scholarly journals In Vitro Antioxidant Activities of Phenols and Oleanolic Acid from Mango Peel and Their Cytotoxic Effect on A549 Cell Line

Molecules ◽  
2018 ◽  
Vol 23 (6) ◽  
pp. 1395 ◽  
Author(s):  
Xuelian Bai ◽  
Tongfei Lai ◽  
Ting Zhou ◽  
Yicong Li ◽  
Xiuting Li ◽  
...  
Keyword(s):  
Cell Line ◽  
Oleanolic Acid ◽  
A549 Cell ◽  
Cytotoxic Effect ◽  
Antioxidant Activities ◽  
A549 Cell Line ◽  
Mango Peel

scholarly journals Synthesis, In Vitro Anticancer Activity and In Silico Study of some Benzylidene Hydrazide Derivatives

2020 ◽  
Vol 840 ◽  
pp. 277-283
Author(s):  
Melanny Ika Sulistyowaty ◽  
Galih Satrio Putra ◽  
Tutuk Budiati ◽  
Katsuyoshi Matsunami
Keyword(s):  
Cell Line ◽  
A549 Cell ◽  
In Silico ◽  
Protein Tyrosine Kinase ◽  
Human Lung ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Mtt Method ◽  
Lung Cancer A549 Cell

Some benzylidenehydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70% - 99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9μg/mL, which was linier with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.

In vitro photodynamic effect by phthalocyanine in A549 cell line

2007 ◽  
Author(s):  
Pavla Nevrelova ◽  
Hana Kolarova ◽  
Robert Bajgar ◽  
Miroslav Strnad
Keyword(s):  
Cell Line ◽  
A549 Cell ◽  
Photodynamic Effect ◽  
A549 Cell Line

scholarly journals Antioxidant and Proapoptotic Activities ofSclerocarya birrea[(A. Rich.) Hochst.] Methanolic Root Extract on the Hepatocellular Carcinoma Cell Line HepG2

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Maria Francesca Armentano ◽  
Faustino Bisaccia ◽  
Rocchina Miglionico ◽  
Daniela Russo ◽  
Nicoletta Nolfi ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Hepg2 Cells ◽  
Cytotoxic Effect ◽  
Antioxidant Activities ◽  
Dermal Fibroblasts ◽  
Root Extract ◽  
Dependent Manner ◽  
Mitochondrial Membrane Depolarization

The main goal of this study was to characterize thein vitroantioxidant activity and the apoptotic potential ofS. birreamethanolic root extract (MRE). Among four tested extracts, obtained with different solvents, MRE showed the highest content of polyphenols, flavonoids, and tannins together with antioxidant activities tested with superoxide, nitric oxide, ABTS, and beta-carotene bleaching assays. Moreover, the cytotoxic effect of MRE was evaluated on the hepatocarcinoma cell line HepG2. In these cells, MRE treatment induced apoptosis and generated reactive oxygen species (ROS) in dose-dependent manner. The cytotoxic effect promoted by MRE was prevented by pretreatment of HepG2 cells with N-acetyl-L-cysteine (NAC), suggesting that oxidative stress was pivotal in MRE-mediated cell death. Moreover, we showed that the MRE treatment induced the mitochondrial membrane depolarization and the cytochromecrelease from mitochondria into the cytosol. It suggests that the apoptosis occurred in a mitochondrial-dependent pathway. Interestingly, MRE showed a sensibly lower cytotoxicity, associated with a low increase of ROS, in normal human dermal fibroblasts compared to HepG2 cells. It is suggested that the methanolic root extract ofS. Birreais able to selectively increase intracellular ROS levels in cancer cells, promoting cell death.

scholarly journals Evaluation of Anticancer Activity of Olmesartan and Ramipril On A549 Cell Line

2018 ◽  
Vol 11 (3) ◽  
pp. 1351-1357 ◽  
Author(s):  
E Gayathri ◽  
K. Punnagai ◽  
D. Darling Chellathai
Keyword(s):  
Cell Cycle ◽  
Flow Cytometry ◽  
Anticancer Activity ◽  
Cell Line ◽  
A549 Cell ◽  
Enzyme Inhibitor ◽  
A549 Cell Line ◽  
Ic50 Values

Angiotensin Converting Enzyme Inhibitor (ACEI) and Angiotensin II type 1 receptor antagonist (ARBs) are the most efficient cardiovascular drugs and exhibited efficient cytostatic activity in vitro in many malignant and normal cells1.OBJECTIVE: This study aims to assess the anticancer activity of these two drugs in a dose dependant manner using A549 cell line through MTT assay and Cell cycle analysis.. MATERIALS AND METHODS: Ramipril and Olmesartan were added to A549 at various concentrations ranging from 10⁻⁶ to 10mM.The dot plot of the cytotoxicity results were used to extrapolate the IC50 values. The dot plot of flow cytometry results were used to extrapolate the DNA percentage in phases of cell cycle. The plates were read at 570 nm by using a PERCLIN ELMER (multimode reader). Measurements for concentration required for 50% inhibition was noted. RESULTS: Ramipril and Olmesartan were added to A549 at various concentrations ranging from 10⁻⁶ to 10mM.The dot plot of the cytotoxicity results were used to extrapolate the IC50 values. The dot plot of flow cytometry results were used to extrapolate the DNA percentage in phases of cell cycle.

scholarly journals Influence of Zedoary Oil on Cell Cycle and Cathepsin K Expression in A549 Cell Line in vitro

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Changfu Yang ◽  
Jianzhao Niu ◽  
yadong Li ◽  
Xiaobo Wang ◽  
Chunfang Huang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
A549 Cell ◽  
Cathepsin K ◽  
A549 Cell Line

scholarly journals In vitro host immune response against Acinetobacter baumannii infection using A549 cell line

2020 ◽  
Vol 101 ◽  
pp. 128-129
Author(s):  
H.J. Mea ◽  
P. Madhavan ◽  
N.K. Palanisamy ◽  
P. Yong ◽  
E.H. Wong
Keyword(s):  
Immune Response ◽  
Acinetobacter Baumannii ◽  
Cell Line ◽  
A549 Cell ◽  
Host Immune Response ◽  
A549 Cell Line

The effect of single and combined exposures to magnetite and polymorphous silicon dioxide nanoparticles on the human A549 cell line: in vitro study

2019 ◽  
Vol 26 (31) ◽  
pp. 31752-31762 ◽  
Author(s):  
Athena Rafieepour ◽  
Mansour R. Azari ◽  
Fariba Khodagholi ◽  
Jalal Pourahmad Jaktaji ◽  
Yadollah Mehrabi ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Cell Line ◽  
A549 Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
A549 Cell Line ◽  
Silicon Dioxide Nanoparticles ◽  
Combined Exposures ◽  
Human A549
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