scholarly journals Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2571 ◽  
Author(s):  
Jerry Adeyemi ◽  
Damian Onwudiwe
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Molecular Structures ◽  
Tin Sulfide ◽  
Single Source ◽  
Hybrid Complex ◽  
Wide Range ◽  
Diverse Application ◽  
The Individual ◽  
Significant Attention

Significant attention has been given to organotin(IV) dithiocabamate compounds in recent times. This is due to their ability to stabilize specific stereochemistry in their complexes, and their diverse application in agriculture, biology, catalysis and as single source precursors for tin sulfide nanoparticles. These complexes have good coordination chemistry, stability and diverse molecular structures which, thus, prompt their wide range of biological activities. Their unique stereo-electronic properties underline their relevance in the area of medicinal chemistry. Organotin(IV) dithiocabamate compounds owe their functionalities and usefulness to the individual properties of the organotin(IV) and the dithiocarbamate moieties present within the molecule. These individual properties create a synergy of action in the hybrid complex, prompting an enhanced biological activity. In this review, we discuss the chemistry of organotin(IV) dithiocarbamate complexes that accounts for their relevance in biology and medicine.

scholarly journals Synthesis, Characterization and Biological Studies of Some Organotin Compounds: (A-Review)

2020 ◽  
Vol 36 (05) ◽  
pp. 871-878
Author(s):  
Priyanka Siwacha ◽  
Surbhi Soni ◽  
Harish Kumar Sharmaa ◽  
Manoj Kumara
Keyword(s):  
Amino Acids ◽  
Biological Activities ◽  
Organometallic Compounds ◽  
Molecular Structures ◽  
Organotin Compounds ◽  
Single Source ◽  
Biological Studies ◽  
Hybrid Complex ◽  
Wide Range ◽  
Significant Attention

Significant attention has been given to organotin (IV) amino acids compounds in recent years. Organometallic compounds are better known for their potentiality to stabilize peculiar stereochemistry of their complexes and application in agriculture, catalysis and as single source precursors. Due to the better stability and diverse molecular structures the complexes own a wide range of biological activities. These individual properties create an alliance of action in the hybrid complex. In this review, we discuss the chemistry of organotin (IV) complexes and their different aspects in various fields. The aim of the present review is to evaluate the synthesis, characterization and biological activities of organotin compounds.

Identification of promising objects for the synthesis of thiosulphonate derivatives of benzoquinone and hydroquinone

2021 ◽  
Vol 4 (2) ◽  
pp. 47-53
Author(s):  
N. Y. Monka ◽  
◽  
N. E. Stadnytska ◽  
I. R. Buchkevych ◽  
K. O. Kaplia ◽  
...  
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Experimental Studies ◽  
New Drugs ◽  
Reduced Form ◽  
Free Form ◽  
Wide Range ◽  
On Line ◽  
Living Organisms ◽  
Derivatives Of

Benzoquinone and its reduced form hydroquinone belong to phenolic compounds and are found in living organisms in free form or in glycosides. They are active substances of some medicinal plants and have a pharmacological effect on the human body. Accordingly, their derivatives are important objects for chemical synthesis and development of new drugs. This article presents the findings of the structural design of substances with benzoquinone or hydroquinone fragment and sulfur-containing compound. By use of appropriate on-line programs a predictive screening of the biological activity and cytotoxicity of thiosulfonate derivatives of benzoquinone and hydroquinone has been conducted. It has been found that they have immense methodological potential to be synthesized by substances with a wide range of biological activities and a high value of probable activity, which substantiates the feasibility of conducting experimental studies on their biological activity, particularly anticancer.

scholarly journals Fused 1,5-Naphthyridines: Synthetic Tools and Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3508
Author(s):  
Carme Masdeu ◽  
Maria Fuertes ◽  
Endika Martin-Encinas ◽  
Asier Selas ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Biological Activity ◽  
Metal Complexes ◽  
Biological Activities ◽  
Nitrogen Heterocycles ◽  
Diels Alder ◽  
Nitrogen Compounds ◽  
Wide Range ◽  
Oxygen Heterocycles ◽  
Optical Applications

Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. In this review, a wide range of synthetic protocols for the construction of this scaffold are presented. For example, Friedländer, Skraup, Semmlere-Wolff, and hetero-Diels-Alder, among others, are well known classical synthetic protocols used for the construction of the main 1,5-naphthyridine scaffold. These syntheses are classified according to the nature of the cycle fused to the 1,5-naphthyridine ring: carbocycles, nitrogen heterocycles, oxygen heterocycles, and sulphur heterocycles. In addition, taking into account the aforementioned versatility of these heterocycles, their reactivity is presented as well as their use as a ligand for metal complexes formation. Finally, those fused 1,5-naphthyridines that present biological activity and optical applications, among others, are indicated.

scholarly journals Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Lindsey E. Fox ◽  
Marissa C. Locke ◽  
Deborah J. Lenschow
Keyword(s):  
Viral Infections ◽  
Biological Activities ◽  
Type I Interferons ◽  
Type I ◽  
Disease States ◽  
Type I Ifns ◽  
Wide Range ◽  
Individual Type ◽  
Effector Cytokines ◽  
The Individual

Type I interferons (IFNs) are critical effector cytokines of the immune system and were originally known for their important role in protecting against viral infections; however, they have more recently been shown to play protective or detrimental roles in many disease states. Type I IFNs consist of IFNα, IFNβ, IFNϵ, IFNκ, IFNω, and a few others, and they all signal through a shared receptor to exert a wide range of biological activities, including antiviral, antiproliferative, proapoptotic, and immunomodulatory effects. Though the individual type I IFN subtypes possess overlapping functions, there is growing appreciation that they also have unique properties. In this review, we summarize some of the mechanisms underlying differential expression of and signaling by type I IFNs, and we discuss examples of differential functions of IFNα and IFNβ in models of infectious disease, cancer, and autoimmunity.

A Panoramic Review of Benzimidazole Derivatives and Their Potential Biological Activity

2022 ◽  
Vol 22 ◽  
Author(s):  
Hiram Hernández-López ◽  
Christian Jairo Tejada-Rodríguez ◽  
Socorro Leyva-Ramos
Keyword(s):  
Biological Activity ◽  
Hydrophobic Interactions ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Benzimidazole Derivatives ◽  
Drug Candidate ◽  
Hydrogen Bond Donor ◽  
Wide Range ◽  
Donor Acceptor ◽  
Potent Drug

Abstract: The therapeutic potential of the benzimidazole nucleus dates back to 1944, being and important heterocycle system due to its presence in a wide range of bioactive compounds such as antiviral, anticancer, antibacterial, and so on, where optimization of substituents in this class of pharmacophore has resulted in many drugs. Its extensive biological activity is due to its physicochemical properties like hydrogen bond donor-acceptor capability,  stacking interactions, coordination bonds with metals as ligands and hydrophobic interactions; properties that allow them to easily bind with a series of biomolecules, including enzymes and nucleic acids, causing a growing interest in these types of molecules. This review aims to present an overview to leading benzimidazole derivatives, as well as to show the importance of the nature and type of substituents at the N1, C2, and C5(6) positions, when they are biologically evaluated, which can lead to obtaining potent drug candidate with significant range of biological activities.

scholarly journals An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases

2019 ◽  
Vol 20 (17) ◽  
pp. 4101 ◽  
Author(s):  
Nand Kishor Roy ◽  
Dey Parama ◽  
Kishore Banik ◽  
Devivasha Bordoloi ◽  
Amrita Khwairakpam Devi ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Biological Activities ◽  
Boswellic Acid ◽  
Pentacyclic Triterpene ◽  
Boswellia Serrata ◽  
Wide Range ◽  
Molecular Mechanism Of Action ◽  
Inflammatory Bowel ◽  
Pharmacological Potential ◽  
Significant Attention

Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic diseases as they are devoid of major toxicities. Boswellic acid (BA), a series of pentacyclic triterpene molecules, is isolated from the gum resin of Boswellia serrata and Boswellia carteri. It proved to be one such agent that has exhibited efficacy against various chronic diseases like arthritis, diabetes, asthma, cancer, inflammatory bowel disease, Parkinson’s disease, Alzheimer’s, etc. The molecular targets attributed to its wide range of biological activities include transcription factors, kinases, enzymes, receptors, growth factors, etc. The present review is an attempt to demonstrate the diverse pharmacological uses of BA, along with its underlying molecular mechanism of action against different ailments. Further, this review also discusses the roadblocks associated with the pharmacokinetics and bioavailability of this promising compound and strategies to overcome those limitations for developing it as an effective drug for the clinical management of chronic diseases.

scholarly journals Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 791 ◽  
Author(s):  
Carla Fernandes ◽  
Maria Carraro ◽  
João Ribeiro ◽  
Joana Araújo ◽  
Maria Tiritan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Pharmacological Activities ◽  
Sar Studies ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Wide Range ◽  
Synthetic Methodologies ◽  
Derivatives Of ◽  
Biological And Pharmacological Activities

Many naturally occurring xanthones are chiral and present a wide range of biological and pharmacological activities. Some of them have been exhaustively studied and subsequently, obtained by synthesis. In order to obtain libraries of compounds for structure activity relationship (SAR) studies as well as to improve the biological activity, new bioactive analogues and derivatives inspired in natural prototypes were synthetized. Bioactive natural xanthones compromise a large structural multiplicity of compounds, including a diversity of chiral derivatives. Thus, recently an exponential interest in synthetic chiral derivatives of xanthones (CDXs) has been witnessed. The synthetic methodologies can afford structures that otherwise could not be reached within the natural products for biological activity and SAR studies. Another reason that justifies this trend is that both enantiomers can be obtained by using appropriate synthetic pathways, allowing the possibility to perform enantioselectivity studies. In this work, a literature review of synthetic CDXs is presented. The structures, the approaches used for their synthesis and the biological activities are described, emphasizing the enantioselectivity studies.

scholarly journals The effect of spruce stand thinning on biological activity in soil

2012 ◽  
Vol 49 (No. 11) ◽  
pp. 523-530 ◽  
Author(s):  
P. Formánek ◽  
V. Vránová
Keyword(s):  
Biological Activity ◽  
Soil Respiration ◽  
Biological Activities ◽  
Ammonium Nitrogen ◽  
Mountainous Area ◽  
Cellulose Decomposition ◽  
Spruce Stands ◽  
Biological Tests ◽  
Stand Thinning ◽  
The Individual

The effect of thinning of young spruce stands by 500 trees/ha on biological activity in the soil profile was studied in the mountainous area of the Moravian-Silesian Beskids. The biological activity of soil was determined under optimal laboratory conditions by tests of soil respiration, catalase activity and intensity of cellulose decomposition. No statistically significant differences were found between the individual biological tests when the two experimental stands were compared (P-level 0.05). All biological activities within each stand were correlated, and significant correlations were found between biological activities in the soil and ammonium nitrogen content.

scholarly journals The synthesis of angular heteroarenochromones based on 7-hydroxy-8-carbonylchromones

2017 ◽  
Vol 5 (2) ◽  
pp. 68-94 ◽  
Author(s):  
Tatyana Shokol ◽  
Oleg Lozinski ◽  
Natalia Gorbulenko ◽  
Volodymyr Khilya
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
The Other ◽  
Present Review ◽  
Synthetic Analogues ◽  
Naturally Occurring ◽  
Other Hand ◽  
Wide Range

The present review highlights advanced strategies to the synthesis of the chromones annulated with O- and N-containing heterocycles at C(7)-C(8) bond. Due to the prevalence of such motives in different kinds of natural flavonoids and some alkaloids, fused chromones have attracted a great deal of attention so far. On the other hand a wide range of biological activities is displayed by the compounds of this type both among naturally occurring flavonoids and their synthetic analogues. 8-Carbonyl-7-hydroxychromones proved to be versatile synthones for the synthesis of angular hetarenochromones via approach of annulation of a heterocycle to the chromone core. It also addresses the question of the biological activity of naturally occurring and fused synthetic hetarenochromones.

scholarly journals A Review on Synthesis and Biological Activity of Thiazole and its Derivatives

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Namitha TH ◽  
Saranya S Nair ◽  
Dr.Arun Kumar ◽  
Dr.Vinod B ◽  
Dr.Daisy P A
Keyword(s):  
Biological Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Synthetic Compounds ◽  
The Past ◽  
Current Review ◽  
Heteroaromatic Ring ◽  
Wide Range ◽  
Anti Inflammatory

Thiazole, a five-membered heteroaromatic ring, is an important framework of a large number of synthetic compounds. Its diverse pharmacological activity is mirrored in many clinically approved thiazole-containing molecules with, wide range of biological activities, such as antibacterial, antifungal, antiviral, anthelmintic, antitumor, and anti-inflammatory effects. The current review provides an overview of the biological activities of thiazole during the past years.

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