scholarly journals A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics

Micromachines ◽  
2019 ◽  
Vol 10 (5) ◽  
pp. 291 ◽  
Author(s):  
Zehang Gao ◽  
Huo Peng ◽  
Minjie Zhu ◽  
Lei Wu ◽  
Chunping Jia ◽  
...  

In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidics. In this paper, the principle, setup and procedure were introduced. Finally, as a demonstration, the strategy was also implemented in a miniaturized picoinjector in order to monitor and control the injection dosage to droplets. We expect that this facile strategy supplies a low-cost yet effective imaging system that can be easily implemented in miniaturized microfluidic systems or general laboratories.

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Dongju Chen ◽  
Shuai Zhou ◽  
Lihua Dong ◽  
Jinwei Fan

This paper presents a new identification method to identify the main errors of the machine tool in time-frequency domain. The low- and high-frequency signals of the workpiece surface are decomposed based on the Daubechies wavelet transform. With power spectral density analysis, the main features of the high-frequency signal corresponding to the imbalance of the spindle system are extracted from the surface topography of the workpiece in the frequency domain. With the cross-correlation analysis method, the relationship between the guideway error of the machine tool and the low-frequency signal of the surface topography is calculated in the time domain.


2014 ◽  
Vol 989-994 ◽  
pp. 3973-3976
Author(s):  
Yi Fan Ma ◽  
Shu Gui Liu

Image edge detection is easily affected by noise. Wavelet algorithm can divide the image into low frequency and high frequency. By the processing of high frequency signal and the reconstruction of wavelet coefficients, the purpose of removing noise can be achieved. In the environment of VC++6.0, an image de-noising algorithm based on the wavelet combined with the Canny edge detection is proposed, which obtains a good result. The above algorithms are implemented based on OpenCV, which is more efficient, providing the conditions for subsequent image analysis and recognition. Experiments are carried out and the results show that the proposed algorithm is available and has a good performance.


2006 ◽  
Vol 129 (2) ◽  
pp. 194-202 ◽  
Author(s):  
Peter C. Hung ◽  
Robert J. Kee ◽  
George W. Irwin ◽  
Seán F. McLoone

Thermocouples are one of the most popular devices for temperature measurement due to their robustness, ease of manufacture and installation, and low cost. However, when used in the harsh environment found in combustion systems and automotive engine exhausts, large wire diameters are required and consequently the measurement bandwidth is reduced. This paper describes two new algorithmic compensation techniques based on blind deconvolution to address this loss of high-frequency signal components using the measurements from two thermocouples. In particular, a continuous-time approach is proposed, combined with a cross-relation blind deconvolution for parameter estimation. A feature of this approach is that no a priori assumption is made about the time constant ratio of the two thermocouples. The advantages, including small estimation variance and limitations of the method, are highlighted using results from simulation and test rig studies.


2014 ◽  
Vol 28 (16) ◽  
pp. 1450103 ◽  
Author(s):  
Canjun Wang ◽  
Keli Yang ◽  
Shixian Qu

The effects of time delay on the vibrational resonance (VR) in a discrete neuron system with a low-frequency signal and a high-frequency signal are investigated by numerical simulations. The results show that there exists a delay time that optimizes the phase synchronization between the low-frequency input signal and the output signal. VR is induced by the time delay. Furthermore, the time delay can improve the response to a low-frequency input signal. Therefore, the time delay plays a constructive role in the transmission of a low-frequency signal by inducing and enhancing VR.


2014 ◽  
Vol 543-547 ◽  
pp. 514-517
Author(s):  
Hong Bo Li ◽  
Lin Niu ◽  
Nan Nan Gao ◽  
Jie Zhan ◽  
Pei Li ◽  
...  

By analyzing the two lightning accidents happening to a 500kV substation situated in the lightning-prone northeastern Guangdong Province, I conclude as follows, there should be some problem in the equipotential earthing of the secondary system of this substation. Specifically, the existing potential difference in the secondary equipment gave rise to the meltdown of it which finally caused the accident. In the context,I build the one-point earthing parallel system simulation model according to ATP graphic pretreatment program, then by using slope-ramp simulation I study the lightning current which leaked into the grounding grids of the substation.In conclusion, the application of high frequency signal mixed low frequency signal earth system in the secondary system and the equipotential bonding is key to preventing accidents.


2018 ◽  
Author(s):  
Juan L.P. Soto ◽  
Felipe V.D. Prado ◽  
Etienne Combrisson ◽  
Karim Jerbi

AbstractMany functional connectivity studies based on electrophysiological measurements, such as electro- and magnetoencephalography (EEG/MEG), start their investigations by extracting a narrowband representation of brain activity time series, and then computing their envelope amplitudes and instantaneous phases, which serve as inputs to subsequent data processing. The two most popular approaches for obtaining these narrowband amplitudes and phases are: bandpass filtering followed by Hilbert transform (we call this the Hilbert approach); and convolution with wavelet kernels (the wavelet approach). In this work, we investigate how these two approaches perform in detecting the phenomenon of phase-amplitude coupling (PAC), whereby the amplitude of a high-frequency signal is driven by the phase of a low-frequency signal. The comparison of both approaches is carried out by means of simulated brain activity, from which we run receiver operating characteristic (ROC) analyses, and of experimental MEG data from a visuomotor coordination study. The ROC analyses show that both approaches have comparable accuracy, except in the presence of interfering signals with frequencies near the high-frequency band. As for the visuomotor data, the most noticeable impact of the choice of approach was observed when evaluating task-based changes in PAC between the delta (2-5 Hz) and the high-gamma (60-90 Hz) frequency bands, as we were able to identify widespread brain areas with statistically significant effects only with the Hilbert approach. These results provide preliminary evidence of the advantages of the Hilbert approach over the wavelet approach, at least in the context of PAC estimates.


2019 ◽  
Vol 219 (2) ◽  
pp. 1082-1091 ◽  
Author(s):  
Johno van IJsseldijk ◽  
Elmer Ruigrok ◽  
Arie Verdel ◽  
Cornelis Weemstra

SUMMARY Global phases, viz. seismic phases that travel through the Earth’s core, can be used to locally image the crust by means of seismic interferometry. This method is known as Global Phase Seismic Interferometry (GloPSI). Traditionally, GloPSI retrieves low-frequency information (up to 1 Hz). Recent studies, however, suggest that there is high-frequency signal present in the coda of strong, distant earthquakes. This research quantifies the potential of these high-frequency signals, by analysing recordings of a multitude of high-magnitude earthquakes (≥6.4 Mw) and their coda on a selection of permanent USArray stations. Nearly half of the P, PKP and PKIKP phases are recorded with a signal-to-noise ratio of at least 5 dB at 3 Hz. To assess the viability of using the high-frequency signal, the second half of the paper highlights two case studies. First, a known sedimentary structure is imaged in Malargüe, Argentina. Secondly, the method is used to reveal the structure of the Midcontinent Rift below the SPREE array in Minnesota, USA. Both studies demonstrate that structural information of the shallow crust (≤5 km) below the arrays can be retrieved. In particular, the interpreted thickness of the sedimentary layer below the Malargüe array is in agreement with earlier studies in the same area. Being able to use global phases and direct P-phases with large epicentral distances (>80°) to recover the Earth’s sedimentary structure suggests that GloPSI can be applied in an industrial context.


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