scholarly journals An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

Metals ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 499 ◽  
Author(s):  
Lucia Haverová ◽  
Renáta Oriňaková ◽  
Andrej Oriňak ◽  
Radka Gorejová ◽  
Matej Baláž ◽  
...  
Keyword(s):  
Open Cell ◽  
Corrosion Study ◽  
Bone Replacement ◽  
Peg Coating

Evaluation of in vitro biocompatibility of open cell iron structures with PEG coating

2019 ◽  
Vol 475 ◽  
pp. 515-518 ◽  
Author(s):  
Renáta Oriňaková ◽  
Radka Gorejová ◽  
Ján Macko ◽  
Andrej Oriňak ◽  
Miriam Kupková ◽  
...  
Keyword(s):  
Open Cell ◽  
In Vitro Biocompatibility ◽  
Peg Coating

The effects of ethylene oxide sterilization on the in vitro cytotoxicity of a bone replacement material

1990 ◽  
Vol 4 (6) ◽  
pp. 757-762 ◽  
Author(s):  
C.E. Hastings ◽  
S.A. Martin ◽  
J.R. Heath ◽  
D.E. Mark ◽  
J.L. Mansfield ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
In Vitro Cytotoxicity ◽  
Bone Replacement Material ◽  
Bone Replacement ◽  
Ethylene Oxide Sterilization

3D Printed PLA/PCL/TiO2 Composite for Bone Replacement and Grafting

MRS Advances ◽  
2018 ◽  
Vol 3 (40) ◽  
pp. 2373-2378 ◽  
Author(s):  
Sandra E. Nájera ◽  
Monica Michel ◽  
Nam-Soo Kim
Keyword(s):  
Biomedical Applications ◽  
Fused Deposition Modeling ◽  
Fracture Strain ◽  
Fused Deposition ◽  
In Vitro Biocompatibility ◽  
Bone Replacement ◽  
Deposition Modeling ◽  
3D Printed ◽  
The Stability

ABSTRACTPolymer composites of Polylactic acid (PLA) and poly-ε-caprolactone (PCL), containing small amounts of titanium oxide (TiO2) were developed for biomedical applications. These composite materials were prepared, and then printed using Fused Deposition Modeling (FDM). 3D printed structures were characterized to determine their mechanical properties and biocompatibility. DSC analysis yielded useful information regarding the immiscibility of the different polymers, and it was observed that the particles of TiO2 improved the stability of the polymers. The ultimate tensile strength and the fracture strain increased by adding TiO2 as a filler, resulting in values of approximately 45 MPa and 5.5 % elongation. The printed composites show excellent in vitro biocompatibility including cell proliferation and adhesion, and are therefore promising candidates to be used in the biomedical field for bone replacement procedures, due to their properties similar to those of cancellous bone.

In Vitro Characterization of 3D Beta-Tricalcium Phosphate Scaffolds Reinforced with Phosphate Based-Bioactive Glass for Bone Replacement

2016 ◽  
Vol 720 ◽  
pp. 108-113
Author(s):  
Criseida Ruiz-Aguilar ◽  
E.A. Aguilar-Reyes ◽  
Ana Edith Higareda-Mendoza ◽  
C.A. León-Patiño
Keyword(s):  
Heat Treatment ◽  
Tissue Engineering ◽  
Cell Proliferation ◽  
Bone Tissue ◽  
Present Contribution ◽  
Beta Tricalcium Phosphate ◽  
Bone Replacement ◽  
Factor Therapy

Bone tissue engineering is an excellent alternative to reduce bone disorders and conditions, by inducing new functional bone regeneration starting from the synthesis of the biomaterials and then the combination of cell and factor therapy. In the present contribution, the scaffolds were made with a ratio of 80 wt.% of β-TCP and 20 wt. % of phosphate-based bioglass, in addition the phosphate-based bioglass was reinforced with zirconia in different amounts (0, 0.5 and 1.0 mol%) with the aim to reduce the dissolution rate, improve the osteoconduction and the osteogenesis of the bone tissue. The results obtained by μCT of the scaffolds containing zirconia showed a wide pore size distribution between 1.5 and 303 μm. AlamarBlue assays showed that the cell proliferation of MC3T3-E1 preosteoblasts scaffolds were sixfold increase in relation to the number of the initial cells. FE-SEM helped to observe the cauliflower structure of HA and DRX showed that crystalline phases formed after heat treatment were (NaCaPO4 and NaZr5PO4) owing both to the crystallization and combination of the bioglass and β-TCP .

Anwendung eines Bandscheibenersatzimplantats aus einer neuartigen porösen TiO2/Glas-Keramik – Teil 1: Einsatz in der Schafs-Halswirbelsäule und radiologische Verlaufsuntersuchungen / Application of a Stand-Alone Interbody Fusion Cage Based on a Novel Porous TiO2/glass Composite – Part 1: Implantation in the Sheep Cervical Spine and Radiological Evaluation

2004 ◽  
Vol 49 (12) ◽  
Author(s):  
M. C Korinth ◽  
T Hero ◽  
A. H Mahnken ◽  
C Ragoß ◽  
K Scherer
Keyword(s):  
Cervical Spine ◽  
Interbody Fusion ◽  
Porous Ceramic ◽  
In Vivo Models ◽  
Bone Replacement ◽  
Radiological Changes ◽  
Fusion Cage ◽  
Interbody Fusion Cage

AbstractZur Beurteilung des radiologischen, biomechanischen und histologischen Einwachsverhaltens neuer Materialien, Implantate und Cages für die zervikale interkorporelle Fusion, bieten sich Tiermodelle und hier insbesondere das Schafs-Halswirbelsäulenmodell an.In biomechanischen In-vitro-Versuchen an humanen Kadaver-Halswirbelsäulen wurden erste Erfahrungen hinsichtlich Primärstabilität eines Cage aus einer neuartigen, porösen TiOZur entsprechenden In-vivo-Beurteilung fusionierten wir 10 Schafs-Halswirbelsäulen in den Höhen C2/3 und C4/5 jeweils mit PMMA und einem Ecopore-Keramik-Cage und führten nativradiologische, sowie computertomographische Verlaufsuntersuchungen direkt post-operativ und alle 4 Wochen in den folgenden 2 bzw. 4 Monaten durch. Neben der Etablierung des Tiermodells, wurden die radiologischen Veränderungen im Verlauf und die Fusion der operierten Segmente analysiert. Darüberhinaus wurden Messungen der entsprechenden Bandscheibenfachhöhen (DSH) und Intervertebralwinkel (IVA) durchgeführt und verglichen.Nach Einbringen der Implantate in die Bandscheibenfächer nahm zunächst in beiden Gruppen die mittlere Bandscheibenfachhöhe und der Intervertebralwinkel zu (34,8%; 53,9%). In den folgenden Monaten verringerte sich die Bandscheibenfachhöhe nicht signifikant, deutlicher nach Ecopore-Fusion als nach PMMA-Interposition bis auf Werte unterhalb der Ausgangswerte. Ebenso nahm der Intervertebralwinkel im postoperativen Verlauf, deutlicher in der Ecopore-Gruppe als in der PMMA-Gruppe, ab (p < 0,05). Diese Veränderungen im Sinne einer Einsinterung der Implantate, konnte in den radiologischen Verlaufskontrollen morphologisch bestätigt werden. Die radiologisch beurteilbare Fusion, d.h. solide knöcherne Überbauung des operierten Segments, war nach Implantation eines Ecopore-Cage ausgeprägter (83%) als nach PMMA-Interposition (50%) (nicht statistisch signifikant).In diesem ersten Teil unserer In-vivo-Untersuchungen zu dem Einsatz des neuartigen Cage-Materials wurde die Anwendung im Spondylodesemodell der Schafs-Halswirbelsäule aufgezeigt. Es zeigten sich radiologische Unterschiede, in Bezug auf die ausgeprägtere Einsinterung des Ecopore-Cage und die deutlichere, nachweisbare Fusion des mit dem neuen Material operierten Segments. In dem ersten Teil dieser Studie wurden die radiologischen Veränderungen der fusionierten Segmente über mehrere Monate dargestellt und morphologisch analysiert, bevor die biomechanischen Analysen und Vergleiche in einem weiteren Teil präsentiert werden sollen. Animals are becoming more and more common as in vitro and in vivo models for the human spine. Especially the sheep cervical spine is stated to be of good comparability and usefulness in the evaluation of in vivo radiological, biomechanical and histological behaviour of new bone replacement materials, implants and cages for cervical spine interbody fusion.In preceding biomechanical in vitro examination human cervical spine specimens were tested after fusion with either a cubical stand-alone interbody fusion cage manufactured from a new porous TiOImmediately after placement of both implants in the disc spaces the mean DSH and IVA increased (34.8% and 53.9%, respectively). During the following months DSH decreased to a greater extent in the Ecopore-segments than in the PMMA-segments, even to a value below the initial value (p > 0,05). Similarly, the IVA decreased in both groups in the postoperative time lapse, but more distinct in the Ecopore-segments (p < 0,05). These changes in terms of a subsidence of the implants, were confirmed morphologically in the radiological examination in the course. The radiologically evaluated fusion, i.e. bony bridging of the operated segments, was more pronounced after implantation of an Ecopore-cage (83%), than after PMMA interposition (50%), but did not gain statistical significance.In this first in vivo examination of our new porous ceramic bone replacement material we showed its application in the spondylodesis model of the sheep cervical spine. Distinct radiological changes regarding evident subsidence and detectable fusion of the segments, operated on with the new biomaterial, were seen. We demonstrated the radiological changes of the fused segments during several months and analysed them morphologically, before the biomechanical evaluation will be presented in a subsequent publication.

scholarly journals Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

Metals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 130
Author(s):  
Mercè Giner ◽  
Ernesto Chicardi ◽  
Alzenira de Fátima Costa ◽  
Laura Santana ◽  
María Ángeles Vázquez-Gámez ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Tissue ◽  
Stress Shielding ◽  
Mechanical Resistance ◽  
Cellular Behavior ◽  
Biomechanical Behavior ◽  
Functional Behavior ◽  
Bone Replacement ◽  
Osteoblast Adhesion

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

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