scholarly journals Impact of Mediterranean Diet on Disease Activity and Gut Microbiota Composition of Rheumatoid Arthritis Patients

2020 ◽  
Vol 8 (12) ◽  
pp. 1989
Author(s):  
Andrea Picchianti Diamanti ◽  
Concetta Panebianco ◽  
Gerardo Salerno ◽  
Roberta Di Rosa ◽  
Simonetta Salemi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Disease Activity ◽  
Mediterranean Diet ◽  
Inverse Association ◽  
Microbiota Composition ◽  
High Adherence ◽  
The Mediterranean ◽  
Adherence Group ◽  
Gut Microbiota Composition

Rheumatoid arthritis (RA) is an autoimmune disorder in which gut and oral microbiota play a crucial role. Diet is a modifiable factor that can influence both microbiota composition and arthritis outcome; previous studies have suggested associations between dietary habits and RA, with contrasting results. We investigate the protective effect of the Mediterranean diet (MD) on disease activity and the gut microbiota profile in RA patients. Sixty consecutive RA patients were enrolled upon filling a validated 14-item questionnaire for the assessment of adherence to the Mediterranean diet (Prevention with Mediterranean Diet-PREDIMED). Then, 16S analysis was employed to explore the gut microbiota within the two cohorts of patients. Patients with high adherence to MD (20) had a significantly lower C-reactive protein (p < 0.037) and disease activity (p < 0.034) than the 40 patients with low/moderate adherence to MD. An inverse association between MD and disease activity was confirmed by multivariate analysis after adjustments for all the different demographic, clinical and serologic variables. A healthier gut microbiota composition was observed in the high adherence group, with a significant decrease in Lactobacillaceae and an almost complete absence of Prevotella copri with respect to the low/moderate adherence group. In conclusion, our findings support the protective role of MD on disease activity and microbiota composition in RA patients, and suggest the feasibility of shifting the habitual diet to modulate the gut microbiota and promote the benefits associated with MD.

scholarly journals Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 748 ◽  
Author(s):  
Jin-Young Lee ◽  
Mohamed Mannaa ◽  
Yunkyung Kim ◽  
Jehun Kim ◽  
Geun-Tae Kim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Amplicon Sequencing ◽  
Fecal Microbiota ◽  
Rrna Gene ◽  
Microbiota Composition ◽  
Stool Samples ◽  
Gut Microbiota Composition

The aim of this study was to investigate differences between the gut microbiota composition in patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA). Stool samples from nine RA patients and nine OA patients were collected, and DNA was extracted. The gut microbiome was assessed using 16S rRNA gene amplicon sequencing. The structures and differences in the gut microbiome between RA and OA were analyzed. The analysis of diversity revealed no differences in the complexity of samples. The RA group had a lower Bacteroidetes: Firmicutes ratio than did the OA group. Lactobacilli and Prevotella, particularly Prevotella copri, were more abundant in the RA than in the OA group, although these differences were not statistically significant. The relative abundance of Bacteroides and Bifidobacterium was lower in the RA group. At the species level, the abundance of certain bacterial species was significantly lower in the RA group, such as Fusicatenibacter saccharivorans, Dialister invisus, Clostridium leptum, Ruthenibacterium lactatiformans, Anaerotruncus colihominis, Bacteroides faecichinchillae, Harryflintia acetispora, Bacteroides acidifaciens, and Christensenella minuta. The microbial properties of the gut differed between RA and OA patients, and the RA dysbiosis revealed results similar to those of other autoimmune diseases, suggesting that a specific gut microbiota pattern is related to autoimmunity.

scholarly journals Adherence to the Mediterranean diet is associated with the gut microbiota pattern and gastrointestinal characteristics in an adult population

2017 ◽  
Vol 117 (12) ◽  
pp. 1645-1655 ◽  
Author(s):  
Evdokia K. Mitsou ◽  
Aimilia Kakali ◽  
Smaragdi Antonopoulou ◽  
Konstantinos C. Mountzouris ◽  
Mary Yannakoulia ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Dietary Habits ◽  
Adult Population ◽  
Gastrointestinal Symptoms ◽  
Molar Ratio ◽  
Plate Count ◽  
E Coli ◽  
High Adherence ◽  
The Mediterranean

AbstractThis study aimed to explore the potential associations of adherence to the Mediterranean diet with gut microbiota characteristics and gastrointestinal symptomatology in an adult population. Other long-term dietary habits (e.g. consumption of snacks and junk food or stimulant intake) were also evaluated in terms of the gut microbiota profile. Participants (n 120) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Adherence to the Mediterranean diet was assessed using a Mediterranean diet score, the MedDietScore, and subjects were classified into three tertiles according to individual adherence scoring. Gut microbiota composition was determined using quantitative PCR and plate-count techniques, and faecal SCFA were analysed using GC. Gastrointestinal symptoms were also evaluated. Participants with a high adherence to the Mediterranean diet had lower Escherichia coli counts (P=0·022), a higher bifidobacteria:E. coli ratio (P=0·025), increased levels and prevalence of Candida albicans (P=0·039 and P=0·050, respectively), greater molar ratio of acetate (P=0·009), higher defaecation frequency (P=0·028) and a more pronounced gastrointestinal symptomatology compared with those reporting low adherence. A lower molar ratio of valerate was also observed in the case of high adherence to the Mediterranean diet compared with the other two tertiles (Pfor trend=0·005). Positive correlations of MedDietScore with gastrointestinal symptoms, faecal moisture, total bacteria, bifidobacteria:E. coli ratio, relative share of Bacteroides, C. albicans and total SCFA, as well as negative associations with cultivable E. coli levels and valerate were indicated. Fast food consumption was characterised by suppressed representation of lactobacilli and butyrate-producing bacteria. In conclusion, our findings support a link between adherence to the Mediterranean diet and gut microbiota characteristics.

Effect of Mediterranean diet versus low caloric diet on rheumatoid arthritis disease activity

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Lobna A Saleh ◽  
Mona A Sebaie ◽  
Heba F El Shishtawy ◽  
Sahar F Ahmed
Keyword(s):  
Rheumatoid Arthritis ◽  
Environmental Factors ◽  
Disease Activity ◽  
Mediterranean Diet ◽  
Low Calorie ◽  
Significant Difference ◽  
Diet Versus ◽  
The Mediterranean ◽  
Group 2 ◽  
Group 1

Abstract Background Rheumatoid arthritis Is a systemic connective tissue disease affecting predominantly joints. The disease develops in a course of autoimmune inflammatory process triggered by environmental factors in genetically predisposed person .One such environmental factors is the diet . A basic explanation of a low calorie diet is described as a diet that provides fewer than 1,200 calories per day. .Low calorie diets are known for getting individuals mind excited about losing the weight without the actual motivation to exercise. The Mediterranean diet is not a single prescribed diet, but rather a general food-based eating pattern, which is marked by local and cultural differences throughout the Mediterranean region.Diet is generally characterized by a high intake of plant-based foods (e.g. fresh fruit and vegetables, nuts, and cereals) and olive oil. Also it is characterized by moderate intake of fish and poultry, and low intakes of dairy products (mostly yoghurt and cheese), red and processed meats, and sweets. Objectives To assess the effect of Mediterranean diet versus low caloric diet on disease activity of rheumatoid arthritis Patient and methods The present study included 30 patients with Rheumatoid Arthritis diagnosed according to 2010 ACR\EULAR criteria every patient is subjected to full clinical examination ;BMI DAS28, CDAI, laboratory investigations, ESR, CRP, CBC, lipid profile, ALT, AST and serum creatinine. Patients were randomly assigned into one of two groups ; group 1 included 15 patients who received low caloric diet and group 2 included 15 patients who received Mediterranean diet for 6 weeks to be reassessed at the end of study. Results Both groups ;low caloric diet group and Mediterranean diet had significant improvement on BMI, number of tender joints, DAS and CDAI mHAQ, ESR CRP,TC p &lt; 0.05 There was non significant change between both groups as regard previously mentioned parameters however regarding percent of change between both groups. There was significant difference regarding only BMI with more reduction in group 2 versus group 1 Conclusion both regimens are effective in lowering RA activity. Both have positive impacts on quality of life of RA patients,

scholarly journals SAT0090 GUT MICROBIOTA COMPOSITION IS CONTINGENT WITH DISEASE PHASES IN RHEUMATOID ARTHRITIS

2019 ◽  
Author(s):  
Elisa Gremese ◽  
Francesco Cianci ◽  
Stefano Alivernini ◽  
Giulia Menchinelli ◽  
Anna Laura Fedele ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

scholarly journals Influence of Mediterranean Diet on Human Gut Microbiota

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 7
Author(s):  
Giuseppe Merra ◽  
Annalisa Noce ◽  
Giulia Marrone ◽  
Marco Cintoni ◽  
Maria Grazia Tarsitano ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Intervention Studies ◽  
Microbiota Composition ◽  
Human Gut ◽  
Human Microbiota ◽  
All Cause Mortality ◽  
Metabolic Endotoxemia ◽  
Gut Microbiota Composition ◽  
Diet Model

Gut microbiota changes correlate with health status. Literature data on gut microbiota show that all dietary changes can induce the alteration of gut microbiota composition. Mediterranean diet (MD) is associated with a reduction of all-cause mortality and in this review, we analyzed its interactions with human microbiota. In particular, we explored the modulation of the human microbiota, in response to MD adherence, focusing the attention on polyphenols, polyunsaturated fatty acids (PUFA) ω-3 and fiber. Evidences suggest that MD is able to modulate the gut microbiota, increasing its diversity. In fact, a Mediterranean-type dietary pattern is associated with specific gut microbiota characteristics. The available evidence, suggests that gut microbiota of subjects that follow a MD is significantly different from subjects that follow a Western diet model. In fact, the latter show an increased gut permeability, which is responsible for metabolic endotoxemia. For this reason, we can speculate that the gut microbiota of the subjects following a MD is able to prevent the onset of chronic non-communicable degenerative diseases, such as cardiovascular diseases and some types of cancer. However, in order to understand these correlations with dietary patterns, controlled intervention studies on the gut microbiota composition and activity are needed.

scholarly journals Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept

2018 ◽  
Vol 19 (10) ◽  
pp. 2938 ◽  
Author(s):  
Andrea Picchianti-Diamanti ◽  
Concetta Panebianco ◽  
Simonetta Salemi ◽  
Maria Sorgi ◽  
Roberta Di Rosa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Disease Activity ◽  
Immunosuppressive Drugs ◽  
Clinical Parameters ◽  
Healthy Controls ◽  
Microbiota Composition ◽  
Necrosis Factor Alpha ◽  
Partial Restoration ◽  
Gut Dysbiosis

A certain number of studies were carried out to address the question of how dysbiosis could affect the onset and development of rheumatoid arthritis (RA), but little is known about the reciprocal influence between microbiota composition and immunosuppressive drugs, and how this interaction may have an impact on the clinical outcome. The aim of this study was to characterize the intestinal microbiota in a groups of RA patients treatment-naïve, under methotrexate, and/or etanercept (ETN). Correlations between the gut microbiota composition and validated immunological and clinical parameters of disease activity were also evaluated. In the current study, a 16S analysis was employed to explore the gut microbiota of 42 patients affected by RA and 10 healthy controls. Disease activity score on 28 joints (DAS-28), erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptides, and dietary and smoking habits were assessed. The composition of the gut microbiota in RA patients free of therapy is characterized by several abnormalities compared to healthy controls. Gut dysbiosis in RA patients is associated with different serological and clinical parameters; in particular, the phylum of Euryarchaeota was directly correlated to DAS and emerged as an independent risk factor. Patients under treatment with ETN present a partial restoration of a beneficial microbiota. The results of our study confirm that gut dysbiosis is a hallmark of the disease, and shows, for the first time, that the anti-tumor necrosis factor alpha (TNF-α) ETN is able to modify microbial communities, at least partially restoring a beneficial microbiota.

Sign in / Sign up

Export Citation Format

Share Document