An insight into cell-laden 3D-printed constructs for bone tissue engineering

2020 ◽  
Vol 8 (43) ◽  
pp. 9836-9862
Author(s):  
S. Swetha ◽  
K. Lavanya ◽  
R. Sruthi ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
3D Printed ◽  
Insight Into

In this review, we have spotlighted various combinations of bioinks to optimize the biofabrication of 3D bone constructs.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals Systematic characterization of 3D-printed PCL/β-TCP scaffolds for biomedical devices and bone tissue engineering: Influence of composition and porosity

2018 ◽  
Vol 33 (14) ◽  
pp. 1948-1959 ◽  
Author(s):  
Arnaud Bruyas ◽  
Frank Lou ◽  
Alexander M. Stahl ◽  
Michael Gardner ◽  
William Maloney ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Devices ◽  
3D Printed ◽  
Image Position

Abstract

3D printed porous polycaprolactone/oyster shell powder (PCL/OSP) scaffolds for bone tissue engineering

2018 ◽  
Vol 5 (4) ◽  
pp. 045403 ◽  
Author(s):  
Wenfeng Luo ◽  
Shuangying Zhang ◽  
Yuewei Lan ◽  
Chen Huang ◽  
Chao Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Oyster Shell ◽  
3D Printed ◽  
Oyster Shell Powder ◽  
Shell Powder

scholarly journals Enhancing X-ray Attenuation of 3D Printed Gelatin Methacrylate (GelMA) Hydrogels Utilizing Gold Nanoparticles for Bone Tissue Engineering Applications

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 367 ◽  
Author(s):  
Nehar Celikkin ◽  
Simone Mastrogiacomo ◽  
X. Walboomers ◽  
Wojciech Swieszkowski
Keyword(s):  
Tissue Engineering ◽  
Gold Nanoparticles ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Properties ◽  
Proof Of Concept ◽  
New Bone Formation ◽  
X Ray ◽  
3D Printed ◽  
Low Toxicity

Bone tissue engineering is a rapidly growing field which is currently progressing toward clinical applications. Effective imaging methods for longitudinal studies are critical to evaluating the new bone formation and the fate of the scaffolds. Computed tomography (CT) is a prevailing technique employed to investigate hard tissue scaffolds; however, the CT signal becomes weak in mainly-water containing materials, which hinders the use of CT for hydrogels-based materials. Nevertheless, hydrogels such as gelatin methacrylate (GelMA) are widely used for tissue regeneration due to their optimal biological properties and their ability to induce extracellular matrix formation. To date, gold nanoparticles (AuNPs) have been suggested as promising contrast agents, due to their high X-ray attenuation, biocompatibility, and low toxicity. In this study, the effects of different sizes and concentrations of AuNPs on the mechanical properties and the cytocompatibility of the bulk GelMA-AuNPs scaffolds were evaluated. Furthermore, the enhancement of CT contrast with the cytocompatible size and concentration of AuNPs were investigated. 3D printed GelMA and GelMA-AuNPs scaffolds were obtained and assessed for the osteogenic differentiation of mesenchymal stem cells (MSC). Lastly, 3D printed GelMA and GelMA-AuNPs scaffolds were scanned in a bone defect utilizing µCT as the proof of concept that the GelMA-AuNPs are good candidates for bone tissue engineering with enhanced visibility for µCT imaging.

Recent progress in 3D-printed polymeric scaffolds for bone tissue engineering

2020 ◽  
pp. 59-81 ◽  
Author(s):  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Pariksha J. Kondiah ◽  
Thashree Marimuthu ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recent Progress ◽  
Polymeric Scaffolds ◽  
3D Printed

scholarly journals Study on antibacterial properties and cytocompatibility of EPL coated 3D printed PCL/HA composite scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4805-4816 ◽  
Author(s):  
Lijiao Tian ◽  
Zhenting Zhang ◽  
Bin Tian ◽  
Xin Zhang ◽  
Na Wang
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Critical Role ◽  
Antibacterial Properties ◽  
Composite Scaffolds ◽  
Biomaterial Scaffolds ◽  
3D Printed

Biomaterial scaffolds play a critical role in bone tissue engineering.

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