scholarly journals Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents

Molecules ◽  
2018 ◽  
Vol 23 (2) ◽  
pp. 295 ◽  
Author(s):  
Antonella Borrelli ◽  
Anna Tornesello ◽  
Maria Tornesello ◽  
Franco Buonaguro
Keyword(s):  
Cell Penetrating Peptides ◽  
Anti Cancer ◽  
Cell Penetrating

scholarly journals Identification and characterization of novel enhanced cell penetrating peptides for anti-cancer cargo delivery

Oncotarget ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 5944-5957 ◽  
Author(s):  
Xiguang Zhang ◽  
Jean Yves Brossas ◽  
Christophe Parizot ◽  
Jean Marc Zini ◽  
Angelita Rebollo
Keyword(s):  
Cell Penetrating Peptides ◽  
Cargo Delivery ◽  
Anti Cancer ◽  
Cell Penetrating ◽  
Identification And Characterization

scholarly journals Cell-penetrating peptides containing 2,5-diketopiperazine (DKP) scaffolds as shuttles for anti-cancer drugs: conformational studies and biological activity

2020 ◽  
Vol 56 (42) ◽  
pp. 5685-5688
Author(s):  
Lucia Feni ◽  
Linda Jütten ◽  
Sara Parente ◽  
Umberto Piarulli ◽  
Ines Neundorf ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Penetrating Peptides ◽  
Cancer Drugs ◽  
Cellular Membranes ◽  
Conformational Studies ◽  
Cellular Translocation ◽  
Anti Cancer ◽  
Cell Penetrating

Cargo-peptides approaching cellular membranes: influence of cyclization and stereochemistry on cellular translocation activity of a novel group of cell-penetrating peptides containing bifunctional diketopiperazine.

scholarly journals Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2504
Author(s):  
Qing Zhou ◽  
Xiotian Sun ◽  
Nicolas Pasquier ◽  
Parvaneh Jefferson ◽  
Trang T. T. Nguyen ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Transcriptional Activation ◽  
Leucine Zipper ◽  
Cell Penetrating Peptides ◽  
Multiple Tumor ◽  
Synthetic Cell ◽  
Anti Cancer ◽  
Cell Penetrating

Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic cell-penetrating peptides (Bpep and Dpep) designed to interfere with the formation of active leucine-zipper-based dimers by CEBPB and CEBPD, transcription factors implicated in multiple malignancies. Both peptides similarly promoted apoptosis of multiple tumor lines of varying origins, without such effects on non-transformed cells. Combined with other treatments (radiation, Taxol, chloroquine, doxorubicin), the peptides acted additively to synergistically and were fully active on Taxol-resistant cells. The peptides suppressed expression of known direct CEBPB/CEBPD targets IL6, IL8 and asparagine synthetase (ASNS), supporting their inhibition of transcriptional activation. Mechanisms by which the peptides trigger apoptosis included depletion of pro-survival survivin and a required elevation of pro-apoptotic BMF. Bpep and Dpep significantly slowed tumor growth in mouse models without evident side effects. Dpep significantly prolonged survival in xenograft models. These findings indicate the efficacy and potential of Bpep and Dpep as novel agents to treat a variety of cancers as mono- or combination therapies.

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