scholarly journals Chitosan-Based Scaffold for Mineralized Tissues Regeneration

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 551
Author(s):  
Teerawat Sukpaita ◽  
Suwabun Chirachanchai ◽  
Atiphan Pimkhaokham ◽  
Ruchanee Salingcarnboriboon Ampornaramveth
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Basic Knowledge ◽  
Mineralized Tissue ◽  
Future Directions ◽  
Advantages And Disadvantages ◽  
Regenerative Dentistry ◽  
Mineralized Tissues ◽  
Insight Into

Conventional bone grafting procedures used to treat bone defects have several limitations. An important aspect of bone tissue engineering is developing novel bone substitute biomaterials for bone grafts to repair orthopedic defects. Considerable attention has been given to chitosan, a natural biopolymer primarily extracted from crustacean shells, which offers desirable characteristics, such as being biocompatible, biodegradable, and osteoconductive. This review presents an overview of the chitosan-based biomaterials for bone tissue engineering (BTE). It covers the basic knowledge of chitosan in terms of biomaterials, the traditional and novel strategies of the chitosan scaffold fabrication process, and their advantages and disadvantages. Furthermore, this paper integrates the relevant contributions in giving a brief insight into the recent research development of chitosan-based scaffolds and their limitations in BTE. The last part of the review discusses the next-generation smart chitosan-based scaffold and current applications in regenerative dentistry and future directions in the field of mineralized tissue regeneration.

scholarly journals The Role of Growth Factors in Bioactive Coatings

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1083
Author(s):  
Dragana Bjelić ◽  
Matjaž Finšgar
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Healing Process ◽  
Therapeutic Agents ◽  
Ageing Population ◽  
Bioactive Coatings ◽  
Bioactive Coating ◽  
Advantages And Disadvantages

With increasing obesity and an ageing population, health complications are also on the rise, such as the need to replace a joint with an artificial one. In both humans and animals, the integration of the implant is crucial, and bioactive coatings play an important role in bone tissue engineering. Since bone tissue engineering is about designing an implant that maximally mimics natural bone and is accepted by the tissue, the search for optimal materials and therapeutic agents and their concentrations is increasing. The incorporation of growth factors (GFs) in a bioactive coating represents a novel approach in bone tissue engineering, in which osteoinduction is enhanced in order to create the optimal conditions for the bone healing process, which crucially affects implant fixation. For the application of GFs in coatings and their implementation in clinical practice, factors such as the choice of one or more GFs, their concentration, the coating material, the method of incorporation, and the implant material must be considered to achieve the desired controlled release. Therefore, the avoidance of revision surgery also depends on the success of the design of the most appropriate bioactive coating. This overview considers the integration of the most common GFs that have been investigated in in vitro and in vivo studies, as well as in human clinical trials, with the aim of applying them in bioactive coatings. An overview of the main therapeutic agents that can stimulate cells to express the GFs necessary for bone tissue development is also provided. The main objective is to present the advantages and disadvantages of the GFs that have shown promise for inclusion in bioactive coatings according to the results of numerous studies.

scholarly journals Informative article. Scaffold in bone tissue engineering

2017 ◽  
Vol 64 (1) ◽  
pp. 32-40
Author(s):  
Vukoman Jokanović ◽  
Božana Čolović ◽  
Marijana Popović-Bajić ◽  
Marija Živković-Sandić
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Porous Structure ◽  
Pore Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Appropriate Technology ◽  
Biocompatible Materials ◽  
Advantages And Disadvantages ◽  
Ceramic Brackets

Summary Treatment of bone tissue injuries and diseases is still a great challenge for surgeons, but also for researchers who work with materials. Today stem cells are commonly used in bone tissue engineering. However, advances in biocompatible materials design, especially biodegradable porous structure (scaffold) is gaining an important role in the treatment of diseased bone tissue. The basic advantage of these carriers is specifically designed scaffold with defined porosity and pore structure that is favourable for cells settlement. Scaffolds are most commonly used as ceramic brackets because they have excellent characteristics in biodegradation and bioactivity. The process of scaffold production is important because the appropriate technology must ensure control of liquids and reproducibility of scaffold production through standardized process. The aim of this study was to present some of different procedures of scaffold production in bone tissue engineering and point out the advantages and disadvantages of these methods.

scholarly journals Microbial-Derived Polyhydroxyalkanoate-Based Scaffolds for Bone Tissue Engineering: Biosynthesis, Properties, and Perspectives

2021 ◽  
Vol 9 ◽  
Author(s):  
Jian Li ◽  
Xu Zhang ◽  
Anjaneyulu Udduttula ◽  
Zhi Shan Fan ◽  
Jian Hai Chen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Large Scale ◽  
Lower Cost ◽  
Culture Conditions ◽  
Manufacturing Technologies ◽  
Insight Into

Polyhydroxyalkanoates (PHAs) are a class of structurally diverse natural biopolyesters, synthesized by various microbes under unbalanced culture conditions. PHAs as biomedical materials have been fabricated in various forms to apply to tissue engineering for the past years due to their excellent biodegradability, inherent biocompatibility, modifiable mechanical properties, and thermo-processability. However, there remain some bottlenecks in terms of PHA production on a large scale, the purification process, mechanical properties, and biodegradability of PHA, which need to be further resolved. Therefore, scientists are making great efforts via synthetic biology and metabolic engineering tools to improve the properties and the product yields of PHA at a lower cost for the development of various PHA-based scaffold fabrication technologies to widen biomedical applications, especially in bone tissue engineering. This review aims to outline the biosynthesis, structures, properties, and the bone tissue engineering applications of PHA scaffolds with different manufacturing technologies. The latest advances will provide an insight into future outlooks in PHA-based scaffolds for bone tissue engineering.

An introduction to bone tissue engineering

2019 ◽  
Vol 43 (2) ◽  
pp. 69-86 ◽  
Author(s):  
Željka Perić Kačarević ◽  
Patrick Rider ◽  
Said Alkildani ◽  
Sujith Retnasingh ◽  
Marija Pejakić ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Structure ◽  
Tissue Scaffolds ◽  
Pathogen Transmission ◽  
The Body ◽  
Bioactive Molecules ◽  
Advantages And Disadvantages ◽  
Degradation Rates

Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

An insight into cell-laden 3D-printed constructs for bone tissue engineering

2020 ◽  
Vol 8 (43) ◽  
pp. 9836-9862
Author(s):  
S. Swetha ◽  
K. Lavanya ◽  
R. Sruthi ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
3D Printed ◽  
Insight Into

In this review, we have spotlighted various combinations of bioinks to optimize the biofabrication of 3D bone constructs.

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