scholarly journals Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 337
Author(s):  
Rebecca Kofod Vinding ◽  
Daniela Rago ◽  
Rachel S. Kelly ◽  
Gözde Gürdeniz ◽  
Morten Arendt Rasmussen ◽  
...  
Keyword(s):  
Mental Health ◽  
Fatty Acids ◽  
Cognitive Function ◽  
First Year ◽  
Gross Motor ◽  
Multivariate Modelling ◽  
Fatty Acids Metabolism ◽  
Developmental Index ◽  
First Year Of Life ◽  
Motor Milestone

The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor milestone achievement during infancy by using untargeted plasma metabolomic profiles from 571 six-month-old children in connection with age of motor milestones achievement (Denver Developmental Index) in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort. We used univariate regression models and multivariate modelling (Partial Least Squares Discriminant Analysis: PLS-DA) to examine the associations and the VDAART (Vitamin D Antenatal Asthma Reduction Trial) cohort for validation. The univariate analyses showed 62 metabolites associated with gross-motor milestone achievement (p < 0.05) as well as the PLS-DA significantly differentiated between slow and fast milestone achievers (AUC = 0.87, p = 0.01). Higher levels of tyramine-O-sulfate in the tyrosine pathway were found in the late achievers in COPSAC (p = 0.0002) and in VDAART (p = 0.02). Furthermore, we observed that slow achievers were characterized by higher levels of fatty acids and products of fatty acids metabolism including acyl carnitines. Finally, we also observed changes in the lysine, histidine, glutamate, creatine and tryptophan pathways. Observing these metabolic changes in relation to gross-motor milestones in the first year of life, may be of importance for later cognitive function and mental health.

scholarly journals GROSS MOTOR FUNCTION CLASSIFICATION SYSTEM AND MANUAL ABILITY CLASSIFICATION IN CEREBRAL PALSY EVALUATION

2016 ◽  
Vol 65 (2) ◽  
pp. 170-173
Author(s):  
Ioana Grigore ◽  
◽  
Georgeta Diaconu ◽  
Catalin Prazaru ◽  
Alexandra Mania ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Classification System ◽  
First Year ◽  
Cerebral Disease ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Neurological Exam ◽  
Motor Problems ◽  
First Year Of Life

Cerebral palsy (CP) is a chronically cerebral disease, which is defined like a group of non-progressives motor diseases that onset in the first year of life and are the secondary lesions for a developed brain. At pediatric age CP is the most frequent cause of severe and infirmity motor problems. Aim of the study. Comparative framing in various degrees of severity for CP at child applying two classifications: Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS). Material and Methods. The study group included 129 children (43 girls and 86 boys) aged 2-18 years, diagnosed with various forms of CP. The study protocol included general clinical examination, neurological exam. Results. Of patients with CP watch, 24 (18,60%) were employed in both the grade I classification GMFCS and MACS. Also, of the 69 children who could walk independently (GMFCS I+II), 60 had good manual dexterity or very good (MACS I+II). Of the 35 patients with severe forms of PC (GMFCS V), 32 could not wield the objects being impressed into MACS V and 3 could handle only certain items being included in MACS IV. Conclusions. The gross motor function and the manual ability evolve on different levels of severity depending on type of CP. In diakinetic CP, ataxic CP and mixed forms of CP was noticed a higher correlation between the grades of the two classifications.

Maternal Mental Health during Children's First Year of Life: Association with Receipt of Section 8 Rental Assistance

2013 ◽  
Vol 23 (2) ◽  
pp. 281-297 ◽  
Author(s):  
Arvin Garg ◽  
Lori Burrell ◽  
Yorghos Tripodis ◽  
Elizabeth Goodman ◽  
Jeanne Brooks-Gunn ◽  
...  
Keyword(s):  
Mental Health ◽  
Maternal Mental Health ◽  
First Year ◽  
Section 8 ◽  
First Year Of Life

scholarly journals Parental Mental Health Mediates Links Between Socioeconomic Status and Child Development

2021 ◽  
Author(s):  
Tess A. Smith ◽  
Duncan Astle ◽  
Rogier Kievit
Keyword(s):  
Mental Health ◽  
Socioeconomic Status ◽  
Child Development ◽  
First Year ◽  
Parental Mental Health ◽  
Mediating Role ◽  
Parents And Children ◽  
Key Aspects ◽  
First Year Of Life ◽  
The Impact

The impact of socioeconomic status (SES) on early child development is well-established, but the mediating role of parental mental health is poorly understood. Data were obtained from The Avon Longitudinal Study of Parents and Children (N = 13,855, 44.8% female), including measures of early SES, key aspects of development during mid-late childhood (ages 7-8), and parental mental health during early childhood (ages 0-3). Parental mental health in the first year of life partially mediated the association between SES and child mental health (β = 0.016, p &lt; 0.0001), and cognitive ability (β = -0.011, p &lt; 0.05). These findings emphasise the complexity of SES-outcome associations, with other proximal factors within the first year of life partially mediating outcomes years later.

Fatty acids in colostrum from mothers of children at high risk of atopy in relation to clinical and laboratory signs of allergy in the first year of life

Allergy ◽  
2004 ◽  
Vol 59 (4) ◽  
pp. 394-400 ◽  
Author(s):  
P. Reichardt ◽  
D. Muller ◽  
U. Posselt ◽  
B. Vorberg ◽  
U. Diez ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Risk ◽  
First Year ◽  
First Year Of Life
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