Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

2011 ◽  
Vol 54 (20) ◽  
pp. 7105-7126 ◽  
Author(s):  
Gordon W. Rewcastle ◽  
Swarna A. Gamage ◽  
Jack U. Flanagan ◽  
Raphael Frederick ◽  
William A. Denny ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pi3k Inhibitor ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Synthesis And Biological Evaluation ◽  
Phosphatidylinositol 3

Effects of rifampin on the pharmacokinetics of copanlisib, a novel pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor in cancer patients.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e14559-e14559
Author(s):  
Anna Spreafico ◽  
Michael B. Sawyer ◽  
Lillian L. Siu ◽  
Funan Huang ◽  
Susanne Reschke ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Pi3k Inhibitor ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

2019 ◽  
Vol 27 (8) ◽  
pp. 1529-1545 ◽  
Author(s):  
Anna C. Giddens ◽  
Swarna A. Gamage ◽  
Jackie D. Kendall ◽  
Woo-Jeong Lee ◽  
Bruce C. Baguley ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Biological Evaluation ◽  
Phosphatidylinositol 3 Kinase ◽  
Synthesis And Biological Evaluation ◽  
Phosphatidylinositol 3

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

2017 ◽  
Vol 25 (20) ◽  
pp. 5859-5874 ◽  
Author(s):  
Swarna A. Gamage ◽  
Anna C. Giddens ◽  
Kit Y. Tsang ◽  
Jack U. Flanagan ◽  
Jackie D. Kendall ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Biological Evaluation ◽  
Phosphatidylinositol 3 Kinase ◽  
Synthesis And Biological Evaluation ◽  
Phosphatidylinositol 3
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