scholarly journals Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice

Molecules ◽  
2017 ◽  
Vol 22 (5) ◽  
pp. 756 ◽  
Author(s):  
Canhong Wang ◽  
Xiaowei Huo ◽  
Li Gao ◽  
Guibo Sun ◽  
Cao Li
Keyword(s):  
Hepatoprotective Effect ◽  
Carboxymethyl Pachyman

Screening of traditional Saudi plants for hepatoprotective effect

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SI Alqasoumi ◽  
MS Abdel-Kader
Keyword(s):  
Hepatoprotective Effect

Hepatoprotective Effect of Curdrania tricuspidata Extracts against Oxidative Damage

2012 ◽  
Vol 41 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Ok-Kyung Kim ◽  
Jin-Nyoung Ho ◽  
Da-Eun Nam ◽  
Woo-Jin Jun ◽  
Kwon-Tack Hwang ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Hepatoprotective Effect

scholarly journals Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect

2020 ◽  
Vol Volume 15 ◽  
pp. 9049-9059
Author(s):  
Yusheng Zhao ◽  
Yue Zhang ◽  
Hui Kong ◽  
Meiling Zhang ◽  
Jinjun Cheng ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Hepatoprotective Effect ◽  
Paeoniae Radix

scholarly journals Hepatoprotective effect of galangin on carbon tetrachloride-induced hepatotoxicity via the LKB1/AMPK pathway

2021 ◽  
Vol 19 ◽  
pp. 205873922110008
Author(s):  
Meng Chen ◽  
Xinyan Song ◽  
Jifang Jiang ◽  
Lei Xing ◽  
Pengfei Wang
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Toxicity ◽  
Corn Oil ◽  
Histopathological Examination ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Group Model ◽  
Protective Effects ◽  
Model Group ◽  
Expression Levels

To investigate the protective effects of galangin on liver toxicity induced by carbon tetrachloride (CCl4) in mice. Mouse hepatotoxicity model was established by intraperitoneal injection (i.p.) of 10 ml/kg body weight CCl4 that diluted with corn oil to a proportion of 1:500 on Kunming mice. The mice were randomly divided into five groups named control group, model group, and 1, 5, and 10 mg/kg galangin group. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. Liver histopathological examination was observed via optical microscopy. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and glutathion (GSSG) were analyzed to assess oxidative stress. Finally, western blot assay was carried out to analyse the expression levels of total AMP-activated protein kinase (AMPK), phospho-AMPK (p-AMPK), total liver kinase B1 (LKB1), and phospho-LKB1 (p-LKB1). Compared with the control group, in the model group, the levels of AST, ALT, MDA, and GSSG increased significantly ( p < 0.01); the activity of SOD and GSH decreased significantly ( p < 0.01); and the histopathological examination revealed liver necrosis. However, treatment with galangin (5 and 10 mg/kg) significantly reversed these CCl4-induced liver damage indicators. Furthermore, treatment with galangin (10 mg/kg) significantly increased the p-AMPK and p-LKB1 expression levels ( p < 0.01). This study supports the hepatoprotective effect of galangin against hepatotoxicity, perhaps occurring mainly through the LKB1/AMPK-mediated pathway.

Sign in / Sign up

Export Citation Format

Share Document