Evaluation of the relaxant effect of levetiracetam on isolated rat duodenum

2016 ◽  
Vol 31 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Hesham A. Salem ◽  
Muhammad Y. Al-Shorbagy
Keyword(s):  
Relaxant Effect ◽  
Rat Duodenum ◽  
Isolated Rat

scholarly journals Characteristic of the vasorlaxant action of the talatisamine alkaloid and its derivatives

2021 ◽  
Vol 4 (2) ◽  
pp. 01-05
Author(s):  
Mirzayeva Yu.T.
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Channel Blocker ◽  
Aortic Ring ◽  
Diterpenoid Alkaloids ◽  
Relaxant Effect ◽  
Ring Contraction ◽  
Voltage Dependent ◽  
Ca2 Channels ◽  
Isolated Rat

The aim of our research is to study the effect relaxant action of diterpenoid alkaloids talatisamine, 14-O-benzoylthalatisamine and 14-O-acetylthalatisamine was studied using isolated rat aortic rings. Alkaloids significantly and dose-dependently inhibited contraction of the aortic rings caused by high KCl content. At the same time, under these conditions, alkaloids significantly reduced Ca2+-induced contraction of the aortic rings. The relaxing effects of alkaloids are significantly suppressed by verapamil, a potent potentiometer-dependent Ca2+ channel blocker. The alkaloids also significantly reduced norepinephrine-induced aortic ring contraction in normal as well as Ca2+ free Krebs solutions. The data obtained indicate that talatisamine, 14-benzoylthalatisamine and 14-O-acetylthalatisamine exhibit a pronounced relaxant effect in almost the same way in the case of contraction induced by a high content of KCl and norepinephrine. The mechanism of the relaxant action of alkaloids is probably complex and may include suppression of Ca2+influx through voltage-dependent and receptor-driven Ca2+ channels, as well as inhibition of Ca2+transport in the sarcoplasmic reticulum.

Relaxant effect of capsazepine in the isolated rat ileum

2002 ◽  
Vol 365 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Emilia Nocerino ◽  
Angelo Izzo ◽  
Francesca Borrelli ◽  
Francesco Capasso ◽  
Raffaele Capasso ◽  
...  
Keyword(s):  
Relaxant Effect ◽  
Rat Ileum ◽  
Isolated Rat

The relaxing response of the isolated rat duodenum to nicotine

1988 ◽  
Vol 19 (5) ◽  
pp. 655-659 ◽  
Author(s):  
C.R.C. Guimaraes ◽  
L.A. Rodrigues ◽  
O. Vettore ◽  
A. Antonio
Keyword(s):  
Rat Duodenum ◽  
Relaxing Response ◽  
Isolated Rat

Developmental changes in response to endothelins and receptor subtypes of isolated rat duodenum

1995 ◽  
Vol 275 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Kaoru Irie ◽  
Yoko Uchida ◽  
Emiko Fujii ◽  
Takamura Muraki
Keyword(s):  
Developmental Changes ◽  
Receptor Subtypes ◽  
Rat Duodenum ◽  
Isolated Rat

scholarly journals Relaxant Effect of the Ethanol Extract of Helichrysum plicatum (Asteraceae) on Isolated Rat Ileum Contractions

Molecules ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 3391-3401 ◽  
Author(s):  
Dubravka Bigovic ◽  
Suzana Brankovic ◽  
Dusanka Kitic ◽  
Mirjana Radenkovic ◽  
Teodora Jankovic ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Relaxant Effect ◽  
Rat Ileum ◽  
Isolated Rat

Endothelium-Dependent Induction of Vasorelaxation by the Butanol Extract of Phellinus igniarius in Isolated Rat Aorta

2006 ◽  
Vol 34 (04) ◽  
pp. 655-665 ◽  
Author(s):  
Dae Gill Kang ◽  
Li Hua Cao ◽  
Jun Kyoung Lee ◽  
Deok Ho Choi ◽  
Seung Ju Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta ◽  
Dependent Manner ◽  
Vascular Relaxation ◽  
Relaxant Effect ◽  
Phellinus Igniarius ◽  
Butanol Extract ◽  
Cgmp Signaling ◽  
Dose Dependent ◽  
Isolated Rat

The butanol extract of Phellinus igniarius (BPI) induced relaxation of the phenylephrin e-precontracted rat aorta in a dose-dependent manner, and its effect was abolished by the removal of functional endothelium. Pretreatment of the aortic tissues with NG -nitro-L-arginine methyl ester (L-NAME), methylene blue, or 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin1-one (ODQ) inhibited the vascular relaxation induced by BPI. BPI-induced vascular relaxations were also markedly attenuated by the addition of verapamil or diltiazem, while the relaxant effect of BPI was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolol. Incubation of endothelium-intact rat aorta with BPI increased the production of cGMP in a dose-dependent manner. These results suggest that BPI dilates vascular smooth muscle via endothelium-dependent nitric oxide-cGMP signaling pathway, with the possible involvement of L-type Ca 2+ channels.

Relaxant effect of atorvastatin on isolated rat gastric fundus strips: implications for Ca2+-signalling mechanisms

2019 ◽  
Vol 97 (5) ◽  
pp. 413-421 ◽  
Author(s):  
Deniz Kaleli-Durman ◽  
F. İlkay Alp-Yıldırım ◽  
Osman Özdemir ◽  
B. Sönmez Uydeş-Doğan
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Mevalonate Pathway ◽  
Muscle Tone ◽  
Gastric Fundus ◽  
Lipid Lowering ◽  
Nitric Oxide Synthase Inhibitor ◽  
Relaxant Effect ◽  
Rat Gastric Fundus ◽  
Isolated Rat

Statins are determined to have various pleiotropic effects apart from their lipid-lowering properties. Herein, we investigated the direct effects of atorvastatin on gastric smooth muscle tone. Atorvastatin effectively relaxed isolated rat gastric fundus strips precontracted with acetylcholine, potassium chloride, and serotonin. Incubation of the strips with nitric oxide synthase inhibitor, l-NOARG (10−4 M, 20 min), l-type voltage-operated Ca2+ channel (VOCC) blocker, nifedipine (10−6 M, 30 min), KATP channel blocker, glibenclamide (10−5 M, 30 min), or precursor of cholesterol, mevalonate (10−2 M, 45 min) did not change the relaxations to atorvastatin. However, pretreatment of fundus strips with atorvastatin (3×10−5–3×10−4 M, 30 min) inhibited the contractions to calcium chloride (10−4–10−1 M), acetylcholine (10–4 M), and caffeine (20 mM) in the calcium-free medium. Moreover, atorvastatin reduced the contractions induced by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (10−7–3×10−5 M). The current study demonstrated that atorvastatin produces an acute relaxant effect on gastric fundus strips, which appears to be mediated by several Ca2+-signalling mechanisms such as the blockade of l-type VOCC-independent Ca2+ entry, decrease in smooth muscle Ca2+ sensitivity, inhibition of IP3- and ryanodine-sensitive intracellular stores to mediate Ca2+ release, as well as the activation of SERCA. This acute relaxing effect seems unlikely to be related with nitric oxide, KATP channels, and the mevalonate pathway.

Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle

2004 ◽  
Vol 67 (6) ◽  
pp. 1203-1214 ◽  
Author(s):  
Karel Chalupsky ◽  
Irina Lobysheva ◽  
Françoise Nepveu ◽  
Irina Gadea ◽  
Petra Beranova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Rat Aorta ◽  
Relaxant Effect ◽  
No Formation ◽  
Oxime Derivatives ◽  
Isolated Rat

Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum

2015 ◽  
Vol 172 ◽  
pp. 1-9 ◽  
Author(s):  
Njiaza Joseph ◽  
Ngo Lemba Tom Esther ◽  
Nguelefack Télesphore Benoît ◽  
Dzeufiet Djomeni Paul Désiré ◽  
Aboubakar Oumarou Bibi-Farouck ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Contractile Activity ◽  
Rat Duodenum ◽  
Isolated Rat
Sign in / Sign up

Export Citation Format

Share Document