scholarly journals Rapid Screening and Identification of Daidzein Metabolites in Rats Based on UHPLC-LTQ-Orbitrap Mass Spectrometry Coupled with Data-Mining Technologies

Molecules ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 151 ◽  
Author(s):  
Wenjing Zhao ◽  
Zhanpeng Shang ◽  
Qinqing Li ◽  
Moran Huang ◽  
Wenbin He ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Data Mining ◽  
Rapid Screening ◽  
Orbitrap Mass Spectrometry ◽  
Screening And Identification

Rapid identification of polyphenols in Kudiezi injection with a practical technique of mass defect filter based on high-performance liquid chromatography coupled with linear ion trap/orbitrap mass spectrometry

2014 ◽  
Vol 6 (10) ◽  
pp. 3515-3523 ◽  
Author(s):  
Fang Wang ◽  
Jiayu Zhang ◽  
Peihua Yin ◽  
Zijian Wang ◽  
Luyan Dong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Ion Trap ◽  
Rapid Identification ◽  
Rapid Screening ◽  
Linear Ion Trap ◽  
Mass Defect ◽  
Orbitrap Mass Spectrometry ◽  
Screening And Identification ◽  
Mass Defect Filter

A practical methodology was developed for the rapid screening and identification of serial components in Kudiezi injection using a combination of LTQ-Orbitrap and MDF technology.

A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)—Application to Forensic Toxicology Cases in Malaysia

2019 ◽  
Vol 43 (7) ◽  
pp. 528-535 ◽  
Author(s):  
Fathiah A Zubaidi ◽  
Yeun-Mun Choo ◽  
Guan-Huat Tan ◽  
Hamimah Abd Hamid ◽  
Yap Ken Choy
Keyword(s):  
Mass Spectrometry ◽  
Whole Blood ◽  
Forensic Toxicology ◽  
Rapid Screening ◽  
Mass Spectrometry Technique ◽  
Relative Standard ◽  
Liquid Chromatography Tandem Mass ◽  
Screening And Identification ◽  
Spectrometry Technique

Abstract A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. The ATS-related drugs analyzed in this study include ephedrine, pseudoephedrine, amphetamine, methamphetamine, MDMA (3,4-Methylenedioxymethamphetamine), MDA (3,4-Methylenedioxyamphetamine), MDEA (3,4-Methylenedioxy-N-ethylamphetamine) and phentermine. The relative standard deviation for inter and intraday was less than 15% while recoveries ranged from 80% to 120% for all three matrices, i.e., whole blood, urine and dried blood stain. All compounds gave library matching percentage of more than 85% based on the purity. This method was proven to be simple and robust, and provide high confident results complemented with library matching confirmation.

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