scholarly journals The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 504 ◽  
Author(s):  
Yang-Yang Shao ◽  
Yi-Ming Zhou ◽  
Min Hu ◽  
Jin-Ze Li ◽  
Cheng-Juan Chen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mast Cell Degranulation ◽  
Th2 Cytokine ◽  
Cytokine Balance

scholarly journals Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3114
Author(s):  
Xing Wang ◽  
Junfang Guo ◽  
Zhongqi Ning ◽  
Xia Wu
Keyword(s):  
Mast Cell ◽  
Chinese Medicine ◽  
Virtual Screening ◽  
Inhibitory Activity ◽  
Docking Studies ◽  
Mast Cell Degranulation ◽  
Amino Acid Residues ◽  
Tanshinone I ◽  
Syk Inhibitor

Spleen tyrosine kinase (Syk) is a critical target protein for treating immunoreceptor signalling-mediated allergies. In this study, a virtual screening of an in-house Chinese medicine database followed by biological assays was carried out to identify novel Syk inhibitors. A molecular docking method was employed to screen for compounds with potential Syk inhibitory activity. Then, an in vitro kinase inhibition assay was performed to verify the Syk inhibitory activity of the virtual screening hits. Subsequently, a β-hexosaminidase release assay was conducted to evaluate the anti-mast cell degranulation activity of the active compounds. Finally, tanshinone I was confirmed as a Syk inhibitor (IC50 = 1.64 μM) and exhibited anti-mast cell degranulation activity in vitro (IC50 = 2.76 μM). Docking studies showed that Pro455, Gln462, Leu377, and Lys458 were key amino acid residues for Syk inhibitory activity. This study demonstrated that tanshinone I is a Syk inhibitor with mast cell degranulation inhibitory activity. Tanshinone I may be a potential lead compound for developing effective and safe Syk-inhibiting drugs.

scholarly journals Petroleum extract of Farfarae Flos alleviates nasal symptoms by regulating the Th1-Th2 cytokine balance in a mouse model of Allergic Rhinitis

2021 ◽  
Vol 18 (2) ◽  
pp. 555-563
Author(s):  
Yongyan Wu ◽  
Xiaojuan Zhao ◽  
Jiajia Cui ◽  
Yujia Guo ◽  
Xiwang Zheng ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Th2 Cytokine ◽  
Nasal Symptoms ◽  
Cytokine Balance

scholarly journals ALLERGIC RHINITICAL THERAPY WITH ACUPUNCTURE, LEGUNDI AND TEMULAWAK HERBS

2019 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Maya Septriana ◽  
Novita Purnamasari ◽  
Herra Studiawan
Keyword(s):  
Allergic Rhinitis ◽  
Chinese Medicine ◽  
Acupuncture Therapy ◽  
Traditional Chinese Medicine ◽  
Combination Therapy ◽  
Immunoglobulin E ◽  
Nasal Congestion ◽  
Herbal Therapy ◽  
Runny Nose ◽  
Curcuma Xanthorrhiza

Background: Allergic rhinitis is an inflammatory disease of the nasal mucosa mediated by IgE (immunoglobulin E) with the main mediator histamine. Rhinitis in the science of Traditional Chinese Medicine (TCM) is called Bi Yuan (influenza) and Bi Zhi (nasal congestion). Cases of allergic rhinitis experienced by patients are complaints of repeated sneezing up to 10 times in the morning with rhinorrhea (runny nose). Patients classified as allergic rhinitis with differentiation of hot moist syndrome with splenic deficiency. Purpose: To prove the effect of acupuncture combination therapy on Yintang point (EXHN 3), Yinxiang (LI 20), Zusanli (ST 36), Taibai (SP 3) with herbal legundi (Vitex trifolia) and temulawak (Curcuma xanthorrhiza) in patients with allergic rhinitis. Methods: Handling allergic rhinitis with acupuncture and herbal therapy methods. Acupuncture therapy was carried out at Yintang point (EXHN 3), Yinxiang (LI 20), Zusanli (ST 36), Taibai (SP 3) with the principle of eliminating hot humidification and toning of the spleen. In herbal therapy, patients are given herbal legundi (Vitex trifolia) and ginger (Curcuma xanthorrhiza). Results: The active compounds viteosin-A, viteksikarpin, and vitetrifolin-E which can inhibit releasing  histamine and curcumin as anti-inflammatory have an effect on sneezing in allergic rhinitis. In handling allergic rhinitis, acupuncture therapy  given 12 times, once every two days. Herbal therapy  given for 14 times, taken every 2 days interval, 3 times a day with a dose of 5.2 grams of legundi and 4.2 grams of ginger. This therapy  overcome the symptoms of sneezing and rhinorrhea in allergic rhinitis. Conclusion: Acupuncture and herbal therapy can be used to overcome sneezing and rhinorrhea in allergic rhinitis.

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