scholarly journals Evaluation of Maltose-Based Cationic Liposomes with Different Hydrophobic Tails for Plasmid DNA Delivery

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 406 ◽  
Author(s):  
Bo Li ◽  
Liangliang Deng ◽  
Meiyan Liu ◽  
Youlin Zeng
Keyword(s):  
Plasmid Dna ◽  
Dna Delivery ◽  
Cationic Liposomes

scholarly journals Arginine-based cationic liposomes for efficient in vitro plasmid DNA delivery with low cytotoxicity

2013 ◽  
pp. 1361 ◽  
Author(s):  
Shinji Takeoka ◽  
Sarker ◽  
Aoshima ◽  
Hokama ◽  
Inoue ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Delivery ◽  
Cationic Liposomes ◽  
Low Cytotoxicity

scholarly journals Physicochemical Factors That Influence the Biocompatibility of Cationic Liposomes and Their Ability to Deliver DNA to the Nuclei of Ovarian Cancer SK-OV-3 Cells

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 416 ◽  
Author(s):  
Mengwei Sun ◽  
Yuhao Yuan ◽  
Fake Lu ◽  
Anthony J. Di Pasqua
Keyword(s):  
Ovarian Cancer ◽  
Polyethylene Glycol ◽  
Plasmid Dna ◽  
Dna Delivery ◽  
Cationic Liposomes ◽  
Systemic Delivery ◽  
Pegylated Liposome ◽  
Molar Ratios ◽  
Physicochemical Factors ◽  
Insight Into

Cationic liposomes composed of 3-[N-(N’,N’-dimethylaminoethane)-carbamoyl] cholesterol (DC-chol) and dioleoylphosphatidylethanolamine (DOPE) have previously been shown to have applications in gene delivery. Our study aims to explore the effects of inclusion of polyethylene glycol (PEG) and using different molar ratios of DC-chol/DOPE on size, zeta potential, cytotoxicity and DNA delivery of DC-chol/DOPE liposomes. Our results show that PEGylation reduces the cytotoxicity of DC-chol/DOPE liposomes, and, furthermore, PEGylated liposome-DNA lipoplexes are smaller in size and more uniform in size distribution than those that are not PEGylated. Additionally, toxicity against ovarian cancer SKOV-3 cells decreases with the amount of cationic DC-chol present in the formulation; however, decreased delivery of DNA to cellular nuclei is also observed. Transfection with the PEGylated liposomes was successfully demonstrated using plasmid DNA with a known functional outcome. These results offer further insight into physicochemical properties important for cationic liposomes as vehicles for DNA delivery and demonstrate the potential of PEGylated DC-chol/DOPE liposomes as systemic delivery carriers for DNA-mediated ovarian cancer therapy.

scholarly journals Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride

2009 ◽  
Vol 19 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Takashi Yoshioka ◽  
Shohei Yoshida ◽  
Tomoaki Kurosaki ◽  
Mugen Teshima ◽  
Koyo Nishida ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Plasmid Dna ◽  
Dna Delivery ◽  
Cationic Liposomes

Evaluation of biocompatibility and efficiency of plasmid DNA delivery by gene-activated hydrogels in vitro

2019 ◽  
Vol XIV (2) ◽  
Author(s):  
I.Y. Bozo ◽  
A.A. Titova ◽  
M.N. Zhuravleva ◽  
A.I. Bilyalov ◽  
M.O. Mavlikeev ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Delivery

Efficient Cellular Entry of (r-x-r)-Type Carbamate–Plasmid DNA Complexes and Its Implication for Noninvasive Topical DNA Delivery to Skin

2016 ◽  
Vol 13 (6) ◽  
pp. 1779-1790 ◽  
Author(s):  
Manika Vij ◽  
Poornemaa Natarajan ◽  
Amit K. Yadav ◽  
Kiran M. Patil ◽  
Tanuja Pandey ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Delivery ◽  
Dna Complexes ◽  
Cellular Entry

Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery

2021 ◽  
Vol 56 (9) ◽  
pp. 5830-5844
Author(s):  
Elizabeth Hines ◽  
Dan Cheng ◽  
Weixi Wu ◽  
Meihua Yu ◽  
Chun Xu ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Plasmid Dna ◽  
Dna Delivery ◽  
Particle Sizes

Optimization of the Conditions for Plasmid DNA Delivery and Transfection with Self-Assembled Hyaluronic Acid-Based Nanoparticles

2018 ◽  
Vol 16 (1) ◽  
pp. 128-140 ◽  
Author(s):  
Hibah M Aldawsari ◽  
Harkiranpreet Kaur Dhaliwal ◽  
Bader Mubarak Aljaeid ◽  
Nabil A. Alhakamy ◽  
Zainy Mohammad Banjar ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Plasmid Dna ◽  
Dna Delivery ◽  
Self Assembled
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