Mesenchymal stem cells combined with traditional Chinese medicine (qi‐fang‐bi‐min‐tang) alleviates rodent allergic rhinitis

2019 ◽  
Vol 121 (2) ◽  
pp. 1541-1551
Author(s):  
Yanxia Fu ◽  
Yanhua Kong ◽  
Jun Li ◽  
Yi Wang ◽  
Mengdi Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Allergic Rhinitis ◽  
Mesenchymal Stem Cells ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine

scholarly journals Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yaxin Wang ◽  
Huicun Zhang ◽  
Hongbing Wang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Specific Mechanism ◽  
Improve Liver Function ◽  
Marrow Mesenchymal Stem Cells ◽  
Stem Cells Transplantation

Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

scholarly journals Atractylodes Lancea Volatile Oils Target ADAR2-miR-181a-5p Signaling to Mesenchymal Stem Cells Chondrogenic Differentiation

2021 ◽  
Author(s):  
Shanyu Ye ◽  
Wenwen Si ◽  
Wei Qin ◽  
Ziwei Luo ◽  
Zhen Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Chinese Medicine ◽  
Chondrogenic Differentiation ◽  
Volatile Oil ◽  
Luciferase Reporter ◽  
Blue Staining ◽  
Reporter System ◽  
Volatile Oils ◽  
Atractylodes Lancea

Abstract Background：The Rhizoma Atractylodis has long been recommended for the treatment of different diseases in traditional Chinese medicine. The main component of Rhizoma Atractylodis is Atractylodes lancea volatile oils which possesses anti-microorganism, anti-tumor, cognitive protection and immunoregulation. The aim of the study was to elucidate the mechanism of Atractylodes lancea volatile oils promoting mesenchymal stem cells (MSCs) chondrogenic differentiation. Method：Atractylodes lancea volatile oils were extracted from Chinese medicine Cangzhu by volatile oil extractor. MSCs culture were treated with Atractylodes lancea volatile oils medium. Real-time reverse transcription PCR was conducted to verify the candidate microRNAs discovered by microarray analysis. Western-blot analyzed the expressions of mark genes. Sanger sequences identified the changes of the base pairs which would be edited by ADAR2 enzyme. Toluidine blue staining identified the changes of cells chondrogenic differentiation. Result：Treatment of Atractylodes lancea volatile oils increased the cells chondrogenic differentiation of MSCs. Atractylodes lancea volatile oils promoted the expression of ADAR2 enzyme which may edit the precursor of miR-181a-5p. A dual luciferase reporter system assay verified that transcription factors yingyang1(YY1) was targeted by miR-181a-5p which was downregulated in MSCs chondrogenic differentiation. Conclusion：This work demonstrates the mechanism of Atractylodes lancea volatile oils promoting MSCs to chondrogenic differentiation. It may provide an alternative strategy for treatment purposes and diagnosis in clinic.

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