scholarly journals A Microfluidic Mixer of High Throughput Fabricated in Glass Using Femtosecond Laser Micromachining Combined with Glass Bonding

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 213 ◽  
Author(s):  
Jia Qi ◽  
Wenbo Li ◽  
Wei Chu ◽  
Jianping Yu ◽  
Miao Wu ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Fused Silica ◽  
Wet Etching ◽  
Mixing Efficiency ◽  
Cross Sectional ◽  
Microfluidic Mixer ◽  
Silica Substrate ◽  
Femtosecond Laser Micromachining ◽  
Bonding Method

We demonstrate a microfluidic mixer of high mixing efficiency in fused silica substrate using femtosecond laser-induced wet etching and hydroxide-catalysis bonding method. The micromixer has a three-dimensional geometry, enabling efficient mixing based on Baker’s transformation principle. The cross-sectional area of the fabricated micromixer was 0.5 × 0.5 mm2, enabling significantly promotion of the throughput of the micromixer. The performance of the fabricated micromixers was evaluated by mixing up blue and yellow ink solutions with a flow rate as high as 6 mL/min.

scholarly journals A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

2021 ◽  
Vol 11 (8) ◽  
pp. 3404
Author(s):  
Majid Hejazian ◽  
Eugeniu Balaur ◽  
Brian Abbey
Keyword(s):  
Molecular Dynamics ◽  
Flow Rate ◽  
Numerical Study ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Liquid Jets ◽  
Mixing Efficiency ◽  
X Ray Diffraction ◽  
Cross Sectional ◽  
Time Required

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

Monolithic Three-Dimensional Integration of Micro-Fluidic Channels and Optical Waveguides in Fused Silica

2003 ◽  
Vol 782 ◽  
Author(s):  
Yves Bellouard ◽  
Ali Said ◽  
Mark Dugan ◽  
Philippe Bado
Keyword(s):  
Optical Waveguides ◽  
Single Channel ◽  
Three Dimensional ◽  
Fused Silica ◽  
Microfluidic Channels ◽  
Major Step ◽  
Micro Fabrication ◽  
Silica Substrate ◽  
Massively Parallel Processing ◽  
Integrated Device

ABSTRACTThis paper presents dramatic improvements in the micro-fabrication of three-dimensional microfluidic channels and high-aspect ratio tunnels within the bulk of a fused silica substrate. We also report the fabrication of optical waveguides within the same substrate, which is a major step towards the integration of sensing capabilities within microfluidic networks.This integrated device, which combines both fluidic channels and optical waveguides, opens new opportunities in bio- and chemical sensing. The flexibility of the improved manufacturing process offers substantial new design capabilities, especially for single channel probing and massively parallel processing and sensing.

Fabrication of three-dimensional micro-Rogowski coil based on femtosecond laser micromachining

2015 ◽  
Vol 120 (2) ◽  
pp. 669-674 ◽  
Author(s):  
Xiangwei Meng ◽  
Qing Yang ◽  
Feng Chen ◽  
Chao Shan ◽  
Keyin Liu ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Laser Micromachining ◽  
Rogowski Coil ◽  
Femtosecond Laser Micromachining

Femtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass

Lab on a Chip ◽  
2014 ◽  
Vol 14 (18) ◽  
pp. 3447-3458 ◽  
Author(s):  
Koji Sugioka ◽  
Jian Xu ◽  
Dong Wu ◽  
Yasutaka Hanada ◽  
Zhongke Wang ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Laser Micromachining ◽  
Femtosecond Laser Micromachining

Femtosecond laser micromachining can directly fabricate three-dimensional (3D) microfluidic devices integrated with functional microcomponents in glass microchips.

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