scholarly journals A Facile Synthesis of α-N-Ribosyl-Asparagine and α-N-Ribosyl-Glutamine Building Blocks

Molecules ◽  
2013 ◽  
Vol 18 (8) ◽  
pp. 8779-8785 ◽  
Author(s):  
Gaetano Speciale ◽  
Anna Bernardi ◽  
Filippo Nisic
Keyword(s):  
Building Blocks ◽  
Facile Synthesis

Facile Synthesis of Guanidine Functionalised Building Blocks

2015 ◽  
Vol 4 (4) ◽  
pp. 320-326 ◽  
Author(s):  
Shane M. Hickey ◽  
Trent D. Ashton ◽  
Frederick M. Pfeffer
Keyword(s):  
Building Blocks ◽  
Facile Synthesis

scholarly journals Facile synthesis of N-doped graphene encapsulated Pd@N/C catalyst and its efficient application in cascade flow synthesis of amines

2021 ◽  
Author(s):  
Jianguo Liu ◽  
Jiangmin Sun ◽  
Yanpei Song ◽  
Shanshan Lin ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalyst ◽  
Primary Amine ◽  
Flow Reactor ◽  
Building Blocks ◽  
Primary Amines ◽  
Facile Synthesis ◽  
Flow Synthesis ◽  
Nitrogen Doped ◽  
Doped Graphene ◽  
Excellent Stability

Abstract N-methylamines, as an important class of chemicals, crucial building blocks, have been widely used in pharmaceutical companies and materials synthesis. Transition metal-catalyzed synthesis of N-methylamines, especially the heterogeneous catalyzed N-methylation of amines via different C1 sources has become the most promising methodology, due to the environmentally friendlier process and the recyclable and easily accessible catalysts. However, these reactions generally require activated toxic methyl iodide or dimethyl sulfoxide, and homogeneous catalysts or Raney nickel catalyst. The synthesis of amines still suffering from narrow scopes of amines, harsh reaction conditions, low selectivity of the desired products, and against the requirements of atomic economy and sustainable green environment. Herein, we developed a novel facile synthesis of nitrogen-doped graphene encapsulated Pd@NC nanocatalysts. The resulting heterogeneous catalyst was active for the synthesis of amines (more than 83 examples, yield up to 99%). The nitrogen-doped effect was unlike the previous report that poisoned the metal, it could increase the interaction with the active metal resulting in excellent stability. As far as we know, for the first time, the developed N-doped graphene encapsulated Pd@NC nanocatalyst showed excellent stability and activity of amines synthesis in the 20 times’ recycling test, industrially applicable flow reactor 2880 minutes’ test, and 99% purity of primary amine and tertiary amines product preparation test. Moreover, we have also shown the high atomic economy and environmentally friendlier tandem flow synthesis of N, N-dimethylamine products via the combination of reduction of nitrobenzene and N-methylation of amines, using the single one Pd@NC nanocatalyst with H2O as the only by-product. Upon our knowledge, this is a novel example of primary amine and tertiary amine synthesis methodology with the combined cascade reaction and flow process of nitrobenzene reduction and primary amines N-methylation with a single heterogeneous catalyst.

scholarly journals Facile Synthesis of 3-(Azol-1-yl)-1-adamantanecarboxylic Acids—New Bifunctional Angle-Shaped Building Blocks for Coordination Polymers

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2717 ◽  
Author(s):  
Dmitry Pavlov ◽  
Taisiya Sukhikh ◽  
Evgeny Filatov ◽  
Andrei Potapov
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Coordination Polymers ◽  
Building Blocks ◽  
X Ray Diffraction ◽  
Facile Synthesis ◽  
X Ray ◽  
Adamantanecarboxylic Acid ◽  
Concentrated Sulfuric Acid ◽  
First Time

For the first time, orthogonally substituted azole-carboxylate adamantane ligands were synthesized and used for preparation of coordination polymers. The angle-shaped ligands were prepared by the reaction of 1-adamantanecarboxylic acid and azoles (1H-1,2,4-triazole, 3-methyl-1H-1,2,4-triazole, 3,5-dimethyl-1H-1,2,4-triazole, 1H-tetrazole, 5-methyl-1H-tetrazole) in concentrated sulfuric acid. Variation of the solvent and substituents in azole rings allowed to prepare both 1D and 2D copper(II) and nickel(II) coordination polymers, [Cu2(trzadc)4(H2O)0.7]∙DMF∙0.3H2O, [Cu(trzadc)2(MeOH)]∙MeOH, [Ni(trzadc)2(MeOH)2] and [Cu2(mtrzadc)3(MeOH)]+NO3– (trzadc-3-(1,2,4-triazol-1-yl)-adamantane-1-carboxylic acid; mtrzadc-3-(3-methyl-1,2,4-triazol-1-yl)-adamantane-1-carboxylic acid) which were structurally characterized by single crystal X-ray diffraction. Complex [Cu(trzadc)2(MeOH)]∙MeOH was shown to act as a catalyst in the Chan-Evans-Lam arylation reaction.

ChemInform Abstract: Facile Synthesis of Highly Functionalized Bicyclo(3.2.1)octanes as Potential Building Blocks for Various Natural Products.

ChemInform ◽  
2010 ◽  
Vol 25 (38) ◽  
pp. no-no
Author(s):  
L. HADJIARAPOGLOU ◽  
A. DE MEIJERE ◽  
H.-J. SEITZ ◽  
I. KLEIN ◽  
D. SPITZNER
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Facile Synthesis
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