scholarly journals Highly Sensitive Detection for Mercury Ions Using Graphene Oxide (GO) Sensors

Micromachines ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1070
Author(s):  
Lei Liu ◽  
Haixia Shi ◽  
Raoqi Li ◽  
Cheng Liu ◽  
Jia Cheng ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Fluorescent Dyes ◽  
Limit Of Detection ◽  
Sybr Green ◽  
Sybr Green I ◽  
Mercury Ions ◽  
Amino Groups ◽  
Highly Sensitive ◽  
Detection Of Signals ◽  
Highly Sensitive Detection

The mercury ion (Hg2+) is one of the heavy metal ions, and its presence in trace amounts can cause physiological damage to an organism. Traditional methods of Hg2+ detection have been useful but have also had numerous limitations and challenges, and as a result, it is important to design new and sophisticated methods that can aid in the detection of Hg2+. In this paper, two fluorescent dyes, carboxyfluorescein (FAM) and SYBR Green I, were used to label and intercalate DNA probes immobilized on the surface of graphene oxide (GO) for sensors to detect Hg2+. FAM and SYBR Green I dye share close excitation and emission wavelength spectra, which can promote and amplify the detection of signals, and also increase the limit of detection (LOD). The results showed that the limit of detection in this method was 0.53 nM. Moreover, when the sensors with double amino groups on the surface of GO were carried out to detect Hg2+, a limit of detection was improved to 0.43 nM. The sensors were then applied in the real sample. The results show that this method has a promising potential in Hg2+ detection.

scholarly journals Detection of Mercury Ion with High Sensitivity and Selectivity Using a DNA/Graphene Oxide Hybrid Immobilized on Glass Slides

Biosensors ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 300
Author(s):  
Li Gao ◽  
Qiuxiang Lv ◽  
Ni Xia ◽  
Yuanwei Lin ◽  
Feng Lin ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
High Selectivity ◽  
Limit Of Detection ◽  
Low Cost ◽  
High Sensitivity ◽  
Mercury Ions ◽  
Research Areas ◽  
Glass Slides ◽  
Highly Sensitive ◽  
Sensitivity And Selectivity

Excessive mercury ions (Hg2+) cause great pollution to soil/water and pose a major threat to human health. The high sensitivity and high selectivity in the Hg2+ detection demonstrated herein are significant for the research areas of analytical chemistry, chemical biology, physical chemistry, drug discovery, and clinical diagnosis. In this study, a series of simple, low-cost, and highly sensitive biochips based on a graphene oxide (GO)/DNA hybrid was developed. Hg2+ is detected with high sensitivity and selectivity by GO/DNA hybrid biochips immobilized on glass slides. The performance of the biosensors can be improved by introducing more phosphorothioate sites and complementary bases. The best limit of detection of the biochips is 0.38 nM with selectivity of over 10:1. This sensor was also used for Hg2+ detection in Dendrobium. The results show this biochip is promising for Hg2+ detection.

scholarly journals Highly Sensitive Electrochemical Biosensor Using Folic Acid-Modified Reduced Graphene Oxide for the Detection of Cancer Biomarker

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1272
Author(s):  
Renu Geetha Bai ◽  
Kasturi Muthoosamy ◽  
Rando Tuvikene ◽  
Huang Nay Ming ◽  
Sivakumar Manickam
Keyword(s):  
Graphene Oxide ◽  
Folic Acid ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Great Promise ◽  
Sensing Applications ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

The detection of cancer biomarkers in the early stages could prevent cancer-related deaths significantly. Nanomaterials combined with biomolecules are extensively used in drug delivery, imaging, and sensing applications by targeting the overexpressed cancer proteins such as folate receptors (FRs) to control the disease by providing earlier treatments. In this investigation, biocompatible reduced graphene oxide (rGO) nanosheets combined with folic acid (FA)-a vitamin with high bioaffinity to FRs-is utilized to develop an electrochemical sensor for cancer detection. To mimic the cancer cell environment, FR-β protein is used to evaluate the response of the rGO-FA sensor. The formation of the rGO-FA nanocomposite was confirmed through various characterization techniques. A glassy carbon (GC) electrode was then modified with the obtained rGO-FA and analyzed via differential pulse voltammetry (DPV) for its specific detection towards FRs. Using the DPV technique, the rGO-FA-modified electrode exhibited a limit of detection (LOD) of 1.69 pM, determined in a linear concentration range from 6 to 100 pM. This excellent electrochemical performance towards FRs detection could provide a significant contribution towards future cancer diagnosis. Moreover, the rGO-FA sensing platform also showed excellent specificity and reliability when tested against similar interfering biomolecules. This rGO-FA sensor offers a great promise to the future medical industry through its highly sensitive detection towards FRs in a fast, reliable, and economical way.

Highly sensitive detection of hesperidin using AuNPs/rGO modified glassy carbon electrode

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 297-303 ◽  
Author(s):  
Yang Gao ◽  
Xiufeng Wu ◽  
Hui Wang ◽  
Wenbo Lu ◽  
Mandong Guo
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Electrochemical Sensor ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

The highly sensitive and selective electrochemical sensor of hesperidin based on gold nanoparticles (AuNPs) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE) is reported.

Highly sensitive and selective detection of silver(i) in aqueous solution with silver(i)-specific DNA and Sybr green I

The Analyst ◽  
2013 ◽  
Vol 138 (7) ◽  
pp. 2057 ◽  
Author(s):  
Qing Yang ◽  
Fan Li ◽  
Yan Huang ◽  
Hui Xu ◽  
Linsheng Tang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Sybr Green ◽  
Sybr Green I ◽  
Selective Detection ◽  
Highly Sensitive

Highly Sensitive Detection of Mercury Ions Using Zincophosphite Framework Nanoparticle–Polyaniline Composites

2020 ◽  
Vol 3 (10) ◽  
pp. 9724-9730 ◽  
Author(s):  
Ying Li ◽  
Ji-Fang Xie ◽  
Chiao-Chun Chang ◽  
Chih-Min Wang ◽  
Hsiung-Lin Tu
Keyword(s):  
Sensitive Detection ◽  
Mercury Ions ◽  
Highly Sensitive ◽  
Polyaniline Composites ◽  
Highly Sensitive Detection

Ultrasensitive electrochemical detection of Hg2+based on an Hg2+-triggered exonuclease III-assisted target recycling strategy

The Analyst ◽  
2018 ◽  
Vol 143 (23) ◽  
pp. 5771-5778 ◽  
Author(s):  
Xiaolei Song ◽  
Yu Wang ◽  
Su Liu ◽  
Xue Zhang ◽  
Haiwang Wang ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Electrochemical Method ◽  
Sensitive Detection ◽  
Mercury Ions ◽  
Exonuclease Iii ◽  
Target Recycling ◽  
Highly Sensitive ◽  
Recycling Amplification ◽  
Highly Sensitive Detection

An isothermal electrochemical method for the highly sensitive detection of mercury ions (Hg2+) was established based on Hg2+-triggered exonuclease III-aided target recycling amplification.

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