scholarly journals Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Couple Preparations Improved by Chito-Oligosaccharide via Integral Pharmacokinetics

Molecules ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 654 ◽  
Author(s):  
Wei Zhou ◽  
Ailing Yin ◽  
Jinjun Shan ◽  
Shouchuan Wang ◽  
Baochang Cai ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Flos Lonicerae ◽  
Flos Lonicerae Japonicae

The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function

2016 ◽  
Vol 179 ◽  
pp. 280-290 ◽  
Author(s):  
Yoonjin Nam ◽  
Jong Mi Lee ◽  
Yiyi Wang ◽  
Hyun Su Ha ◽  
Uy Dong Sohn
Keyword(s):  
Intestinal Motility ◽  
Flos Lonicerae ◽  
Flos Lonicerae Japonicae

Fingerprint analysis of Flos Lonicerae japonicae using binary HPLC profiling

2006 ◽  
Vol 20 (6-7) ◽  
pp. 634-641 ◽  
Author(s):  
Famei Li ◽  
Bo Yuan ◽  
Zhili Xiong ◽  
Xiumei Lu ◽  
Feng Qin ◽  
...  
Keyword(s):  
Fingerprint Analysis ◽  
Flos Lonicerae ◽  
Flos Lonicerae Japonicae

Development of a new and environmentally-friendly method to evaluate phenolic compounds from Flos Lonicerae Japonicae with ultra-high performance supercritical fluid chromatography (UHPSFC) combined with chemometrics

2018 ◽  
Vol 10 (35) ◽  
pp. 4292-4300 ◽  
Author(s):  
Hai Jiang ◽  
Liu Yang ◽  
Xudong Xing ◽  
Meiling Yan ◽  
Bingyou Yang ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Supercritical Fluid ◽  
Phenolic Acids ◽  
Supercritical Fluid Chromatography ◽  
High Performance ◽  
Environmentally Friendly ◽  
Chemical Variation ◽  
Flos Lonicerae ◽  
Environmentally Friendly Method ◽  
Flos Lonicerae Japonicae

The chemical variation of 10 batches of Flos Lonicerae Japonicae from different geographical origins was investigated by quantitation of phenolic acids..

scholarly journals Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yanfang Gao ◽  
Huanwen Tang ◽  
Liang Xiong ◽  
Lijun Zou ◽  
Wenjuan Dai ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Viability ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Protective Effects ◽  
Concentration Dependent Manner ◽  
Flos Lonicerae ◽  
L02 Cells ◽  
Flos Lonicerae Japonicae

Hydroquinone (HQ) is widely used in food stuffs and is an occupational and environmental pollutant. Although the hepatotoxicity of HQ has been demonstrated both in vitro and in vivo, the prevention of HQ-induced hepatotoxicity has yet to be elucidated. In this study, we focused on the intervention effect of aqueous extracts of Flos lonicerae Japonicae (FLJ) on HQ-induced cytotoxicity. We demonstrated that HQ reduced cell viability in a concentration-dependent manner by administering 160 μmol/L HQ for 12 h as the positive control of cytotoxicity. The aqueous FLJ extracts significantly increased cell viability and decreased LDH release, ALT, and AST in a concentration-dependent manner compared with the corresponding HQ-treated groups in hepatic L02 cells. This result indicated that aqueous FLJ extracts could protect the cytotoxicity induced by HQ. HQ increased intracellular MDA and LPO and decreased the activities of GSH, GSH-Px, and SOD in hepatic L02 cells. In addition, aqueous FLJ extracts significantly suppressed HQ-stimulated oxidative damage. Moreover, HQ promoted DNA double-strand breaks (DSBs) and the level of 8-hydroxy-2′-deoxyguanosine and apoptosis. However, aqueous FLJ extracts reversed HQ-induced DNA damage and apoptosis in a concentration-dependent manner. Overall, our results demonstrated that the toxicity of HQ was mediated by intracellular oxidative stress, which activated DNA damage and apoptosis. The findings also proved that aqueous FLJ extracts exerted protective effects against HQ-induced cytotoxicity in hepatic L02 cells.

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