative bacteria and a fungus.

scholarly journals Fabrication, Characterization, and Antimicrobial Activity, Evaluation of Low Silver Concentrations in Silver-Doped Hydroxyapatite Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
A. Costescu ◽  
C. S. Ciobanu ◽  
S. L. Iconaru ◽  
R. V. Ghita ◽  
C. M. Chifiriuc ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Raman Spectroscopy ◽  
Hydroxyl Groups ◽  
Major Public Health Problem ◽  
Hydroxyapatite Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ft Raman Spectroscopy ◽  
Ft Ir ◽  
Ft Raman

The aim of this study was the evaluation of(Ca10-xAgx)(PO4)6(OH)2nanoparticles (Ag:HAp-NPs) for their antibacterial and antifungal activity. Resistance to antimicrobial agents by pathogenic bacteria has emerged in the recent years as a major public health problem worldwide. In this paper, we report a comparison of the antimicrobial activity of low concentrations silver-doped hydroxyapatite nanoparticles. The silver-doped nanocrystalline hydroxyapatite powder was synthesized at 100°C in deionised water. The as-prepared Ag:Hap nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), FT-IR, and FT-Raman spectroscopy. X-ray diffraction (XRD) studies demonstrate that powders obtained by coprecipitation at 100°C exhibit the apatite characteristics with good crystal structure, without any new phase or impurities found. FT-IR and FT-Raman spectroscopy revealed the presence of the various vibrational modes corresponding to phosphates and hydroxyl groups and the absence of any band characteristic to silver. The specific microbiological assays demonstrated that Ag:HAp-NPs exhibited antimicrobial features, but interacted differently with the Gram-positive, Gram-negative bacterial and fungal tested strains.

scholarly journals Synthesis and structure of 1-benzyl-5-amino-1H-tetrazole in the solid state and in solution: Combining X-ray diffraction, 1H NMR, FT–IR, and UV–Vis spectra and DFT calculations

2015 ◽  
Vol 18 (4) ◽  
pp. 422-429 ◽  
Author(s):  
Ayyaz Mahmood ◽  
Islam Ullah Khan ◽  
Ricardo L. Longo ◽  
Ahmad Irfan ◽  
Sohail Anjum Shahzad
Keyword(s):  
Solid State ◽  
Dft Calculations ◽  
1H Nmr ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ft Ir

scholarly journals Formulating Drugs for Inhalers and Stability Issues

2012 ◽  
Vol 14 (4) ◽  
pp. 271
Author(s):  
R.C. Toon ◽  
E.C. Preedy ◽  
P. Prokopovich
Keyword(s):  
High Pressure ◽  
Solid State ◽  
Active Ingredient ◽  
Physical Stability ◽  
Chemical Degradation ◽  
Main Topic ◽  
Metered Dose Inhalers ◽  
Metered Dose ◽  
Stability Issues ◽  
Pressurised Metered Dose Inhalers

The main topic addressed in this paper is the formulation of pressurised metered dose inhalers and the problems associated with formulating medications for high pressure systems. Formulations for pressurised metered-dose inhalers (pMDIs) generally consist of two main types, solution and suspension-based systems. In the latter version, the active ingredient ideally remains mainly in the solid state, which can thus reduce problems with chemical degradation. However, the physical stability of such systems, in terms of aggregation, flocculation, creaming, sedimentation, propellant clathrates and bridging can then become problematic. The problems associated with solution-based systems revolve around the chemical<br />stability of the active ingredients.

Synthesis of Al3Ti(PO4)4.3333 and its Selectivity to Li+ Exchange

2012 ◽  
Vol 485 ◽  
pp. 442-445
Author(s):  
Heng Li
Keyword(s):  
Solid State ◽  
Ion Exchange ◽  
Exchange Capacity ◽  
Inverse Spinel ◽  
Spinel Type ◽  
Ion Exchange Capacity ◽  
X Ray ◽  
Crystallization Method ◽  
Ft Ir ◽  
Ft Ir Spectroscopy

The ion-exchanger Al3Ti(PO4)4.3333 of inverse spinel type was prepared by a solid state reaction crystallization method. The Li+ extraction/insertion with this material were investigated by X-ray, FT-IR spectroscopy, and Kd measurement, The chemical analysis showed that the Li+ extraction/insertion be progressed mainly by an ion-exchange mechanism. The acid treated samples had an ion exchange capacity of 8.2mmol/g for Li+. It had a memorial ion-sieve property for Li+.

Sign in / Sign up

Export Citation Format

Share Document