Synthesis and structure-activity relationships among .alpha.-adrenergic receptor agonists of the phenylethanolamine type

1980 ◽  
Vol 23 (7) ◽  
pp. 738-744 ◽  
Author(s):  
Gerard Leclerc ◽  
Jean Claude Bizec ◽  
Nicole Bieth ◽  
Jean Schwartz
Keyword(s):  
Adrenergic Receptor ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Alpha Adrenergic Receptor ◽  
Structure Activity

scholarly journals Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure–Activity Relationships

2019 ◽  
Vol 32 (11) ◽  
pp. 2353-2364 ◽  
Author(s):  
Hyejin Park ◽  
Un-Ho Jin ◽  
Asuka A. Orr ◽  
Stephanie P. Echegaray ◽  
Laurie A. Davidson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Ah Receptor ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Structure Activity

Regulation of canine platelet function II. Catecholamines

1983 ◽  
Vol 245 (1) ◽  
pp. R100-R109 ◽  
Author(s):  
K. M. Meyers ◽  
L. Y. Huston ◽  
R. M. Clemmons
Keyword(s):  
Arachidonic Acid ◽  
Adrenergic Receptor ◽  
Dense Granule ◽  
Platelet Response ◽  
Receptor Agonists ◽  
Alpha Adrenergic Receptor ◽  
Acid Metabolites ◽  
Induced Aggregation ◽  
The Relationship ◽  
Platelet Shape

The action of epinephrine (E) on canine platelet aggregation is described. Although E did not induce a change in platelet shape or aggregation, potentiation of aggregation induced by the following agents was observed at physiological E concentrations (that is, less than 10 nM/1): arachidonic acid; the dense granule agonists, ADP and serotonin (5-HT); and collagen. Epinephrine-induced potentiation was in part independent of formation of arachidonic acid metabolites, and E potentiated the aggregating action of the bivalent cationophore A23187. Potentiation was inhibited by alpha-adrenergic receptor antagonists phenoxybenzamine, phentolamine, and ergotamine, and mimicked by alpha-adrenergic receptor agonists norepinephrine, clonidine, and in some cases, phenylephrine. The beta-adrenergic receptor agonists isoproterenol and dobutamine inhibited ADP-induced aggregation, and this action was presented by pretreating the platelets with propranolol and dichloroisoproterenol. An augmentation of the aggregation response of platelets to arachidonic acid was observed in blood samples withdrawn when circulating catecholamines were elevated. The physiological implication of epinephrine acting as a gain controller that alters the relationship between actuating signal and the platelet response to an agonist is discussed.

scholarly journals Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists

2003 ◽  
Vol 11 (18) ◽  
pp. 3965-3973 ◽  
Author(s):  
Giorgio Tarzia ◽  
Andrea Duranti ◽  
Andrea Tontini ◽  
Gilberto Spadoni ◽  
Marco Mor ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Structure Activity
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