scholarly journals Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator

Micromachines ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 274 ◽  
Author(s):  
Zihao Li ◽  
Chenggang Zhu ◽  
Zhihe Guo ◽  
Bowen Wang ◽  
Xiang Wu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Label Free ◽  
Highly Sensitive ◽  
Label Free Detection

Gold nanoparticle integrated artificial nanochannels for label-free detection of peroxynitrite

2021 ◽  
Author(s):  
Jing Wu ◽  
Xing Wang ◽  
Lei Ge ◽  
Rui Lv ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Small Molecules ◽  
Gold Nanoparticle ◽  
Sensitive Detection ◽  
Label Free ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Highly Sensitive Detection

A label-free method for rapid and highly sensitive detection of ONOO− was proposed by employing ABEI@AuNPs integrated nanochannels. This work paves a new way to develop a versatile platform for the detection of different biological small molecules.

Target-induced structure switching of DNA for label-free and ultrasensitive electrochemiluminescent detection of proteins

2014 ◽  
Vol 50 (24) ◽  
pp. 3211-3213 ◽  
Author(s):  
Mengli Yang ◽  
Ying Chen ◽  
Yun Xiang ◽  
Ruo Yuan ◽  
Yaqin Chai
Keyword(s):  
Dna Structure ◽  
Label Free ◽  
Switching Strategy ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Exo Iii ◽  
Recycling Amplification ◽  
Structure Switching ◽  
Induced Structure

Highly sensitive and label-free detection of thrombin is achieved via a target-induced DNA structure switching strategy and Exo III-assisted recycling amplification.

scholarly journals A Simple Displacement Aptamer Assay on Resistive Pulse Sensor for Small Molecule Detection

2020 ◽  
Author(s):  
Rhushabh Maugi ◽  
bernadette gamble ◽  
david bunka ◽  
Mark Platt
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Label Free ◽  
Resistive Pulse ◽  
Pulse Sensor ◽  
Label Free Detection ◽  
Ssdna Aptamer ◽  
Aptamer Assay ◽  
Small Molecule Detection ◽  
Surface Changes

A universal aptamer-based sensing strategy is proposed using DNA modified nanocarriers and Resistive Pulse Sensing for the rapid and label free detection of small molecules. The surface of a magnetic nanocarrier was first modified with a ssDNA aka linker which is designed to be partially complimentary in sequence to a ssDNA aptamer. The aptamer and linker form a stable dsDNA complex on the nanocarriers surface. Upon the addition of the target molecule, a conformational change takes place where the aptamer preferentially binds to the target over the linker; causing the aptamer to be released into solution. The RPS measures the change in velocity of the nanocarrier as its surface changes from dsDNA to ssDNA, and its velocity is used as a proxy for the concentration of the target. We illustrate the versatility of the assay by demonstrating the detection of the antibiotic Moxifloxacin, and chemotherapeutics Imatinib and Irinotecan.

scholarly journals Paper-based fluorogenic RNA aptamer sensors for label-free detection of small molecules

2020 ◽  
Vol 12 (21) ◽  
pp. 2674-2681
Author(s):  
Fatemeh Shafiei ◽  
Kathleen McAuliffe ◽  
Yousef Bagheri ◽  
Zhining Sun ◽  
Qikun Yu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Rapid Detection ◽  
Rna Aptamer ◽  
Label Free ◽  
Target Analytes ◽  
Label Free Detection

A paper-based portable fluorogenic RNA sensor for the selective, sensitive, and rapid detection of target analytes.

scholarly journals Chiral Plasmonic Biosensors

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 120 ◽  
Author(s):  
Vladimir Bochenkov ◽  
Tatyana Shabatina
Keyword(s):  
Refractive Index ◽  
Surface Plasmon Resonance ◽  
Plasmonic Nanostructures ◽  
Label Free ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Recent Developments ◽  
Detection Of Biomolecules ◽  
Local Refractive Index ◽  
Unique Capability

Biosensing requires fast, selective, and highly sensitive real-time detection of biomolecules using efficient simple-to-use techniques. Due to a unique capability to focus light at nanoscale, plasmonic nanostructures provide an excellent platform for label-free detection of molecular adsorption by sensing tiny changes in the local refractive index or by enhancing the light-induced processes in adjacent biomolecules. This review discusses the opportunities provided by surface plasmon resonance in probing the chirality of biomolecules as well as their conformations and orientations. Various types of chiral plasmonic nanostructures and the most recent developments in the field of chiral plasmonics related to biosensing are considered.

scholarly journals Optical Biosensors for Label-Free Detection of Small Molecules

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4126 ◽  
Author(s):  
Riikka Peltomaa ◽  
Bettina Glahn-Martínez ◽  
Elena Benito-Peña ◽  
María Moreno-Bondi
Keyword(s):  
Small Molecules ◽  
High Sensitivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
Optical Biosensors ◽  
Label Free ◽  
Fiber Sensors ◽  
Label Free Detection ◽  
Surface Enhanced Raman ◽  
Resonance Surface ◽  
Small Molecule Detection

Label-free optical biosensors are an intriguing option for the analyses of many analytes, as they offer several advantages such as high sensitivity, direct and real-time measurement in addition to multiplexing capabilities. However, development of label-free optical biosensors for small molecules can be challenging as most of them are not naturally chromogenic or fluorescent, and in some cases, the sensor response is related to the size of the analyte. To overcome some of the limitations associated with the analysis of biologically, pharmacologically, or environmentally relevant compounds of low molecular weight, recent advances in the field have improved the detection of these analytes using outstanding methodology, instrumentation, recognition elements, or immobilization strategies. In this review, we aim to introduce some of the latest developments in the field of label-free optical biosensors with the focus on applications with novel innovations to overcome the challenges related to small molecule detection. Optical label-free methods with different transduction schemes, including evanescent wave and optical fiber sensors, surface plasmon resonance, surface-enhanced Raman spectroscopy, and interferometry, using various biorecognition elements, such as antibodies, aptamers, enzymes, and bioinspired molecularly imprinted polymers, are reviewed.

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