scholarly journals Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device

Micromachines ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 92 ◽  
Author(s):  
Alinaghi Salari ◽  
Colin Dalton
Keyword(s):  
Cross Section ◽  
Fluid Transport ◽  
Biological Fluids ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Channel Cross Section ◽  
Mixing Efficiency ◽  
Electrode Pair ◽  
Transverse Mixing ◽  
Double Array

Transport and mixing of minute amounts of biological fluids are significantly important in lab-on-a-chip devices. It has been shown that the electrothermal technique is a suitable candidate for applications involving high-conductivity biofluids, such as blood, saliva, and urine. Here, we introduce a double-array AC electrothermal (ACET) device consisting of two opposing microelectrode arrays, which can be used for simultaneous mixing and pumping. First, in a 2D simulation, an optimum electrode-pair configuration capable of achieving fast transverse mixing at a microfluidic channel cross-section is identified by comparing different electrode geometries. The results show that by adjusting the applied voltage pattern and position of the asymmetrical microelectrodes in the two arrays, due to the resultant circular flow streamlines, the time it takes for the analytes to be convected across the channel cross-section is reduced by 95% compared to a diffusion-only-based transport regime, and by 80% compared to a conventional two-layer ACET device. Using a 3D simulation, the fluid transport (pumping and mixing) capabilities of such an electrode pair placed at different angles longitudinally relative to the channel was studied. It was found that an asymmetrical electrode configuration placed at an angle in the range of 30 ° ≤ θ ≤ 45 ° can significantly increase transversal mixing efficiency while generating strong longitudinal net flow. These findings are of interest for lab-on-a-chip applications, especially for biosensors and immunoassays, where mixing analyte solutions while simultaneously moving them through a microchannel can greatly enhance the sensing efficiency.

Lubrication theory for electro-osmotic flow in a microfluidic channel of slowly varying cross-section and wall charge

2002 ◽  
Vol 459 ◽  
pp. 103-128 ◽  
Author(s):  
SANDIP GHOSAL
Keyword(s):  
Cross Section ◽  
Microfluidic Channel ◽  
Lubrication Theory ◽  
Wall Material ◽  
Channel Cross Section ◽  
Microfluidic Channels ◽  
Osmotic Flow ◽  
Axial Variation ◽  
Wall Charge ◽  
Electro Osmotic Flow

Electro-osmotic flow is a convenient mechanism for transporting fluid in microfluidic devices. The flow is generated through the application of an external electric field that acts on the free charges that exist in a thin Debye layer at the channel walls. The charge on the wall is due to the particular chemistry of the solid–fluid interface and can vary along the channel either by design or because of various unavoidable inhomogeneities of the wall material or because of contamination of the wall by chemicals contained in the fluid stream. The channel cross-section could also vary in shape and area. The effect of such variability on the flow through microfluidic channels is of interest in the design of devices that use electro-osmotic flow. The problem of electro-osmotic flow in a straight microfluidic channel of arbitrary cross-sectional geometry and distribution of wall charge is solved in the lubrication approximation, which is justified when the characteristic length scales for axial variation of the wall charge and cross-section are both large compared to a characteristic width of the channel. It is thereby shown that the volume flux of fluid through such a microchannel is a linear function of the applied pressure drop and electric potential drop across it, the coefficients of which may be calculated explicitly in terms of the geometry and charge distribution on the wall. These coefficients characterize the ‘fluidic resistance’ of each segment of a microfluidic network in analogy to the electrical ‘resistance’ in a microelectronic circuit. A consequence of the axial variation in channel properties is the appearance of an induced pressure gradient and an associated secondary flow that leads to increased Taylor dispersion limiting the resolution of electrophoretic separations. The lubrication theory presented here offers a simple way of calculating the distortion of the flow profile in general geometries and could be useful in studies of dispersion induced by inhomogeneities in microfluidic channels.

scholarly journals Mapping inertial migration in the cross section of a microfluidic channel with high-speed imaging

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jian Zhou ◽  
Zhangli Peng ◽  
Ian Papautsky
Keyword(s):  
Cross Section ◽  
High Speed ◽  
Microfluidic Channel ◽  
Channel Cross Section ◽  
High Speed Imaging ◽  
Cross Sectional ◽  
Inertial Migration ◽  
Imaging Results ◽  
New Findings ◽  
Migration Pathways

AbstractThe wide adoption of inertial microfluidics in biomedical research and clinical settings, such as rare cell isolation, has prompted the inquiry of its underlying mechanism. Although tremendous improvement has been made, the mechanism of inertial migration remains to be further elucidated. Contradicting observations are not fully reconciled by the existing theory, and details of the inertial migration within channel cross sections are missing in the literature. In this work, for the first time, we mapped the inertial migration pathways within channel cross section using high-speed imaging at the single-particle level. This is in contrast to the conventional method of particle streak velocimetry (PSV), which provides collective information. We also applied smoothed particle hydrodynamics (SPH) to simulate the transient motion of particles in 3D and obtained cross-sectional migration trajectories that are in agreement with the high-speed imaging results. We found two opposing pathways that explain the contradicting observations in rectangular microchannels, and the force analysis of these pathways revealed two metastable positions near the short walls that can transition into stable positions depending on the flow condition and particle size. These new findings significantly improve our understanding of the inertial migration physics, and enhance our ability to precisely control particle and cell behaviors within microchannels for a broad range of applications.

scholarly journals Numerical and Theoretical Study of Performance and Mechanical Behavior of PEM-FC Using Innovative Channel Geometrical Configurations

2021 ◽  
Vol 11 (12) ◽  
pp. 5597
Author(s):  
Hussein A. Z. AL-bonsrulah ◽  
Mohammed J. Alshukri ◽  
Ammar I. Alsabery ◽  
Ishak Hashim
Keyword(s):  
Fuel Cell ◽  
Cross Section ◽  
Rectangular Channel ◽  
Compressive Load ◽  
Proton Exchange ◽  
Channel Cross Section ◽  
Channel Height ◽  
Cross Sectional ◽  
Triangular Channel ◽  
Higher Power

Proton exchange membrane fuel cell (PEM-FC) aggregation pressure causes extensive strains in cell segments. The compression of each segment takes place through the cell modeling method. In addition, a very heterogeneous compressive load is produced because of the recurrent channel rib design of the dipole plates, so that while high strains are provided below the rib, the domain continues in its initial uncompressed case under the ducts approximate to it. This leads to significant spatial variations in thermal and electrical connections and contact resistances (both in rib–GDL and membrane–GDL interfaces). Variations in heat, charge, and mass transfer rates within the GDL can affect the performance of the fuel cell (FC) and its lifetime. In this paper, two scenarios are considered to verify the performance and lifetime of the PEM-FC using different innovative channel geometries. The first scenario is conducted by adopting a constant channel height (H = 1 mm) for all the differently shaped channels studied. In contrast, the second scenario is conducted by taking a constant channel cross-sectional area (A = 1 mm2) for all the studied channels. Therefore, a computational fluid dynamics model (CFD) for a PEM fuel cell is formed through the assembly of FC to simulate the pressure variations inside it. The simulation results showed that a triangular cross-section channel provided the uniformity of the pressure distribution, with lower deformations and lower mechanical stresses. The analysis helped gain insights into the physical mechanisms that lead to the FC’s durability and identify important parameters under different conditions. The model shows that it can assume the intracellular pressure configuration toward durability and appearance containing limited experimental data. The results also proved that the better cell voltage occurs in the case of the rectangular channel cross-section, and therefore, higher power from the FC, although its durability is much lower compared to the durability of the triangular channel. The results also showed that the rectangular channel cross-section gave higher cell voltages, and therefore, higher power (0.63 W) from the fuel cell, although its durability is much lower compared to the durability of the triangular channel. Therefore, the triangular channel gives better performance compared to other innovative channels.

scholarly journals Flexural bearing capacity and failure mechanism of CFRP-aluminum laminate beam with double-channel cross-section

2021 ◽  
Vol 28 (1) ◽  
pp. 139-152
Author(s):  
Teng Huang ◽  
Dongdong Zhang ◽  
Yaxin Huang ◽  
Chengfei Fan ◽  
Yuan Lin ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Bearing Capacity ◽  
Failure Mechanism ◽  
Cross Section ◽  
Failure Criterion ◽  
Failure Modes ◽  
Channel Cross Section ◽  
Fiber Layer ◽  
Flexural Bearing Capacity ◽  
Double Channel

Abstract In this study, the flexural bearing capacity and failure mechanism of carbon fiber-reinforced aluminum laminate (CARALL) beams with a double-channel cross-section and a 3/2 laminated configuration were experimentally and numerically studied. Two types of specimens using different carbon fiber layup configurations ([0°/90°/0°]3 and [45°/0°/−45°]3) were fabricated using the pressure molding thermal curing forming process. The double-channel CARALL beams were subjected to static three-point bending tests to determine their failure behaviors in terms of ultimate bearing capacity and failure modes. Owing to the shortcomings of the two-dimensional Hashin failure criterion, the user-defined FORTRAN subroutine VUMAT suitable for the ABAQUS/Explicit solver and an analysis algorithm were established to obtain a progressive damage prediction of the CFRP layer using the three-dimensional Hashin failure criterion. Various failure behaviors and mechanisms of the CARALL beams were numerically analyzed. The results indicated that the numerical simulation was consistent with the experimental results for the ultimate bearing capacity and final failure modes, and the failure process of the double-channel CARALL beams could be revealed. The ultimate failure modes of both types of double-channel CARALL beams were local buckling deformation at the intersection of the upper flange and web near the concentrated loading position, which was mainly caused by the delamination failure among different unidirectional plates, tension and compression failure of the matrix, and shear failure of the fiber layers. The ability of each fiber layer to resist damage decreased in the order of 90° fiber layer > 0° fiber layer > 45° fiber layer. Thus, it is suggested that 90°, 0°, and 45° fiber layers should be stacked for double-channel CARALL beams.

scholarly journals Fractal-induced 2D flexible net undulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael Joon Seng Goh ◽  
Yeong Shiong Chiew ◽  
Ji Jinn Foo
Keyword(s):  
3D Reconstruction ◽  
Cross Section ◽  
Channel Cross Section ◽  
Time Varying ◽  
Blockage Ratio ◽  
Transient Time ◽  
Cross Sectional ◽  
Velocity Fluctuations ◽  
Square Grid ◽  
Multilength Scale

AbstractA net immersed in fractal-induced turbulence exhibit a transient time-varying deformation. The anisotropic, inhomogeneous square fractal grid (SFG) generated flow interacts with the flexible net to manifest as visible cross-sectional undulations. We hypothesize that the net’s response may provide a surrogate in expressing local turbulent strength. This is analysed as root-mean-squared velocity fluctuations in the net, displaying intensity patterns dependent on the grid conformation and grid-net separation. The net’s fluctuation strength is found to increase closer to the turbulator with higher thickness ratio while presenting stronger fluctuations compared to regular-square-grid (RSG) of equivalent blockage-ratio, σ. Our findings demonstrate a novel application where 3D-reconstruction of submerged nets is used to experimentally contrast the turbulence generated by RSG and multilength scale SFGs across the channel cross-section. The net’s response shows the unique turbulence developed from SFGs can induce 9 × higher average excitation to a net when compared against RSG of similar σ.

Long waves in a straight channel with non-uniform cross-section

2015 ◽  
Vol 770 ◽  
pp. 156-188 ◽  
Author(s):  
Patricio Winckler ◽  
Philip L.-F. Liu
Keyword(s):  
Boundary Layer ◽  
Wave Propagation ◽  
Cross Section ◽  
Three Dimensional ◽  
Channel Cross Section ◽  
Cross Sectional ◽  
New Model ◽  
One Dimensional ◽  
Uniform Channel ◽  
The Cross

A cross-sectionally averaged one-dimensional long-wave model is developed. Three-dimensional equations of motion for inviscid and incompressible fluid are first integrated over a channel cross-section. To express the resulting one-dimensional equations in terms of the cross-sectional-averaged longitudinal velocity and spanwise-averaged free-surface elevation, the characteristic depth and width of the channel cross-section are assumed to be smaller than the typical wavelength, resulting in Boussinesq-type equations. Viscous effects are also considered. The new model is, therefore, adequate for describing weakly nonlinear and weakly dispersive wave propagation along a non-uniform channel with arbitrary cross-section. More specifically, the new model has the following new properties: (i) the arbitrary channel cross-section can be asymmetric with respect to the direction of wave propagation, (ii) the channel cross-section can change appreciably within a wavelength, (iii) the effects of viscosity inside the bottom boundary layer can be considered, and (iv) the three-dimensional flow features can be recovered from the perturbation solutions. Analytical and numerical examples for uniform channels, channels where the cross-sectional geometry changes slowly and channels where the depth and width variation is appreciable within the wavelength scale are discussed to illustrate the validity and capability of the present model. With the consideration of viscous boundary layer effects, the present theory agrees reasonably well with experimental results presented by Chang et al. (J. Fluid Mech., vol. 95, 1979, pp. 401–414) for converging/diverging channels and those of Liu et al. (Coast. Engng, vol. 53, 2006, pp. 181–190) for a uniform channel with a sloping beach. The numerical results for a solitary wave propagating in a channel where the width variation is appreciable within a wavelength are discussed.

Photoionization of Na: Resonance enhancement of the single-channel cross section

1990 ◽  
Vol 42 (3) ◽  
pp. 1286-1292 ◽  
Author(s):  
Alfred Z. Msezane ◽  
William Armstrong-Mensah ◽  
Julian Niles
Keyword(s):  
Cross Section ◽  
Single Channel ◽  
Channel Cross Section ◽  
Resonance Enhancement

scholarly journals Measurement of the single-top-quark t-channel cross section in pp collisions at $ \sqrt{s}=7 $ TeV

2012 ◽  
Vol 2012 (12) ◽  
Author(s):  
S. Chatrchyan ◽  
◽  
V. Khachatryan ◽  
A. M. Sirunyan ◽  
A. Tumasyan ◽  
...  
Keyword(s):  
Cross Section ◽  
Top Quark ◽  
Channel Cross Section ◽  
Pp Collisions ◽  
Single Top
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