scholarly journals Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 433 ◽  
Author(s):  
Márton Pipicz ◽  
Gabriella Kocsis ◽  
László Sárváry-Arantes ◽  
Péter Bencsik ◽  
Zoltán Varga ◽  
...  
Keyword(s):  
Rat Heart ◽  
Low Dose ◽  
Late Preconditioning

scholarly journals Renoprotective immunosuppression by pioglitazone with low-dose cyclosporine in rat heart transplantation

2009 ◽  
Vol 138 (3) ◽  
pp. 744-751 ◽  
Author(s):  
Yosuke Tanaka ◽  
Tomomi Hasegawa ◽  
Zhi Chen ◽  
Yutaka Okita ◽  
Kenji Okada
Keyword(s):  
Heart Transplantation ◽  
Rat Heart ◽  
Low Dose

Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart

1998 ◽  
Vol 124 (3-4) ◽  
pp. 148-154 ◽  
Author(s):  
J. Wondergem ◽  
N. A. P. Franken ◽  
A. Chin ◽  
F. J. M. van Ravels ◽  
J. W. H. Leer
Keyword(s):  
Rat Heart ◽  
Low Dose ◽  
Ex Vivo ◽  
Cardiac Performance ◽  
Additive Effect ◽  
Thoracic Irradiation

scholarly journals Helium-induced late preconditioning in the rat heart in vivo †

2009 ◽  
Vol 102 (5) ◽  
pp. 614-619 ◽  
Author(s):  
R. Huhn ◽  
A. Heinen ◽  
N.C. Weber ◽  
S. Hieber ◽  
M.W. Hollmann ◽  
...  
Keyword(s):  
Rat Heart ◽  
Late Preconditioning

scholarly journals The dose-dependent effect of chronic Verapamil treatment on cardiac function in isolated rat heart with Hypertension

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
S Simovic ◽  
J Jeremic ◽  
G Davidovic ◽  
I Srejovic ◽  
V Zivkovic ◽  
...  
Keyword(s):  
Heart Rate ◽  
Rat Heart ◽  
Coronary Flow ◽  
Chronic Treatment ◽  
Low Dose ◽  
Isolated Rat Heart ◽  
High Dose ◽  
Chronotropic Effects ◽  
Dose Dependent ◽  
Isolated Rat

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Verapamil, a calcium channel blocker, is used for treatment of hypertension, paroxysmal supraventricular tachycardia  and angina pectoris. It primarily blocks L-type calcium channels preventing excessive influx of calcium into cardiomyocytes, leading to negative inotropic effect, and smooth muscle cells resulting in reduced relaxation of vasculature. With calcium antagonism it also causes negative chronotropic effect. However, there is no data on it’s dose-dependent effects on cardiac dynamic parameters and heart rate on isolated rat heart with hypertension. Purpose To investigate chronic, dose-dependent effects of Verapamil on cardiodynamic parameters in isolated rat heart with hypertension. Methods The present 4-week study was carried out on 24 spontaneously hypertensive Wistar Kyoto male rats  (6 weeks old): Control (n = 6), rats treated with 0.5 mg/kg/day of Verapamil (n = 6), rats treated with 5 mg/kg/day of Verapamil (n = 6) and rats treated with 50 mg/kg/day of Verapamil (n = 6). Isolated rat hearts were perfused on Langendorff perfusion apparatus. Results Chronic, low-dose Verapamil treatment significantly depressed function of all cardiodynamic parameters of the hypertensive heart when compared to the rats treated with higher doses of Verapamil (p < 0.001), except on the coronary flow and heart rate when compared to the Control (p= 0.137; p = 1.000, respectively). There was no significant differences between Verapamil in middle dose (5 mg/kg/day) and the Control group in inotropic (p = 0.415) and lusitropic (p = 1.000) effects, while it significantly lowered values of coronary flow (p = 0.002). It achieved significantly lower inotropic, lusitropic and chronotropic effects (p < 0.001) than high Verapamil dose and significantly better inotropic (p = 0.017), lusitropic (p < 0.001), but not chronotropic effects than low-dose Verapamil treatment (p = 0.179). High-dose, chronic treatment with Verapamil significantly intensified function of  the isolated rat heart with hypertension when compared to Control and lower doses of Verapamil (p < 0.001), without significant effects on coronary flow (p = 0.363). Conclusions Chronic treatment with Verapamil in high dose achieved better inotropic, chronotropic and lusitropic effects than treatment in low and middle doses of Verapamil, without significant effects on coronary flow. There is dose-depended effect of chronic Verapamil treatment on cardiac function of isolated rat heart with hypertension.

Xenon induces late preconditioning in rat heart in vivo - involvement of COX-II

2006 ◽  
Vol 23 (Supplement 37) ◽  
pp. 1
Author(s):  
J. Fraessdorf ◽  
N. C. Weber ◽  
C. Ratajczak ◽  
W. Schlack ◽  
B. Preckel
Keyword(s):  
Rat Heart ◽  
Late Preconditioning

Xenon induces late preconditioning in rat heart in vivo - involvement of COX-II

2006 ◽  
Vol 23 (Supplement 37) ◽  
pp. 65
Author(s):  
J. Fraessdorf ◽  
N. C. Weber ◽  
C. Ratajczak ◽  
W. Schlack ◽  
B. Preckel
Keyword(s):  
Rat Heart ◽  
Late Preconditioning
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