scholarly journals The Enhanced Inhibitory Effect of Different Antitumor Agents in Self-Microemulsifying Drug Delivery Systems on Human Cervical Cancer HeLa Cells

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 13226-13239 ◽  
Author(s):  
Zoltán Ujhelyi ◽  
Azin Kalantari ◽  
Miklós Vecsernyés ◽  
Eszter Róka ◽  
Ferenc Fenyvesi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Hela Cells ◽  
Drug Delivery Systems ◽  
Antitumor Agents ◽  
Inhibitory Effect ◽  
Delivery Systems ◽  
Human Cervical Cancer

scholarly journals The Inhibitory Effect of a Novel Polypeptide Fraction fromArca subcrenataon Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yu Wu ◽  
Xianjing Hu ◽  
Liyan Song ◽  
Jianhua Zhu ◽  
Rongmin Yu
Keyword(s):  
Cervical Cancer ◽  
Hela Cells ◽  
Molecular Mechanisms ◽  
Tumor Development ◽  
Basic Research ◽  
Inhibitory Effect ◽  
Fishery Resource ◽  
Proinflammatory Mediators ◽  
Raw264.7 Macrophage ◽  
Human Cervical Cancer

Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resourceArca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-αin human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy.

Development of Drug Targeting and Delivery in Cervical Cancer

2018 ◽  
Vol 18 (8) ◽  
pp. 792-806 ◽  
Author(s):  
Urvashi Aggarwal ◽  
Amit Kumar Goyal ◽  
Goutam Rath
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Side Effects ◽  
Targeted Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Treatment Options ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Delivery Strategies

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.

scholarly journals Internalization and Viability Studies of Suspended Nanowire Silicon Chips in HeLa Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 893 ◽  
Author(s):  
Sara Durán ◽  
Marta Duch ◽  
Rodrigo Gómez-Martínez ◽  
Marta Fernández-Regúlez ◽  
Juan Pablo Agusil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hela Cells ◽  
Silicon Nanowires ◽  
Drug Delivery Systems ◽  
Silicon Nanowire ◽  
Membrane Vesicles ◽  
Delivery Systems ◽  
Fundamental Study ◽  
Silicon Chips ◽  
Functional Features

Micrometer-sized silicon chips have been demonstrated to be cell-internalizable, offering the possibility of introducing in cells even smaller nanoelements for intracellular applications. On the other hand, silicon nanowires on extracellular devices have been widely studied as biosensors or drug delivery systems. Here, we propose the integration of silicon nanowires on cell-internalizable chips in order to combine the functional features of both approaches for advanced intracellular applications. As an initial fundamental study, the cellular uptake in HeLa cells of silicon 3 µm × 3 µm nanowire-based chips with two different morphologies was investigated, and the results were compared with those of non-nanostructured silicon chips. Chip internalization without affecting cell viability was achieved in all cases; however, important cell behavior differences were observed. In particular, the first stage of cell internalization was favored by silicon nanowire interfaces with respect to bulk silicon. In addition, chips were found inside membrane vesicles, and some nanowires seemed to penetrate the cytosol, which opens the door to the development of silicon nanowire chips as future intracellular sensors and drug delivery systems.

scholarly journals Glycosylated Nanoparticles for Cancer-Targeted Drug Delivery

2020 ◽  
Vol 10 ◽  
Author(s):  
Sergio Andrés Torres-Pérez ◽  
Cindy Estefani Torres-Pérez ◽  
Martha Pedraza-Escalona ◽  
Sonia Mayra Pérez-Tapia ◽  
Eva Ramón-Gallegos
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Molecular Mechanisms ◽  
Antitumor Agents ◽  
Delivery Systems ◽  
Lectin Receptors ◽  
Programmed Death ◽  
Therapeutic Value ◽  
Challenges And Opportunities

Nanoparticles (NPs) are novel platforms that can carry both cancer-targeting molecules and drugs to avoid severe side effects due to nonspecific drug delivery in standard chemotherapy treatments. Cancer cells are characterized by abnormal membranes, metabolic changes, the presence of lectin receptors, glucose transporters (GLUT) overexpression, and glycosylation of immune receptors of programmed death on cell surfaces. These characteristics have led to the development of several strategies for cancer therapy, including a large number of carbohydrate-modified NPs, which have become desirable for use in cell-selective drug delivery systems because they increase nanoparticle-cell interactions and uptake of carried drugs. Currently, the potential of NP glycosylation to enhance the safety and efficacy of carried therapeutic antitumor agents has been widely acknowledged, and much information is accumulating in this field. This review seeks to highlight recent advances in NP stabilization, toxicity reduction, and pharmacokinetic improvement and the promising potential of NP glycosylation from the perspective of molecular mechanisms described for drug delivery systems for cancer therapy. From preclinical proof-of-concept to demonstration of therapeutic value in the clinic, the challenges and opportunities presented by glycosylated NPs, with a focus on their applicability in the development of nanodrugs, are discussed in this review.

Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review

2016 ◽  
Vol 17 (3) ◽  
pp. 337-352 ◽  
Author(s):  
Umme Hani ◽  
Riyaz Ali M. Osmani ◽  
Rohit R. Bhosale ◽  
Hosakote Gurumallappa Shivakumar ◽  
Parthasarathi K. Kulkarni
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Comprehensive Review ◽  
Novel Drug

Fundamentals of Nanocarriers and Probiotics in the Treatment of Cervical Cancer

2020 ◽  
Vol 10 (4) ◽  
pp. 342-357
Author(s):  
Amandeep Singh ◽  
Deepa Negi ◽  
Simranjeet kaur ◽  
Sankha Bhattachary ◽  
Gurmeet Singh
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Drug Delivery Systems ◽  
Scientific Discovery ◽  
Therapeutic Option ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Laboratory Animals ◽  
Cancer Treatments ◽  
Probiotic Strains

Cancer is a pivotal disease, which is a serious concern towards scientific research. In the recent era of scientific discovery and innovation, probiotics have been proposed as a new preventive and therapeutic option in therapy and to control cancer growth. Probiotics may thus offer a new way in research to investigate active compounds in different probiotic strains having anticancer features. Studies in laboratory animals and cell lines with respect to cancer treatments are encouraging. With rare conventional treatments, the need for new alternatives as the transportation of chemotherapeutic agents by nanocarriers using nanotechnology is one such approach. This review considers various drug delivery systems used in the therapy of cervical cancer, such as dendrimers, liposomes and nanoparticles. These drug delivery systems assist in the improvement of pharmacological activity, solubility, bioavailability and, thus, facilitating new innovative therapeutic technologies. This review summarizes the application of nanotechnology and probiotics in the treatment of cervical cancer.

Mechanism of Coixen Ester Inducing Apoptosis of Human Cervical Cancer Hela Cells

2021 ◽  
Vol 7 (5) ◽  
pp. 3470-3478
Author(s):  
Li Zuo ◽  
Ting Li ◽  
Fuxiang Liu
Keyword(s):  
Cervical Cancer ◽  
Hela Cells ◽  
Inhibitory Effect ◽  
Positive Effects ◽  
Mtt Method ◽  
Growth Inhibitory ◽  
Anti Cancer ◽  
Induced Apoptosis ◽  
Inhibit Cell Proliferation ◽  
Human Cervical Cancer

Cervical cancer is a serious threat to women’s health. In recent years, the incidence rate has increased year by year, and the incidence of cervical cancer tends to be younger. Because of its characteristics of easy recurrence and easy metastasis, the drug therapy of cervical cancer has attracted increasing attention. Coixen ester has anti-cancer and immunomodulatory effects. After years of clinical research, it has been shown to be effective against a variety of cancers and has a growth inhibitory effect on tumor cells. This article aims to study the mechanism of Coixen ester-induced apoptosis of human cervical cancer HeLa cells. This article puts forward what are the causes of cervical cancer, and analyzes the positive effects of traditional Chinese medicine in the prevention and treatment of cervical cancer. During the experiment, the MTT method was used to study the effect of the complex on the proliferation of HeLa cells. The experimental results in this article show that a certain concentration of Coixen ester solution can inhibit cell proliferation and can also reduce cell viability to about 0.35.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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