Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

2017 ◽  
Vol 53 (81) ◽  
pp. 11229-11232 ◽  
Author(s):  
Junghong Park ◽  
Swapan Pramanick ◽  
Jinhwan Kim ◽  
Jihyun Lee ◽  
Won Jong Kim
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles ◽  
Thermal Ablation ◽  
Specific Targeting

Nitric oxide-activatable gold nanoparticles can be utilized as a useful NO sensing tool and a photo-thermal agent for specific inflammation-associated macrophages.

scholarly journals Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

RSC Advances ◽  
2021 ◽  
Vol 11 (26) ◽  
pp. 16131-16141
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Siti Nadiah Zulkifli ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Chemotherapeutic Agent ◽  
Cell Targeting ◽  
Specific Targeting ◽  
Colorectal Cancer Cells ◽  
Cancer Cell Targeting

5-FU-PEGylated AuNPs-CD133 is designed to improve specific targeting of 5-FU against colorectal cancer cells which abundantly express CD133.

scholarly journals Molecular Enhancement of Thermal Ablation Therapies Using TNF-α-Coated Gold Nanoparticles in a Translational Model of Renal Tumors

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
R. Pedro ◽  
K. Thekke-Adiyat ◽  
M. Shenoi ◽  
R. Goel ◽  
S. Schmechel ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Thermal Ablation ◽  
Tumor Model ◽  
Renal Tumors ◽  
Rabbit Kidney ◽  
Thermal Lesion ◽  
Ablation Therapy ◽  
Treatment Groups ◽  
Thermal Ablation Therapy ◽  
Tnf Α

Thermal ablation therapies are currently used for the treatment of select renal masses. Such treatments are limited to tumors that are small (<3 cm diameter), exophytic, and away from vital structures such as ureter or intestine. Novel treatment approaches are geared towards increasing the size of the thermal lesion created, limiting damage to collateral normal tissues, reducing local recurrence and distant metastases as well as improving the imaging potential of the therapy. Previous studies have demonstrated the enhancement of thermal therapies in pre-clinical murine models of solid tumors by intravenously infusing 33 nm TNF-α and PEG coated gold nanoparticles (CYT-6091, Cytimmune Sciences Inc.) prior to ablation. This study investigates the enhancement of thermal ablation therapy by CYT-6091 in a translational animal model of renal tumors. New Zealand White rabbits (37 for radiofrequency ablation (RFA), 20 for cryoablation) had VX-2 tumors implanted into their bilateral kidneys. The tumors were allowed to grow for 14 days to a size of ∼1 cm. For RFA, the rabbits were split into 3 treatment groups of 10 rabbits each and a sham group of 7 rabbits. The groups were treated with CYT-6091 (200 μg/kg) only, RFA only, or CYT-6091 (200 μg/kg) followed 4 hours later by RFA. For cryoablation, 2 treatment groups of 10 rabbits each were used. The groups were treated with cryoablation only or CYT-6091 (200 μg/kg) followed 4 hours later by cryoablation. The kidneys were harvested 3 days later for RFA and 7 days later for cryoablation. Gross and microscopic measurements of the ablation size as well as histological analysis using H&E staining were performed. The RFA plus CYT-6091 group had a larger zone of complete cell death than the RFA only group when measured both on gross sectioning (0.32±0.03 vs. 0.22±0.07cm3, p=0.015) and on microscopic examination (0.30±0.07 vs. 0.23±0.03cm3, p=0.03). Overall this was a 23% increase in ablation volume. This difference in ablation size was due to a replacement of partially ablated tissue at the periphery in the RFA only group by completely ablated tissue in the RFA plus CYT-6091 group. Thus this zone of partially ablated tissue was smaller in the RFA plus CYT-6091 group than the RFA only group (0.08±0.02cm3 vs. 0.13±0.05cm3, p=0.01). Excessive tumor growth into the ablation lesion at day 7 following cryoablation prevented accurate measurements in these groups; however, a significant decrease in the rate of peritoneal carcinomatosis (metastases) was obtained in the cryo plus CYT-6091 group compared to the cryoablation alone group (1/10 vs. 8/10, p=0.04). We have shown that use of CYT-6091 prior to thermal ablation therapy in a rabbit kidney tumor model can minimize the zone of partial treatment at the periphery of the thermal lesion and thus maximize the complete kill zone in RFA while significantly decreasing the rate of metastases in cryoablation. These data provide preliminary evidence for the efficacy of adjuvant use of CYT-6091 for thermal ablation therapies in a large animal translational tumor model.

Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery

2014 ◽  
Vol 2 (31) ◽  
pp. 5003-5011 ◽  
Author(s):  
Hien T. T. Duong ◽  
Nik Nik M. Adnan ◽  
Nicolas Barraud ◽  
Johan S. Basuki ◽  
Samuel K. Kutty ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles ◽  
Controlled Release ◽  
Intracellular Delivery ◽  
Functional Polymers ◽  
No Donor ◽  
Biofilm Dispersal

Gold nanoparticles (size 10 nm) were designed to store and release nitric oxide (NO), by functionalizing their surfaces with functional polymers modified with NO-donor molecules.

Gold Nanoparticles-mediated Releasing of Nitric Oxide from RSNOs

2010 ◽  
Vol 49 ◽  
pp. S117
Author(s):  
Hongying Jia ◽  
Yang Liu ◽  
Xu Han ◽  
Qiu Tian ◽  
Libo Du
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles

Self-assembled AuNPs on sulphur-doped graphene: a dual and highly efficient electrochemical sensor for nitrite (NO2−) and nitric oxide (NO)

2017 ◽  
Vol 41 (16) ◽  
pp. 8347-8358 ◽  
Author(s):  
Sajad Ahmad Bhat ◽  
Sarwar Ahmad Pandit ◽  
Mudasir Ahmad Rather ◽  
Ghulam Mohd Rather ◽  
Nusrat Rashid ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles ◽  
Electrochemical Sensor ◽  
Highly Efficient ◽  
Doped Graphene ◽  
Self Assembled

Gold nanoparticles self-assembled over sulphur-doped graphene as a reusable electrocatalyst for selective and sensitive quantification of NO2− and NO.

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