scholarly journals Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length

Molecules ◽  
2018 ◽  
Vol 23 (6) ◽  
pp. 1316 ◽  
Author(s):  
Thomas Grosges ◽  
Dominique Barchiesi
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Thermal Ablation ◽  
Characteristic Length

Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity

2015 ◽  
Vol 21 (29) ◽  
pp. 4240-4251 ◽  
Author(s):  
Jun Zhao ◽  
Patrick Lee ◽  
Michael Wallace ◽  
Marites Melancon
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Therapy Efficacy

Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

2017 ◽  
Vol 53 (81) ◽  
pp. 11229-11232 ◽  
Author(s):  
Junghong Park ◽  
Swapan Pramanick ◽  
Jinhwan Kim ◽  
Jihyun Lee ◽  
Won Jong Kim
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles ◽  
Thermal Ablation ◽  
Specific Targeting

Nitric oxide-activatable gold nanoparticles can be utilized as a useful NO sensing tool and a photo-thermal agent for specific inflammation-associated macrophages.

scholarly journals Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach

2015 ◽  
Vol 17 (29) ◽  
pp. 18971-18979 ◽  
Author(s):  
Sílvia C. Coelho ◽  
Maria Rangel ◽  
Maria C. Pereira ◽  
Manuel A. N. Coelho ◽  
Galya Ivanova
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Structural Characterization ◽  
Au Nanoparticles ◽  
Functionalized Gold Nanoparticles ◽  
Loaded Surface

Structure of Bortezomib loaded, surface functionalized Au nanoparticles.

scholarly journals Irradiation Effects on Polymer-Grafted Gold Nanoparticles for Cancer Therapy

2018 ◽  
Vol 2 (1) ◽  
pp. 144-154 ◽  
Author(s):  
Marine Le Goas ◽  
Aurélie Paquirissamy ◽  
Dorra Gargouri ◽  
Giulia Fadda ◽  
Fabienne Testard ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Irradiation Effects

Light-Triggered Covalent Coupling of Gold Nanoparticles for Photothermal Cancer Therapy

ChemBioChem ◽  
2019 ◽  
Vol 20 (5) ◽  
pp. 667-671 ◽  
Author(s):  
Huawei Xia ◽  
Yinjia Gao ◽  
Ling Yin ◽  
Xiaju Cheng ◽  
Anna Wang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Covalent Coupling

scholarly journals A COMPARATIVE ANTICANCER STUDY OF BIOSYNTHESIZED NANOPARTICLES, DOXORUBICIN & NANO-DOX CONJUGATE AGAINST CERVICAL CANCER HELA CELL LINE

2020 ◽  
pp. 4-7
Author(s):  
M. R. Kamala Priya ◽  
Priya R. Iyer
Keyword(s):  
Cervical Cancer ◽  
Gold Nanoparticles ◽  
Cell Death ◽  
Cancer Therapy ◽  
Hela Cell ◽  
Cell Line ◽  
In Vitro Cytotoxicity ◽  
Hela Cell Line ◽  
Vero Cell Line

Doxorubicin is the most common chemotherapy drug used in cancer therapy. Its usage is associated with various side-effects. In order to overcome the challenges in Doxorubicin administration, the present study has focussed on synthesizing a drug conjugate with biosynthesized gold nanoparticles and doxorubicin. The gold nanoparticles were biosynthesized using green extracts of medicinal plants with potential anticancer activities. The nanoparticle that possesses anticancer activity was conjugated with the drug for a combinatorial effect of the nanoparticles and the drug. The in vitro cytotoxicity was checked in Vero cell line through MTT assay. The in vitro anti proliferative effects were screened against cervical cancer in HeLa cell line. Fluorescence activated cell sorting analysis was carried out to detect the difference between live and dead cell populations. The preliminary confirmation was carried out in UV-VIS spectrophotometer. The morphological characterization was carried out by SEM and stability by Zeta potential. The IC50 of the nanocompounds demonstrated anti-proliferative activity against cervical cancer similar to the chemotherapeutic drug, Doxorubicin; additionally in a much lesser concentration of the drug. The in vitro cytotoxicity exhibited high viability of cells in Vero cell line with minimum viability of 80% in all the tested concentrations. There was a synergistic effect of the nanoparticles along with the drug; thereby an enhanced therapeutic efficiency was achieved. FACS analysis showed 36% of cell death in Dox treated HeLa cells whereas 96% of cell death in Nano-Dox treated HeLa cells. Nano-Dox conjugate has demonstrated high anticancer effects than drug alone Doxorubicin. Further biosynthesized nanomaterials based drug formulation can be developed as a potential strategy in cancer therapy.

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