scholarly journals Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)

Molecules ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 900 ◽  
Author(s):  
Raimundo de Oliveira Júnior ◽  
Christiane Ferraz ◽  
Juliane Silva ◽  
Ana de Oliveira ◽  
Tâmara Diniz ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antinociceptive Effect

Physicochemical Characterization and Antinociceptive Effect of β-cyclodextrin/Lippia pedunculosa Essential Oil in Mice

2018 ◽  
Vol 18 (9) ◽  
pp. 797-807 ◽  
Author(s):  
Paula dos Passos Menezes ◽  
Francielly de Oliveira Araujo ◽  
Tatianny Araujo Andrade ◽  
Igor Araujo Santos Trindade ◽  
Heitor Gomes de Araujo-Filho ◽  
...  
Keyword(s):  
Essential Oil ◽  
Physicochemical Properties ◽  
Water Solubility ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Antinociceptive Effect ◽  
Physicochemical Characterization ◽  
Good Tool ◽  
Main Challenge ◽  
Higher Temperature

Background: Some research studies have shown that Lippia pedunculosa essential oil (EOLP) has interesting biological activities. However, its low water solubility is the main challenge to achieve its therapeutic potential. In this context, Cyclodextrins (CDs) have been widely used in order to overcome this problem due to your capability to improve the physicochemical properties of drugs. Objective: In this perspective, the main goal of this study was to investigate how the improvement of the physicochemical properties of inclusion complexes (EOLP and β-CD) enhance the antinociceptive effect in mice. Methods: To achieve that, we prepared samples by Physical Mixture (PM), Paste Complexation (PC) and Slurry Complexation (SC) methods, followed by their physicochemical characterization. In addition, it was evaluated if the use of β-CD enhances the antinociceptive effect of EOLP in mice. Results: The analysis showed that rotundifolone (72.02%) was the major compound of EOLP and we found out based on DSC results that β-CD protected it from oxidation. In addition, TG techniques demonstrated that the best inclusion methods were PC and SC, due to their greater weight loss (10.8 and 11.6%, respectively) in the second stage (171-312°C), indicating that more complexed oil was released at the higher temperature than oil free. Other characteristics, such as changes in the typical crystalline form, and reduced particle size were observed by SEM and laser diffraction, respectively. The SC was the most effective complexation method, once the presence of rotundifolone was detected by FTIR. Based on that, SC method was used in all mice tests. In this regard, the number of paw licks was reduced for both compounds (all doses), but EOLP was more effective in reducing the nociceptive behavior. Conclusion: Therefore, CDs seem not to be a good tool to enhance the pharmacological properties of EOs rich in peroxide compounds such as rotundifolone.

scholarly journals Antinociceptive and Anti-edematous Activities of the Essential Oils of Two Balkan EndemicLaserpitium Species

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Višnja Popović ◽  
Silvana Petrović ◽  
Maja Tomić ◽  
Radica Stepanović-Petrović ◽  
Ana Micov ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Antinociceptive Effect ◽  
Dependent Manner ◽  
Paw Edema ◽  
Oral Gavage ◽  
Inflammatory Conditions ◽  
Pressure Test ◽  
Male Wistar Rats ◽  
Dose Dependent

In this paper antinociceptive and anti-edematous effects are examined of the essential oils of the underground parts of two Balkan endemic Laserpitium species (Apiaceae), L. zernyi and L. ochridanum. Furthermore, the essential oil of the underground parts of L. ochridanum is chemically characterised by GC and GC-MS. Antinociceptive and anti-edematous effects were measured in a rat model of localized inflammation, induced by carrageenan, using apparatus for the modified paw-pressure test, and plethysmometer, respectively. The effects of both Laserpitium essential oils were measured after oral gavage administration to male Wistar rats in doses of 25, 50 and 100 mg/kg. The main constituents of L. ochridanum essential oil were: α-pinene (33.2%), α-bisabolol (10.3%) and chamazulene (14.9%). The essential oil of L. zernyi was previously shown to be rich in α-pinene (31.6%) and α-bisabolol (30.9%). Both examined essential oils produced a significant dose-dependent antinociceptive effect. The corresponding ED50±SEM in producing antinociception were 45.9±4.9 mg/kg and 42.4±2.1 mg/kg for L. zernyi and L. ochridanum oil, respectively. Both essential oils also significantly reduced paw edema in a dose-dependent manner. The estimated ED50±SEM values for the anti-edematous effect were 36.3±4.5 mg/kg for L. zernyi oil and 45.1±11.3 mg/kg for L. ochridanum oil. These results suggest that the essential oils of both investigated Laserpitium species may be effective against pain and edema present in various inflammatory conditions.

Antinociceptive Effect and GC/MS Analysis ofRosmarinus officinalisL. Essential Oil from its Aerial Parts

Planta Medica ◽  
2009 ◽  
Vol 75 (05) ◽  
pp. 508-511 ◽  
Author(s):  
Ana Martínez ◽  
Maria González-Trujano ◽  
Francisco Pellicer ◽  
Francisco López-Muñoz ◽  
Andrés Navarrete
Keyword(s):  
Essential Oil ◽  
Antinociceptive Effect ◽  
Aerial Parts ◽  
Ms Analysis

scholarly journals Cyclodextrin‐complexed Lippia grata essential oil reduce c‐fos expression in the periaqueductal gray area following the antinociceptive effect in mice

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Pollyana Siqueira Lima ◽  
Angélica Lucchese ◽  
Jullyana Siqueira Quintans ◽  
Natália Barreto Rocha Souto ◽  
Roberta Santana Deodório Cardoso ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antinociceptive Effect ◽  
Periaqueductal Gray ◽  
Gray Area ◽  
Fos Expression

scholarly journals Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

Rodriguésia ◽  
2020 ◽  
Vol 71 ◽  
Author(s):  
Simone Sacramento Valverde ◽  
Stefânia Priscilla de Souza ◽  
Temistocles Barroso de Oliveira ◽  
Andressa Maia Kelly ◽  
Nathalia Ferreira Costa ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Gas Chromatography Mass Spectrometry ◽  
Aerial Parts ◽  
Germacrene D ◽  
Solidago Chilensis

Abstract Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil.

Antinociceptive effect of the essential oil of Lippia sidoides on mice

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
RM Marçal ◽  
DM Ptak ◽  
RR Krempser ◽  
MR Krempser ◽  
GC Cardoso ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antinociceptive Effect ◽  
Lippia Sidoides

scholarly journals Characterization of the Antinociceptive Activity from Stevia serrata Cav

Biomedicines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 79
Author(s):  
Millena S. Cordeiro ◽  
Daniel L. R. Simas ◽  
Juan F. Pérez-Sabino ◽  
Max S. Mérida-Reyes ◽  
Manuel A. Muñoz-Wug ◽  
...  
Keyword(s):  
Essential Oil ◽  
Mechanism Of Action ◽  
Enzyme Inhibitor ◽  
Antinociceptive Effect ◽  
Area Under The Curve ◽  
Treated Group ◽  
Hot Plate ◽  
Gastrointestinal Problems ◽  
Higher Doses

Background: Stevia serrata Cav. (Asteraceae), widely found in Guatemala, is used to treat gastrointestinal problems. The aim of this study was to demonstrate the antinociceptive and anti-inflammatory effects of the essential oil (EO) and the mechanism of action. Methods: EO was tested in chemical (capsaicin- and glutamate-induced licking response) or thermal (hot plate) models of nociception at 10, 30 or 100 mg/kg doses. The mechanism of action was evaluated using two receptor antagonists (naloxone, atropine) and an enzyme inhibitor (L-NAME). The anti-hyperalgesic effect was evaluated using carrageenan-induced nociception and evaluated in the hot plate. Results: All three doses of EO reduced licking response induced by glutamate, and higher doses reduced capsaicin-induced licking. EO also increased area under the curve, similar to the morphine-treated group. The antinociceptive effect induced by EO was reversed by pretreatment of mice with naloxone (1 mg/kg, ip), atropine (1 mg/kg, ip) or L-NAME (3 mg/kg, ip). EO also demonstrated an anti-hyperalgesic effect. The 100 mg/kg dose increased the latency time, even at 1 h after oral administration and this effect has been maintained until the 96th hour, post-administration. Conclusions: Our data suggest that essential oil of S. serrata presents an antinociceptive effect mediated, at least in part, through activation of opioid, cholinergic and nitrergic pathways.

scholarly journals Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves ofXylopia laevigatain Experimental Models

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
João Carlos C. Queiroz ◽  
Ângelo R. Antoniolli ◽  
Lucindo J. Quintans-Júnior ◽  
Renan G. Brito ◽  
Rosana S. S. Barreto ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Piriform Cortex ◽  
Experimental Models ◽  
Acute Administration ◽  
Nitrite Production ◽  
Leaf Essential Oil ◽  
Anti Inflammatory ◽  
Inflammatory Profile

Xylopia laevigata(Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects ofX. laevigataleaf essential oil (EOX) in animal models. Our EOX sample showed the presence ofγ-muurolene (17.78%),δ-cadinene (12.23%), bicyclogermacrene (7.77%), andα-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P<0.05orP<0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P<0.01orP<0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use ofX. laevigataby traditional medicine practitioners in the management of pain and inflammatory disorders.

scholarly journals Antinociceptive Effect of an Aqueous Extract and Essential Oil from Baccharis heterophylla

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 116
Author(s):  
Erika Castillejos-Ramírez ◽  
Araceli Pérez-Vásquez ◽  
Rafael Torres-Colín ◽  
Andrés Navarrete ◽  
Adolfo Andrade-Cetto ◽  
...  
Keyword(s):  
Essential Oil ◽  
Chlorogenic Acid ◽  
Aqueous Extract ◽  
Solid Phase ◽  
Antinociceptive Effect ◽  
Acid Methyl Ester ◽  
Gas Chromatography Mass Spectrometry ◽  
Second Phase ◽  
Active Components ◽  
Caffeoylquinic Acid

Infusions and poultices prepared from the aerial parts of Baccharis heterophylla Kunth (Asteraceae) are widely used in Oaxaca (Mexico) for relieving painful and inflammatory complaints. Therefore, the antinociceptive potential of an aqueous extract (31.6–316 mg/kg, p.o.) and essential oil (30–177 µg/paw, i.pl.) of the plant was assessed using the formalin test. Both preparations inhibited the formalin-induced nociception response (100–316 mg/kg and 100–177 µg/paw, respectively) during the test’s second phase. Chemical analysis of the aqueous extract revealed that the major active components were chlorogenic acid (1), 3,4-di-O-(E)-caffeoylquinic acid (2), 3,5-di-O-(E)-caffeoylquinic acid (3), 4,5-di-O-(E)-caffeoylquinic acid (4), 3,5-di-O-(E)-caffeoylquinic acid methyl ester (5), apigenin (6), genkwanin (7), acacetin (8). Compounds 1–5 and 8 are new for B. heterophylla. A high-pressure liquid chromatographic method for quantifying chlorogenic acid (1) and di-caffeoylquinic acids 2–4 in the plant was developed and validated. Analyses of the essential oil and the headspace solid-phase microextraction products, via gas-chromatography-mass spectrometry, revealed that the major volatiles were β-pinene, myrcene, D-limonene, β-caryophyllene, and α-caryophyllene, which have demonstrated antinociceptive properties.

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