scholarly journals Novel Coumarin-Containing Aminophosphonatesas Antitumor Agent: Synthesis, Cytotoxicity, DNA-Binding and Apoptosis Evaluation

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 14791-14809 ◽  
Author(s):  
Ya-Jun Li ◽  
Cai-Yi Wang ◽  
Man-Yi Ye ◽  
Gui-Yang Yao ◽  
Heng-Shan Wang
Keyword(s):  
Dna Binding ◽  
Antitumor Agent

Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent

2014 ◽  
Vol 74 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Ying Yi Chen ◽  
Pradeep B. Lukka ◽  
Wayne R. Joseph ◽  
Graeme J. Finlay ◽  
James W. Paxton ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Topoisomerase Ii ◽  
Antitumor Agent

DNA binding, cytotoxic effects and probable targets of an oxindolimine–vanadyl complex as an antitumor agent

2019 ◽  
Vol 43 (45) ◽  
pp. 17831-17840 ◽  
Author(s):  
Bruno Soares Dario ◽  
Francisco Fernandes Neto ◽  
Marcelo Cecconi Portes ◽  
Rodrigo Boni Fazzi ◽  
Daniel Rodrigues da Silva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Agent ◽  
Cytotoxic Effects ◽  
Vanadyl Complex

The vanadyl–oxindolimine complex as an antitumor agent.

DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives

2005 ◽  
Vol 15 (12) ◽  
pp. 2962-2965 ◽  
Author(s):  
Guoqiang Shangguan ◽  
Feifei Xing ◽  
Xiaogang Qu ◽  
Jianhua Mao ◽  
Dan Zhao ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Agent ◽  
Binding Specificity ◽  
Dna Binding Specificity

scholarly journals Molecular Mechanism of Inhibition of Survivin Transcription by the GC-rich Sequence-selective DNA Binding Antitumor Agent, Hedamycin

2005 ◽  
Vol 280 (10) ◽  
pp. 9745-9751 ◽  
Author(s):  
Jianguo Wu ◽  
Xiang Ling ◽  
Dalin Pan ◽  
Pasha Apontes ◽  
Lei Song ◽  
...  
Keyword(s):  
Dna Binding ◽  
Molecular Mechanism ◽  
Antitumor Agent ◽  
Mechanism Of Inhibition ◽  
Selective Dna Binding

DNA Binding Specificity and Cytotoxicity of Novel Antitumor Agent Ge132 Derivatives.

ChemInform ◽  
2005 ◽  
Vol 36 (43) ◽  
Author(s):  
Guoqiang Shangguan ◽  
Feifei Xing ◽  
Xiaogang Qu ◽  
Jianhua Mao ◽  
Dan Zhao ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Agent ◽  
Binding Specificity ◽  
Dna Binding Specificity

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

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