Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles

Marcos Lorca; Cesar Morales-Verdejo; David Vásquez-Velásquez; Juan Andrades-Lagos; Javier Campanini-Salinas; Jorge Soto-Delgado; Gonzalo Recabarren-Gajardo; Jaime Mella

doi:10.3390/molecules23051191

Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles

Molecules ◽

10.3390/molecules23051191 ◽

2018 ◽

Vol 23 (5) ◽

pp. 1191 ◽

Cited By ~ 7

Author(s):

Marcos Lorca ◽

Cesar Morales-Verdejo ◽

David Vásquez-Velásquez ◽

Juan Andrades-Lagos ◽

Javier Campanini-Salinas ◽

...

Keyword(s):

Adrenergic Receptor ◽

3D Qsar ◽

Structure Activity Relationships ◽

Structure Activity

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Structure—Activity Relationships for alpha-1 Adrenergic Receptor Agonists and Antagonists

The alpha-1 Adrenergic Receptors - The Receptors ◽

10.1007/978-1-4612-4582-7_6 ◽

1987 ◽

pp. 211-265 ◽

Cited By ~ 7

Author(s):

Robert M. DeMarinis ◽

Margaret Wise ◽

J. Paul Hieble ◽

Robert R. Ruffolo

Keyword(s):

Adrenergic Receptor ◽

Structure Activity Relationships ◽

Receptor Agonists ◽

Structure Activity ◽

Receptor Agonists And Antagonists

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From Molecular Docking to 3D-Quantitative Structure-Activity Relationships (3D-QSAR): Insights into the Binding Mode of 5-Lipoxygenase Inhibitors

Molecular Informatics ◽

10.1002/minf.201100101 ◽

2012 ◽

Vol 31 (2) ◽

pp. 123-134 ◽

Cited By ~ 10

Author(s):

Gokcen Eren ◽

Antonio Macchiarulo ◽

Erden Banoglu

Keyword(s):

Molecular Docking ◽

3D Qsar ◽

Binding Mode ◽

Quantitative Structure ◽

Lipoxygenase Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationships of Phthalimide-Phenylpiperazines: A Novel Series of Potent and Selective α1a-Adrenergic Receptor Antagonists.

ChemInform ◽

10.1002/chin.200037167 ◽

2000 ◽

Vol 31 (37) ◽

pp. no-no

Author(s):

Gee-Hong Kuo ◽

Catherine Prouty ◽

William V. Murray ◽

Virginia Pulito ◽

Linda Jolliffe ◽

...

Keyword(s):

Adrenergic Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Three dimensional structure-activity relationships (3D-QSAR) for insect repellency of diastereoisomeric compounds: a hierarchical molecular overlay approach¶

SAR and QSAR in Environmental Research ◽

10.1080/10629360701303784 ◽

2007 ◽

Vol 18 (3-4) ◽

pp. 237-250 ◽

Cited By ~ 10

Author(s):

S. C. Basak ◽

R. Natarajan ◽

W. Nowak ◽

P. Miszta ◽

J. A. Klun

Keyword(s):

Three Dimensional ◽

3D Qsar ◽

Dimensional Structure ◽

Three Dimensional Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Molecular Overlay ◽

Overlay Approach

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Accessing the Anti-Proliferating Activity of Tankyrase-2 Inhibitors via 2D, 3D-QSAR and Molecular Docking: Assessment of Structure Activity Relationships

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2017.71203 ◽

2017 ◽

Keyword(s):

Molecular Docking ◽

3D Qsar ◽

Structure Activity Relationships ◽

Structure Activity ◽

Proliferating Activity

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Quantitative Structure-Activity Relationships (QSAR): A Review of 3D QSAR

Combinatorial Library Design and Evaluation ◽

10.1201/9781482270761-10 ◽

2001 ◽

pp. 151-176

Keyword(s):

3D Qsar ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Synthesis and structure-activity relationships among .alpha.-adrenergic receptor agonists of the phenylethanolamine type

Journal of Medicinal Chemistry ◽

10.1021/jm00181a008 ◽

1980 ◽

Vol 23 (7) ◽

pp. 738-744 ◽

Cited By ~ 15

Author(s):

Gerard Leclerc ◽

Jean Claude Bizec ◽

Nicole Bieth ◽

Jean Schwartz

Keyword(s):

Adrenergic Receptor ◽

Structure Activity Relationships ◽

Receptor Agonists ◽

Alpha Adrenergic Receptor ◽

Structure Activity

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Structure-activity relationships of isoeugenol-based chlorophenylpiperazine derivatives on serotonergic/adrenergic receptor, platelet aggregation, and lipid peroxidation

Drug Development Research ◽

10.1002/ddr.20373 ◽

2010 ◽

Vol 71 (5) ◽

pp. 285-293 ◽

Cited By ~ 2

Author(s):

Kuo-Ping Shen ◽

Wen-Tsan Chang ◽

Hui-Li Lin ◽

Li-Wen Chu ◽

Ing-Jun Chen ◽

...

Keyword(s):

Lipid Peroxidation ◽

Platelet Aggregation ◽

Adrenergic Receptor ◽

Structure Activity Relationships ◽

Structure Activity

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Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists

The alpha-2 Adrenergic Receptors ◽

10.1007/978-1-4612-4596-4_4 ◽

1988 ◽

pp. 115-186 ◽

Cited By ~ 10

Author(s):

Robert R. Ruffolo ◽

Robert M. DeMarinis ◽

Margaret Wise ◽

J. Paul Hieble

Keyword(s):

Adrenergic Receptor ◽

Structure Activity Relationships ◽

Receptor Agonists ◽

Structure Activity ◽

Receptor Agonists And Antagonists

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ChemInform Abstract: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS AMONG α-ADRENERGIC RECEPTOR AGONISTS OF THE PHENYLETHANOLAMINE TYPE

Chemischer Informationsdienst ◽

10.1002/chin.198048158 ◽

1980 ◽

Vol 11 (48) ◽

Author(s):

G. CECLERC ◽

J. C. BIZEC ◽

N. BIETH ◽

J. SCHWARTZ

Keyword(s):

Adrenergic Receptor ◽

Structure Activity Relationships ◽

Receptor Agonists ◽

Structure Activity

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