scholarly journals Relaxant Effect of the Ethanol Extract of Helichrysum plicatum (Asteraceae) on Isolated Rat Ileum Contractions

Molecules ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 3391-3401 ◽  
Author(s):  
Dubravka Bigovic ◽  
Suzana Brankovic ◽  
Dusanka Kitic ◽  
Mirjana Radenkovic ◽  
Teodora Jankovic ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Relaxant Effect ◽  
Rat Ileum ◽  
Isolated Rat

Relaxant effect of capsazepine in the isolated rat ileum

2002 ◽  
Vol 365 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Emilia Nocerino ◽  
Angelo Izzo ◽  
Francesca Borrelli ◽  
Francesco Capasso ◽  
Raffaele Capasso ◽  
...  
Keyword(s):  
Relaxant Effect ◽  
Rat Ileum ◽  
Isolated Rat

scholarly journals Spasmolytic Activity of the Ethanol Extract of Sideritis raeseri spp. raeseri Boiss. & Heldr. on the Isolated Rat Ileum Contractions

2011 ◽  
Vol 14 (5) ◽  
pp. 495-498 ◽  
Author(s):  
Suzana Brankovic ◽  
Dusanka Kitic ◽  
Mirjana Radenkovic ◽  
Slavimir Veljkovic ◽  
Teodora Jankovic ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Isolated Rat

scholarly journals Relaxant activity of aqueous and ethanol extracts of parsley (Petroselinum crispum (Mill.) Nym. ex A.W. Hill, Apiaceae) on isolated ileum of rat

2010 ◽  
Vol 63 (7-8) ◽  
pp. 475-478 ◽  
Author(s):  
Suzana Brankovic ◽  
Dusanka Kitic ◽  
Mirjana Radenkovic ◽  
Vesna Ivetic ◽  
Slavimir Veljkovic ◽  
...  
Keyword(s):  
Aqueous Ethanol ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Petroselinum Crispum ◽  
Organ Bath ◽  
Dependent Manner ◽  
Response Curves ◽  
Rat Ileum ◽  
Ethanol Extracts ◽  
Isolated Rat

Introduction. Parsley (Petroselinum crispum) is used in the traditional herbal medicine to treat intestinal disorders. The aim of this study was to examine the effect of aqueous and ethanol extracts of parsley on spontaneous and acetylcholine induced contractions on isolated rat ileum. Material and methods. Wistar albino rats (250-300g) were used in this study. The ileum portions were isolated out and cleaned off mesenteries. Preparations 2 cm long were mounted in 20 ml tissue baths containing Tyrode's solution maintained at 37?C and aerated with a mixture of 5% carbon dioxide in oxygen. In the first part of experiments, contractile responses to the aqueous (ethanol) extracts of parsley were recorded. In the second part, increasing concentrations of acetylcholine were added to the organ bath for a full concentration response curve and then concentration response curves were obtained after adding the aqueous (ethanol) extracts of parsley. Results and discussion. Our results showed that aqueous (62.22?7.15%) and ethanol (79.16?9.34%) extracts of parsley in dose dependent manner decreased the tonus of spontaneous contractions of isolated rat ileum. The aqueous (32.16?2.75%) and ethanol (53.96?4.86%) extracts of parsley reduced the acetylcholine induced contraction, the reduction was greater with ethanol extract than with the aqueous one. Conclusion. It can be concluded that the aqueous and ethanol extracts of parsley exert antispasmodic activity on rat ileum. The relaxant effect of ethanol extract was better comparing to aqueous extract of parsley.

scholarly journals Characteristic of the vasorlaxant action of the talatisamine alkaloid and its derivatives

2021 ◽  
Vol 4 (2) ◽  
pp. 01-05
Author(s):  
Mirzayeva Yu.T.
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Channel Blocker ◽  
Aortic Ring ◽  
Diterpenoid Alkaloids ◽  
Relaxant Effect ◽  
Ring Contraction ◽  
Voltage Dependent ◽  
Ca2 Channels ◽  
Isolated Rat

The aim of our research is to study the effect relaxant action of diterpenoid alkaloids talatisamine, 14-O-benzoylthalatisamine and 14-O-acetylthalatisamine was studied using isolated rat aortic rings. Alkaloids significantly and dose-dependently inhibited contraction of the aortic rings caused by high KCl content. At the same time, under these conditions, alkaloids significantly reduced Ca2+-induced contraction of the aortic rings. The relaxing effects of alkaloids are significantly suppressed by verapamil, a potent potentiometer-dependent Ca2+ channel blocker. The alkaloids also significantly reduced norepinephrine-induced aortic ring contraction in normal as well as Ca2+ free Krebs solutions. The data obtained indicate that talatisamine, 14-benzoylthalatisamine and 14-O-acetylthalatisamine exhibit a pronounced relaxant effect in almost the same way in the case of contraction induced by a high content of KCl and norepinephrine. The mechanism of the relaxant action of alkaloids is probably complex and may include suppression of Ca2+influx through voltage-dependent and receptor-driven Ca2+ channels, as well as inhibition of Ca2+transport in the sarcoplasmic reticulum.

scholarly journals INHIBITORY EFFECT OF ETHANOLIC EXTRACT OF ERIOBOTRYA JAPONICA LEAVES PRE-INCUBATED WITH THEOPHYLLINE AND ASPIRIN ON ISOLATED GUINEA PIG TRACHEAL

2018 ◽  
Vol 11 (13) ◽  
pp. 46
Author(s):  
Marianne Marianne ◽  
Urip Harahap ◽  
Emil Salim ◽  
Dadang Irfan Husori ◽  
Fahrumsyah Jali Rambe ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protective Effect ◽  
Contractile Response ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Eriobotrya Japonica ◽  
Relaxant Effect ◽  
Significant Difference

 Objectives: The objectives of the study were to examine the inhibitory effect of ethanol extract of Eriobotrya japonica leaves (EEEJL) pre-incubated with theophylline and aspirin on isolated guinea pig tracheal chains against acetylcholine (ACh)-induced contraction.Methods: The effect of EEEJL (1-8 mg/Ml) on the isolated tracheal strips was tested in vitro. Furthermore, the mechanism of relaxant effects of EEEJL was evaluated in the presence of theophylline and aspirin.Results: The contractile response evoked by Ach (1.25 × 10−3 M) was decreased by EEEJL (effective concentration50 = 1.36 mg/mL) and has no significant difference of relaxant effect to that of EEEJL pre-incubated with theophylline and aspirin (p>0.05).Conclusion: The EEEJL decreased the ACh-induced contraction through the inhibition of PDE and the protective effect on prostaglandin E2.

scholarly journals Induction of functional activity and expression of mRNA of kinin B1 receptor in isolated rat ileum

2000 ◽  
Vol 82 ◽  
pp. 276
Author(s):  
Mineka Yoshimura ◽  
Hiroaki Naraba ◽  
Akinori Ueno ◽  
Sachiko Oh-ishi
Keyword(s):  
Functional Activity ◽  
Rat Ileum ◽  
B1 Receptor ◽  
Kinin B1 Receptor ◽  
Isolated Rat

Evaluation of the relaxant effect of levetiracetam on isolated rat duodenum

2016 ◽  
Vol 31 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Hesham A. Salem ◽  
Muhammad Y. Al-Shorbagy
Keyword(s):  
Relaxant Effect ◽  
Rat Duodenum ◽  
Isolated Rat

Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone

1981 ◽  
Vol 59 (8) ◽  
pp. 901-903 ◽  
Author(s):  
K. Nakatsu ◽  
E. Goldenberg ◽  
D. Penning ◽  
K. Jhamandas
Keyword(s):  
Dependent Manner ◽  
Narcotic Antagonist ◽  
Concentration Dependent Manner ◽  
Rat Ileum ◽  
Leucine Enkephalin ◽  
Isolated Rat

Both methionine- and leucine-enkephalin caused the isolated rat ileum to relax in a concentration-dependent manner; the EC50 values were in the order of 10−8 to 10−7 M. This isolated preparation was generally not sensitive to morphine. The enkephalin-induced inhibitions were not blocked by the classical narcotic antagonist, naloxone.

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